Strain Name:
C57BL/6J-MtgxR2210Btlr/Mmmh
Stock Number:
040212-MU
Citation ID:
RRID:MMRRC_040212-MU
Other Names:
R2210 (G1), C57BL/6J-MtgxR2210Btlr
Major Collection:

Strain Information

Dct
Name: dopachrome tautomerase
Synonyms: tyrosinase-related protein-2, TRP-2, Tyrp-2, Tyrp2, TRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13190
VEGA: 14
HGNC: HGNC:2709
Homologene: 1447
Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: RPC5, Sin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26939
Homologene: 14052
Cops4
Name: COP9 signalosome subunit 4
Synonyms: COP9 complex S4, D5Ertd774e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26891
Homologene: 8067
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: Sumo-1 activating enzyme subunit 2, UBA2, anthracycline-associated resistance, Arx, SAE2, Uble1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 50995
Homologene: 4018
Cbln3
Name: cerebellin 3 precursor protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56410
VEGA: 14
Homologene: 56861
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Prr12
Name: proline rich 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233210
Homologene: 18957
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: 2900041G10Rik, KPI-2, cprk, KPI2, A330101P12Rik, BREK, AATYK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231876
Homologene: 8948
Cct7
Name: chaperonin containing Tcp1, subunit 7 (eta)
Synonyms: Cctz, Ccth
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12468
HGNC: HGNC:1622
Homologene: 4694
Mc4r
Name: melanocortin 4 receptor
Synonyms: Fatboy, Pkcp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17202
VEGA: 18
HGNC: HGNC:6932
Homologene: 4320
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, 8030453L17Rik, E430018P19Rik, KMT2H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 192195
Homologene: 10225
Sumf1
Name: sulfatase modifying factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58911
Homologene: 16268
Icam1
Name: intercellular adhesion molecule 1
Synonyms: CD54, MALA-2, Icam-1, Ly-47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15894
VEGA: 9
HGNC: HGNC:5344
Homologene: 168
Casr
Name: calcium-sensing receptor
Synonyms: CaR, Gprc2a, cation sensing receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
2210016L21Rik
Name: RIKEN cDNA 2210016L21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72357
Homologene: 11285
Ube2d3
Name: ubiquitin-conjugating enzyme E2D 3
Synonyms: 9430029A22Rik, 1100001F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66105
Homologene: 123914
Triml2
Name: tripartite motif family-like 2
Synonyms: EG622117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 622117
Homologene: 18316
Cables1
Name: CDK5 and Abl enzyme substrate 1
Synonyms: interactor-1 with cdk3, ik3-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 63955
VEGA: 18
Homologene: 11097
Emc10
Name: ER membrane protein complex subunit 10
Synonyms: 5430410O10Rik, 2310044H10Rik, Mirta22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69683
Homologene: 18036
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: 1810007M14Rik, Pax3/7bp, Gcfc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67367
Homologene: 9604
Tmem107
Name: transmembrane protein 107
Synonyms: 2810049P21Rik, 1110004B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66910
Homologene: 12052
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: dunce, Dpde4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: DRES9, RdgB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Itgb2l
Name: integrin beta 2-like
Synonyms: pactolus, 5033406G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16415
HGNC: HGNC:6155
Gm4884
Name: predicted gene 4884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233164
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Fish, Sh3md1, Tks5, 2310014D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Unc5d
Name: unc-5 netrin receptor D
Synonyms: Unc5h4, D930029E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 210801
Homologene: 15450
Or8g30
Name: olfactory receptor family 8 subfamily G member 30
Synonyms: GA_x6K02T2PVTD-33016899-33015934, MOR171-45, MOR171-51, Olfr948
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257912
VEGA: 9
HGNC: HGNC:8484
Homologene: 79377
Pnliprp2
Name: pancreatic lipase-related protein 2
Synonyms: PLRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18947
VEGA: 19
HGNC: HGNC:9157
Homologene: 3936
Dgkq
Name: diacylglycerol kinase, theta
Synonyms: 110kDa, Dagk4, DAGK7, Dgkd, Dgk theta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 110524
HGNC: HGNC:2856
Homologene: 20352
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Stac
Name: src homology three (SH3) and cysteine rich domain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20840
Homologene: 2371
AC135640.2
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Majin
Name: membrane anchored junction protein
Synonyms: 1700123I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 622554
Homologene: 78163
Cd1d2
Name: CD1d2 antigen
Synonyms: CD1.2, Cd1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12480
HGNC: HGNC:1637
Pus7l
Name: pseudouridylate synthase 7-like
Synonyms: 3000003F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78895
Homologene: 12842
Mettl7b
Name: methyltransferase like 7B
Synonyms: 0610006F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71664
VEGA: 10
Homologene: 12400
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 118,717,503 bp
  • G to T, chromosome 3 at 86,987,734 bp
  • G to T, chromosome 3 at 89,066,298 bp
  • T to A, chromosome 3 at 135,463,041 bp
  • A to T, chromosome 4 at 102,597,475 bp
  • T to A, chromosome 4 at 143,994,219 bp
  • T to C, chromosome 5 at 100,543,831 bp
  • C to A, chromosome 5 at 108,660,523 bp
  • C to G, chromosome 5 at 114,942,289 bp
  • A to G, chromosome 5 at 144,147,609 bp
  • G to A, chromosome 6 at 85,459,230 bp
  • A to T, chromosome 6 at 108,144,711 bp
  • T to C, chromosome 7 at 34,163,162 bp
  • A to T, chromosome 7 at 41,043,546 bp
  • G to A, chromosome 7 at 44,493,192 bp
  • A to G, chromosome 7 at 45,049,351 bp
  • G to T, chromosome 7 at 106,330,205 bp
  • T to A, chromosome 7 at 120,944,533 bp
  • A to G, chromosome 8 at 28,761,797 bp
  • T to C, chromosome 8 at 43,183,360 bp
  • A to G, chromosome 9 at 21,019,033 bp
  • A to T, chromosome 9 at 39,318,793 bp
  • G to A, chromosome 9 at 95,907,300 bp
  • G to A, chromosome 9 at 111,602,570 bp
  • A to G, chromosome 10 at 12,688,278 bp
  • T to A, chromosome 10 at 128,958,722 bp
  • A to T, chromosome 11 at 59,068,087 bp
  • A to G, chromosome 11 at 69,071,270 bp
  • A to T, chromosome 12 at 51,806,462 bp
  • T to A, chromosome 14 at 55,883,926 bp
  • T to C, chromosome 14 at 118,043,149 bp
  • C to T, chromosome 15 at 74,547,704 bp
  • T to G, chromosome 15 at 94,540,292 bp
  • AG to AGG, chromosome 16 at 32,755,176 bp
  • A to G, chromosome 16 at 36,509,588 bp
  • T to C, chromosome 16 at 91,044,002 bp
  • C to T, chromosome 16 at 96,426,221 bp
  • T to C, chromosome 18 at 11,924,801 bp
  • A to T, chromosome 18 at 66,859,395 bp
  • T to C, chromosome 19 at 4,105,253 bp
  • C to A, chromosome 19 at 6,222,698 bp
  • A to G, chromosome 19 at 47,267,343 bp
  • T to G, chromosome 19 at 58,777,407 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2210 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040212-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.