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Strain Name:
C57BL/6J-MtgxR2212Btlr/Mmmh
Stock Number:
040214-MU
Citation ID:
RRID:MMRRC_040214-MU
Other Names:
R2212 (G1), C57BL/6J-MtgxR2212Btlr
Major Collection:

Strain Information

Ubn2
Name: ubinuclein 2
Synonyms: 6030408G03Rik, 2900060J04Rik, D130059P03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320538
Homologene: 45564
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Il4i1
Name: interleukin 4 induced 1
Synonyms: Fig1-ps, Fig1, H46, H4, H-46, H-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14204
Homologene: 22567
Trim59
Name: tripartite motif-containing 59
Synonyms: 2700022F13Rik, TSBF1, Mrf1, 2310035M22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66949
Homologene: 32644
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 2010005I16Rik, 1110013E22Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Mdm4
Name: transformed mouse 3T3 cell double minute 4
Synonyms: Mdmx, 4933417N07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17248
HGNC: HGNC:6974
Homologene: 1794
Ap2a2
Name: adaptor-related protein complex 2, alpha 2 subunit
Synonyms: alpha-C adaptin, alpha-adaptin C, L25, Adtab, 2410074K14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11772
HGNC: HGNC:562
Homologene: 5335
Tex9
Name: testis expressed gene 9
Synonyms: tsec-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21778
Homologene: 32072
Nsmaf
Name: neutral sphingomyelinase (N-SMase) activation associated factor
Synonyms: Fan, factor associated with N-SMase activation
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18201
HGNC: HGNC:8017
Homologene: 2652
Ehmt2
Name: euchromatic histone lysine N-methyltransferase 2
Synonyms: NG36, G9a, D17Ertd710e, Bat8, KMT1C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110147
Homologene: 48460
Angptl4
Name: angiopoietin-like 4
Synonyms: FIAF, BK89, HFARP, NG27
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57875
Homologene: 10755
Vrk3
Name: vaccinia related kinase 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101568
Homologene: 9509
Spryd3
Name: SPRY domain containing 3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223918
Homologene: 13138
Lemd1
Name: LEM domain containing 1
Synonyms: LEMP-1, 4930540I23Rik, 6430514M23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213409
Sez6l
Name: seizure related 6 homolog like
Synonyms: Acig1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56747
Homologene: 10895
Lcp2
Name: lymphocyte cytosolic protein 2
Synonyms: SLP-76, twm, SLP76, m1Khoe
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16822
HGNC: HGNC:6529
Homologene: 4065
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231125
Homologene: 15119
Rusc2
Name: RUN and SH3 domain containing 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100213
Homologene: 18967
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Gckr
Name: glucokinase regulatory protein
Synonyms: GKRP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231103
HGNC: HGNC:4196
Homologene: 1139
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246177
Homologene: 27996
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114875
Homologene: 23815
Trim69
Name: tripartite motif-containing 69
Synonyms: 4921519C19Rik, Trif, Rnf36
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70928
Homologene: 18827
Prss43
Name: serine protease 43
Synonyms: LOC272643, Tessp3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 272643
Homologene: 138484
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208795
Homologene: 101673
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: PGC-1beta/ERRL1, 4631412G21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170826
Homologene: 15776
Deup1
Name: deuterosome assembly protein 1
Synonyms: 4933401K09Rik, Ccdc67
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234964
Homologene: 18760
Serpina3j
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J
Synonyms: alpha-1 antiproteinase, Gm4931
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238395
HGNC: HGNC:16
Homologene: 120222
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224582
Homologene: 129678
Taok2
Name: TAO kinase 2
Synonyms: TAO1, PSK1, 1110033K02Rik, MAP3K17, TAO2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381921
Homologene: 74531
Golgb1
Name: golgin B1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: PFK-2/FBPase-2 gene B, 4930568D07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Ppp1r3b
Name: protein phosphatase 1, regulatory subunit 3B
Synonyms: GL
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244416
Homologene: 11615
Krt84
Name: keratin 84
Synonyms: HRb-1, Krt2-3, Krt2-16
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16680
VEGA: 15
HGNC: HGNC:6461
Homologene: 22473
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: ST6GalNAc I, Siat7a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20445
Homologene: 7937
Mep1a
Name: meprin 1 alpha
Synonyms: meprin A alpha-subunit, Mep-1a, Mep-1, meprin alpha, Mep1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17287
HGNC: HGNC:7015
Homologene: 31323
Tusc1
Name: tumor suppressor candidate 1
Synonyms: 2200001D17Rik, TSG-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69136
Homologene: 84597
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Or51f5
Name: olfactory receptor family 51 subfamily F member 5
Synonyms: GA_x6K02T2PBJ9-5491151-5492095, MOR14-2, Olfr561
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259096
Homologene: 133029
Or51q1
Name: olfactory receptor family 51 subfamily Q member 1
Synonyms: GA_x6K02T2PBJ9-6713641-6714588, MOR5-2, Olfr635
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259122
Homologene: 133592
Fscn2
Name: fascin actin-bundling protein 2
Synonyms: C630046B20Rik, ahl8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 238021
HGNC: HGNC:3960
Homologene: 22722
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219140
Homologene: 19482
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 21674
Adarb2
Name: adenosine deaminase, RNA-specific, B2
Synonyms: RED2, Adar3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94191
HGNC: HGNC:227
Homologene: 10276
Or2v2
Name: olfactory receptor family 2 subfamily V member 2
Synonyms: GA_x6K02T2QP88-6321048-6321995, MOR276-2, Olfr1396
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258334
Homologene: 28537
Fcna
Name: ficolin A
Synonyms: ficolin A, Fcn1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14133
Homologene: 117949
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Kcnq3
Name: potassium voltage-gated channel, subfamily Q, member 3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110862
HGNC: HGNC:6297
Homologene: 20949
Rusf1
Name: RUS family member 1
Synonyms: BC017158
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233913
Homologene: 11232
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il1rrp, Il18ralpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Cibar1
Name: CBY1 interacting BAR domain containing 1
Synonyms: 6720467C03Rik, Fam92a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68099
Homologene: 12234
Pla2g4f
Name: phospholipase A2, group IVF
Synonyms: 4732472I07Rik, Pla2zeta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271844
Homologene: 77933
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209462
Homologene: 10807
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: EAAT5, A930031E15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242607
Homologene: 21327
Ubash3a
Name: ubiquitin associated and SH3 domain containing, A
Synonyms: 5830413C03Rik, Sts-2, TULA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328795
Homologene: 56833
Syt1
Name: synaptotagmin I
Synonyms: G630098F17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20979
Homologene: 4122
2700062C07Rik
Name: RIKEN cDNA 2700062C07 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68046
VEGA: 18
Homologene: 12230
Or10d4
Name: olfactory receptor family 10 subfamily D member 4
Synonyms: GA_x6K02T2PVTD-33365879-33366814, MOR224-7P, MOR224-13, Olfr963
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258087
VEGA: 9
Homologene: 105216
Spag8
Name: sperm associated antigen 8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433700
Homologene: 8250
Phlda1
Name: pleckstrin homology like domain, family A, member 1
Synonyms: TDAG51, DT1P1B11, Tdag
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21664
HGNC: HGNC:8933
Homologene: 7203
Coq10a
Name: coenzyme Q10A
Synonyms: LOC210582
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210582
VEGA: 10
Homologene: 27027
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 14,274,209 bp
  • A to T, chromosome 1 at 40,491,067 bp
  • A to T, chromosome 1 at 130,707,532 bp
  • C to A, chromosome 1 at 132,228,286 bp
  • T to C, chromosome 1 at 132,994,522 bp
  • A to G, chromosome 1 at 140,530,800 bp
  • G to A, chromosome 1 at 180,963,114 bp
  • G to C, chromosome 2 at 25,627,493 bp
  • T to C, chromosome 2 at 120,303,106 bp
  • T to C, chromosome 2 at 122,178,644 bp
  • C to A, chromosome 2 at 126,375,757 bp
  • A to T, chromosome 2 at 165,815,451 bp
  • T to C, chromosome 3 at 69,037,543 bp
  • C to A, chromosome 4 at 6,396,732 bp
  • A to G, chromosome 4 at 12,171,696 bp
  • T to G, chromosome 4 at 43,415,935 bp
  • T to A, chromosome 4 at 43,651,606 bp
  • C to A, chromosome 4 at 93,334,936 bp
  • A to G, chromosome 4 at 108,010,994 bp
  • T to A, chromosome 5 at 31,300,867 bp
  • C to T, chromosome 5 at 34,199,684 bp
  • T to G, chromosome 5 at 92,228,722 bp
  • A to G, chromosome 5 at 112,475,361 bp
  • A to G, chromosome 6 at 38,498,739 bp
  • C to T, chromosome 6 at 140,002,081 bp
  • C to T, chromosome 7 at 44,775,442 bp
  • T to C, chromosome 7 at 44,836,658 bp
  • T to C, chromosome 7 at 102,774,755 bp
  • T to C, chromosome 7 at 103,979,402 bp
  • T to C, chromosome 7 at 126,870,858 bp
  • T to C, chromosome 7 at 128,276,427 bp
  • T to A, chromosome 7 at 141,598,776 bp
  • A to G, chromosome 8 at 35,384,225 bp
  • A to G, chromosome 8 at 104,547,679 bp
  • A to T, chromosome 9 at 15,599,843 bp
  • T to A, chromosome 9 at 39,669,228 bp
  • C to A, chromosome 9 at 72,477,758 bp
  • G to C, chromosome 9 at 110,829,464 bp
  • T to A, chromosome 10 at 45,648,675 bp
  • G to T, chromosome 10 at 108,504,414 bp
  • A to T, chromosome 10 at 111,507,168 bp
  • A to G, chromosome 10 at 128,365,129 bp
  • G to T, chromosome 11 at 6,517,870 bp
  • A to C, chromosome 11 at 34,070,995 bp
  • C to T, chromosome 11 at 49,113,216 bp
  • A to G, chromosome 11 at 116,765,856 bp
  • G to T, chromosome 11 at 120,361,591 bp
  • G to A, chromosome 12 at 104,314,726 bp
  • T to C, chromosome 13 at 8,752,618 bp
  • AAGGAG to AAG, chromosome 14 at 7,881,652 bp
  • T to A, chromosome 14 at 32,661,602 bp
  • A to G, chromosome 14 at 60,706,723 bp
  • A to T, chromosome 15 at 66,020,293 bp
  • A to C, chromosome 15 at 101,532,538 bp
  • A to G, chromosome 15 at 102,130,276 bp
  • A to G, chromosome 16 at 36,887,347 bp
  • A to G, chromosome 16 at 49,138,732 bp
  • A to T, chromosome 17 at 20,573,947 bp
  • A to T, chromosome 17 at 31,218,034 bp
  • A to T, chromosome 17 at 32,487,063 bp
  • A to G, chromosome 17 at 33,775,418 bp
  • A to G, chromosome 17 at 34,899,365 bp
  • G to A, chromosome 17 at 36,548,930 bp
  • G to A, chromosome 17 at 43,477,263 bp
  • A to G, chromosome 18 at 24,470,920 bp
  • G to A, chromosome 18 at 61,311,220 bp
  • T to A, chromosome Y at 2,663,339 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2212 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040214-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.