Strain Name:
C57BL/6J-MtgxR2234Btlr/Mmmh
Stock Number:
040235-MU
Citation ID:
RRID:MMRRC_040235-MU
Other Names:
R2234 (G1), C57BL/6J-MtgxR2234Btlr
Major Collection:

Gene Information

Capzb
Name: capping protein (actin filament) muscle Z-line, beta
Synonyms: CPbeta2, CPB2, CPbeta1, CPB1, 1700120C01Rik, Cappb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12345
HGNC: HGNC:1491
Homologene: 3620
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 170750
Homologene: 6424
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Smg7
Name: Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms: 9430023P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226517
Homologene: 32235
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: E230024D05Rik, 9030416H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71521
Homologene: 22877
Sf3a2
Name: splicing factor 3a, subunit 2
Synonyms: SFA66, PRP11, Sap62, 66kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20222
Homologene: 133823
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72656
Homologene: 9888
Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Synonyms: 1200015F06Rik, Mypt1, D10Ertd625e, 5730577I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17931
VEGA: 10
HGNC: HGNC:7618
Homologene: 1855
Rnf216
Name: ring finger protein 216
Synonyms: UIP83, F830018F18Rik, 2810055G22Rik, Ubce7ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108086
Homologene: 19442
Crh
Name: corticotropin releasing hormone
Synonyms: CRF, corticotropin releasing factor, LOC383938, corticotropin-releasing factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12918
HGNC: HGNC:2355
Homologene: 599
Akap8l
Name: A kinase (PRKA) anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Dhx16
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 16
Synonyms: 2410006N22Rik, DBP2, Ddx16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Acbd6
Name: acyl-Coenzyme A binding domain containing 6
Synonyms: 0610010G04Rik, 2610100E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72482
Homologene: 12465
Cemip
Name: cell migration inducing protein, hyaluronan binding
Synonyms: 12H19.01.T7, 6330404C01Rik, 9930013L23Rik, Hybid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80982
Homologene: 10268
Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
Synonyms: 3110079H08Rik, Dncic2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13427
HGNC: HGNC:2964
Homologene: 37921
Cd81
Name: CD81 antigen
Synonyms: Tspan28, Tapa1, Tapa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12520
HGNC: HGNC:1701
Homologene: 20915
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: 1810007M14Rik, Pax3/7bp, Gcfc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67367
Homologene: 9604
Dazap1
Name: DAZ associated protein 1
Synonyms: 2410042M16Rik, mPrrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70248
HGNC: HGNC:2683
Homologene: 134440
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Adarb1
Name: adenosine deaminase, RNA-specific, B1
Synonyms: RED1, ADAR2, D10Bwg0447e, 1700057H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110532
HGNC: HGNC:226
Homologene: 8280
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: D330020E01Rik, pcy, nephrocystin 3, 3632410F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Nfkbid
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
Synonyms: IkappaBNS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243910
Homologene: 13101
Xylt2
Name: xylosyltransferase II
Synonyms: E030002B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217119
Homologene: 23349
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Gm12695
Name: predicted gene 12695
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 620779
Homologene: 51847
Scap
Name: SREBF chaperone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235623
Homologene: 8160
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Olfr1346
Name: olfactory receptor 1346
Synonyms: GA_x6K02T2QGBW-3203957-3204898, MOR103-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258918
Homologene: 74134
Rabepk
Name: Rab9 effector protein with kelch motifs
Synonyms: 8430412M01Rik, 9530020D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227746
Homologene: 48772
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Ssc5d
Name: scavenger receptor cysteine rich family, 5 domains
Synonyms: s5d-srcrb, A430110N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269855
Homologene: 77555
Trim65
Name: tripartite motif-containing 65
Synonyms: 4732463G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 338364
Homologene: 27844
Cpb1
Name: carboxypeptidase B1 (tissue)
Synonyms: 2210008M23Rik, 0910001A18Rik, 1810063F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Hid1
Name: HID1 domain containing
Synonyms: C630004H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217310
Homologene: 12737
Tbx18
Name: T-box18
Synonyms: 2810012F10Rik, 2810404D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76365
Homologene: 11384
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 435845
Homologene: 78847
Myot
Name: myotilin
Synonyms: 5530402I04Rik, Ttid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 58916
Homologene: 4942
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: D530004J12Rik, Ccdc129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232016
Homologene: 52344
Tnk1
Name: tyrosine kinase, non-receptor, 1
Synonyms: Kos1, Tnk1b, Tnk1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83813
Homologene: 2966
Iglon5
Name: IgLON family member 5
Synonyms: A230106M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210094
Homologene: 46295
Scgb1b27
Name: secretoglobin, family 1B, member 27
Synonyms: Abp, Sal-1, Tcp, Abpa, Abpa27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11354
Homologene: 114479
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Gm7196, Vmn2r-ps113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 637021
Homologene: 115024
Chrnb1
Name: cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
Synonyms: Achr-2, Acrb, AChR beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11443
HGNC: HGNC:1961
Homologene: 594
Olfr1219
Name: olfactory receptor 1219
Synonyms: GA_x6K02T2Q125-50555603-50554668, MOR233-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258901
Homologene: 27292
Stambp
Name: STAM binding protein
Synonyms: 5330424L14Rik, 5730422L11Rik, Amsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70527
Homologene: 4719
Clca1
Name: chloride channel accessory 1
Synonyms: gob-5, gob5, Clca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Hspa2
Name: heat shock protein 2
Synonyms: 70kDa, Hsp70-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15512
VEGA: 12
HGNC: HGNC:5235
Homologene: 68564
Olfr832
Name: olfactory receptor 832
Synonyms: GA_x6K02T2PVTD-12687800-12688738, MOR153-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258075
HGNC: HGNC:8467
Homologene: 128143
Lrrc56
Name: leucine rich repeat containing 56
Synonyms: 5730427C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70552
Homologene: 115748
Chfr
Name: checkpoint with forkhead and ring finger domains
Synonyms: RNF116, 5730484M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231600
Homologene: 10078
Uck1
Name: uridine-cytidine kinase 1
Synonyms: URK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22245
Homologene: 7990
Ac165356.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Thap4
Name: THAP domain containing 4
Synonyms: 2010320B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67026
Homologene: 12075
Pax8
Name: paired box 8
Synonyms: Pax-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18510
HGNC: HGNC:8622
Homologene: 2589
Olfr1089
Name: olfactory receptor 1089
Synonyms: GA_x6K02T2Q125-48226321-48225386, MOR193-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257933
Homologene: 79354
BC035947
Name: cDNA sequence BC035947
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Olfr710
Name: olfactory receptor 710
Synonyms: GA_x6K02T2PBJ9-9325348-9324416, MOR260-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258594
Homologene: 27218
Csta1
Name: cystatin A1
Synonyms: Csta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209294
HGNC: HGNC:2481
Homologene: 3819
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 78,497,962 bp
  • G to T, chromosome 1 at 93,725,212 bp
  • A to T, chromosome 1 at 152,868,313 bp
  • A to G, chromosome 1 at 155,558,708 bp
  • A to G, chromosome 2 at 24,443,102 bp
  • T to C, chromosome 2 at 32,258,303 bp
  • A to T, chromosome 2 at 34,795,234 bp
  • C to T, chromosome 2 at 71,249,420 bp
  • A to G, chromosome 2 at 86,733,577 bp
  • A to G, chromosome 2 at 89,074,248 bp
  • A to T, chromosome 3 at 19,693,932 bp
  • A to T, chromosome 3 at 20,275,465 bp
  • G to T, chromosome 3 at 145,009,068 bp
  • G to A, chromosome 4 at 11,221,305 bp
  • C to T, chromosome 4 at 96,724,029 bp
  • T to A, chromosome 4 at 139,262,023 bp
  • A to T, chromosome 5 at 65,654,098 bp
  • G to T, chromosome 5 at 86,282,086 bp
  • A to G, chromosome 5 at 110,170,863 bp
  • G to A, chromosome 5 at 143,090,926 bp
  • A to T, chromosome 6 at 55,897,812 bp
  • A to G, chromosome 6 at 83,551,978 bp
  • A to G, chromosome 7 at 4,943,850 bp
  • T to C, chromosome 7 at 6,474,442 bp
  • T to A, chromosome 7 at 30,425,859 bp
  • T to C, chromosome 7 at 34,021,824 bp
  • T to C, chromosome 7 at 43,480,638 bp
  • T to A, chromosome 7 at 68,212,080 bp
  • G to T, chromosome 7 at 83,998,562 bp
  • A to C, chromosome 7 at 106,081,381 bp
  • C to A, chromosome 7 at 106,944,620 bp
  • T to A, chromosome 7 at 141,198,294 bp
  • T to A, chromosome 7 at 143,066,319 bp
  • T to C, chromosome 8 at 48,276,169 bp
  • G to A, chromosome 9 at 15,998,271 bp
  • A to T, chromosome 9 at 18,944,816 bp
  • G to T, chromosome 9 at 87,724,350 bp
  • G to A, chromosome 9 at 104,037,376 bp
  • T to C, chromosome 9 at 110,381,593 bp
  • A to G, chromosome 10 at 77,317,349 bp
  • A to G, chromosome 10 at 80,277,599 bp
  • G to T, chromosome 10 at 80,802,829 bp
  • A to G, chromosome 10 at 108,198,919 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • A to T, chromosome 11 at 69,795,602 bp
  • C to T, chromosome 11 at 69,855,191 bp
  • C to T, chromosome 11 at 94,669,996 bp
  • A to G, chromosome 11 at 115,351,119 bp
  • G to T, chromosome 11 at 116,130,677 bp
  • A to G, chromosome 12 at 76,404,645 bp
  • A to C, chromosome 12 at 98,841,581 bp
  • A to T, chromosome 15 at 76,176,947 bp
  • T to C, chromosome 15 at 98,865,248 bp
  • C to A, chromosome 16 at 34,176,262 bp
  • C to T, chromosome 16 at 36,125,075 bp
  • T to C, chromosome 16 at 91,034,934 bp
  • A to T, chromosome 17 at 18,049,665 bp
  • C to T, chromosome 17 at 32,338,803 bp
  • T to C, chromosome 17 at 35,887,886 bp
  • A to G, chromosome 18 at 44,354,272 bp
  • T to G, chromosome 19 at 53,013,461 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2234 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040235-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.