Strain Name:
C57BL/6J-MtgxR2263Btlr/Mmmh
Stock Number:
040263-MU
Citation ID:
RRID:MMRRC_040263-MU
Other Names:
R2263 (G1), C57BL/6J-MtgxR2263Btlr
Major Collection:

Gene Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, SpbIV, neuroaxonal dystrophy, 5830426A08Rik, ROSA62, nmf261, 1700022P15Rik, Spnb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80297
Homologene: 11879
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Fbxl3
Name: F-box and leucine-rich repeat protein 3
Synonyms: Fbl3a, Fbxl3a, Ovtm, Play68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50789
Homologene: 8127
Armh3
Name: armadillo-like helical domain containing 3
Synonyms: 9130011E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71617
VEGA: 19
Homologene: 15843
Zc3h14
Name: zinc finger CCCH type containing 14
Synonyms: 1700016A15Rik, 1010001P15Rik, 2700069A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75553
VEGA: 12
Homologene: 32605
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103573
Homologene: 2554
Slx4ip
Name: SLX4 interacting protein
Synonyms: 2410004I22Rik, 2210009G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74243
Homologene: 49913
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Elp1
Name: elongator complex protein 1
Synonyms: 3110040G09Rik, C78473, IKAP, Ikbkap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB150, TFIIIB90, TAF3B1, TFC5, Tfnr, G630013P12Rik, B130055N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544971
Homologene: 34582
Strn3
Name: striatin, calmodulin binding protein 3
Synonyms: SG2NA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94186
VEGA: 12
Homologene: 82078
Xpo5
Name: exportin 5
Synonyms: 2410004H11Rik, 2700038C24Rik, Exp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72322
VEGA: 17
Homologene: 69316
Utp15
Name: UTP15 small subunit processome component
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105372
VEGA: 13
Homologene: 6629
Car12
Name: carbonic anhydrase 12
Synonyms: 2310047E01Rik, CA XII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76459
HGNC: HGNC:1371
Homologene: 20327
Ticam1
Name: toll-like receptor adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106759
Homologene: 8605
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Prim1
Name: DNA primase, p49 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19075
HGNC: HGNC:9369
Homologene: 730
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Zfp410
Name: zinc finger protein 410
Synonyms: D12Ertd748e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 52708
VEGA: 12
Homologene: 10918
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Uqcrfs1
Name: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Synonyms: 4430402G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66694
Homologene: 4378
Ehbp1
Name: EH domain binding protein 1
Synonyms: KIAA0903-like, Flj21950
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216565
Homologene: 22880
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: CD135, Flk-2, Flt-3, Flk2, wmfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: capsaicin receptor, VR-1, OTRPC1, Vr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193034
Homologene: 12920
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
4932431P20Rik
Name: RIKEN cDNA 4932431P20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b1203Clo, b2b1279Clo, b2b598Clo, b2b1289Clo, b2b1727Clo, Dnahc11, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Arsi
Name: arylsulfatase i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 545260
Homologene: 44428
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: LOC380917, 5031414D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 435975
Homologene: 104832
Col4a1
Name: collagen, type IV, alpha 1
Synonyms: Col4a-1, Del(8)Bru44H, Del(8)44H, Bru, Svc, Raw, alpha1(IV) collagen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12826
HGNC: HGNC:2202
Homologene: 20437
Folh1
Name: folate hydrolase 1
Synonyms: mopsm, prostate-specific membrane antigen, glutamate carboxypeptidase II, GCP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53320
HGNC: HGNC:3788
Homologene: 55826
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225207
VEGA: 18
Homologene: 9151
Shpk
Name: sedoheptulokinase
Synonyms: 4930431K22Rik, Carkl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74637
HGNC: HGNC:1492
Homologene: 8319
Dok4
Name: docking protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 114255
Homologene: 10009
Shisa9
Name: shisa family member 9
Synonyms: 2700045P11Rik, CKAMP44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72555
Homologene: 109462
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277360
Homologene: 10821
Hdac7
Name: histone deacetylase 7
Synonyms: 5830434K02Rik, Hdac7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56233
Homologene: 9124
Nmur2
Name: neuromedin U receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216749
Homologene: 49618
Eif2b4
Name: eukaryotic translation initiation factor 2B, subunit 4 delta
Synonyms: Eif2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13667
HGNC: HGNC:3260
Homologene: 5976
Cryl1
Name: crystallin, lambda 1
Synonyms: 1110025H08Rik, A230106J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68631
VEGA: 14
Homologene: 9322
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16552
Homologene: 7796
Pramel31
Name: PRAME like 31
Synonyms: Gm13119
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433779
Homologene: 83161
Fgf12
Name: fibroblast growth factor 12
Synonyms: Fhf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14167
VEGA: 16
HGNC: HGNC:3668
Homologene: 10874
Olfr1378
Name: olfactory receptor 1378
Synonyms: GA_x6K02T2QP88-4469162-4468215, MOR129-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258912
Homologene: 133679
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Olfr20
Name: olfactory receptor 20
Synonyms: MTPCR55, MTPCR06, Olfr21, GA_x6K02T2P1NL-3514066-3515010, MOR135-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258925
Homologene: 128054
Olfr574
Name: olfactory receptor 574
Synonyms: GA_x6K02T2PBJ9-5659738-5660748, MOR14-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258357
Homologene: 27137
Tekt4
Name: tektin 4
Synonyms: 1700010L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71840
Homologene: 25745
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244178
Homologene: 9700
CAAA01083517.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gpr65
Name: G-protein coupled receptor 65
Synonyms: TDAG8, Dig1, Gpcr25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14744
VEGA: 12
HGNC: HGNC:4517
Homologene: 2675
Efcab15
Name: EF-hand calcium binding domain 15
Synonyms: 1700023F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69441
Homologene: 132455
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 133,726,533 bp
  • A to G, chromosome 1 at 183,334,793 bp
  • T to C, chromosome 2 at 137,044,015 bp
  • A to T, chromosome 2 at 166,589,068 bp
  • T to C, chromosome 3 at 38,888,989 bp
  • A to G, chromosome 4 at 56,755,298 bp
  • A to G, chromosome 4 at 63,169,521 bp
  • A to G, chromosome 4 at 144,363,541 bp
  • T to C, chromosome 5 at 31,192,574 bp
  • G to A, chromosome 5 at 147,348,063 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • T to A, chromosome 7 at 27,434,357 bp
  • T to C, chromosome 7 at 29,532,562 bp
  • G to T, chromosome 7 at 42,928,607 bp
  • C to T, chromosome 7 at 50,560,821 bp
  • C to T, chromosome 7 at 86,719,765 bp
  • T to C, chromosome 7 at 102,949,257 bp
  • A to T, chromosome 7 at 104,141,635 bp
  • A to G, chromosome 8 at 11,312,586 bp
  • A to T, chromosome 8 at 94,866,512 bp
  • C to A, chromosome 9 at 66,747,631 bp
  • T to A, chromosome 10 at 128,015,263 bp
  • T to C, chromosome 11 at 9,274,702 bp
  • A to T, chromosome 11 at 22,095,462 bp
  • T to A, chromosome 11 at 23,284,634 bp
  • G to A, chromosome 11 at 50,969,869 bp
  • A to T, chromosome 11 at 56,029,561 bp
  • G to A, chromosome 11 at 73,206,493 bp
  • C to T, chromosome 11 at 73,241,682 bp
  • T to A, chromosome 11 at 73,354,305 bp
  • T to C, chromosome 11 at 83,977,152 bp
  • A to G, chromosome 11 at 103,199,836 bp
  • A to T, chromosome 12 at 51,643,223 bp
  • A to T, chromosome 12 at 51,916,150 bp
  • G to T, chromosome 12 at 84,323,020 bp
  • A to T, chromosome 12 at 98,275,235 bp
  • A to T, chromosome 12 at 98,758,514 bp
  • T to A, chromosome 12 at 117,880,025 bp
  • T to C, chromosome 12 at 117,966,639 bp
  • G to A, chromosome 13 at 30,541,107 bp
  • T to C, chromosome 13 at 98,257,925 bp
  • T to A, chromosome 13 at 100,066,037 bp
  • G to T, chromosome 14 at 57,286,408 bp
  • A to T, chromosome 14 at 75,040,820 bp
  • G to T, chromosome 14 at 103,083,212 bp
  • T to A, chromosome 15 at 35,646,181 bp
  • A to G, chromosome 15 at 97,810,851 bp
  • G to T, chromosome 16 at 11,984,767 bp
  • T to A, chromosome 16 at 28,189,611 bp
  • T to A, chromosome 17 at 25,476,511 bp
  • A to G, chromosome 17 at 30,673,835 bp
  • A to G, chromosome 17 at 46,230,343 bp
  • A to T, chromosome 17 at 56,271,888 bp
  • T to C, chromosome 18 at 13,846,240 bp
  • A to T, chromosome 18 at 38,198,657 bp
  • A to G, chromosome 18 at 58,095,176 bp
  • T to C, chromosome 18 at 60,916,665 bp
  • G to A, chromosome 19 at 5,754,022 bp
  • A to G, chromosome 19 at 45,932,349 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2263 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040263-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.