Strain Name:
C57BL/6J-MtgxR2295Btlr/Mmmh
Stock Number:
040294-MU
Citation ID:
RRID:MMRRC_040294-MU
Other Names:
R2295 (G1), C57BL/6J-MtgxR2295Btlr
Major Collection:

Gene Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Ppp1r14c
Name: protein phosphatase 1, regulatory inhibitor subunit 14C
Synonyms: 6330514J04Rik, KEPI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76142
VEGA: 10
Homologene: 12805
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56381
Homologene: 124461
Prkab1
Name: protein kinase, AMP-activated, beta 1 non-catalytic subunit
Synonyms: 1300015D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19079
HGNC: HGNC:9378
Homologene: 38160
Pip5k1c
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
Synonyms: PIP5KIgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18717
HGNC: HGNC:8996
Homologene: 69032
Dtna
Name: dystrobrevin alpha
Synonyms: alpha-dystrobrevin, A0, 87K protein, Dtn, adbn, a-DB-1, 2210407P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13527
VEGA: 18
HGNC: HGNC:3057
Homologene: 20362
Arhgap42
Name: Rho GTPase activating protein 42
Synonyms: 9030420J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71544
Homologene: 28446
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: 5230400C17Rik, Pip5k3, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18711
Homologene: 32115
Ntm
Name: neurotrimin
Synonyms: B230210G24Rik, 6230410L23Rik, Hnt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235106
Homologene: 41139
Unc119b
Name: unc-119 lipid binding chaperone B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 106840
Homologene: 43997
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100273
Homologene: 69380
Crmp1
Name: collapsin response mediator protein 1
Synonyms: Ulip3, DRP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12933
HGNC: HGNC:2365
Homologene: 20347
Olfml2b
Name: olfactomedin-like 2B
Synonyms: 1110018N05Rik, 4832415H08Rik, photomedin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320078
Homologene: 18546
Adgrd1
Name: adhesion G protein-coupled receptor D1
Synonyms: E230012M21Rik, Gpr133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243277
Homologene: 34616
Elac1
Name: elaC ribonuclease Z 1
Synonyms: 8430417G19Rik, 2610018O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 114615
Homologene: 10272
Trmt11
Name: tRNA methyltransferase 11
Synonyms: 3110045I18Rik, 2410075D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73681
VEGA: 10
Homologene: 6876
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117600
Homologene: 56898
Olfr684
Name: olfactory receptor 684
Synonyms: GA_x6K02T2PBJ9-7786441-7785503, MOR40-8P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244187
Homologene: 133596
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230613
Homologene: 136292
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: slo2, Slack, C030030G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227632
Homologene: 11055
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74441
Homologene: 65259
Il18
Name: interleukin 18
Synonyms: Il-18, Igif
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16173
VEGA: 9
HGNC: HGNC:5986
Homologene: 1200
Nfic
Name: nuclear factor I/C
Synonyms: NF1-C, 1500041O16Rik, 1110019L22Rik, nuclear factor 1-C2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18029
HGNC: HGNC:7786
Homologene: 4088
Dennd3
Name: DENN/MADD domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105841
Homologene: 28254
Olfr1497
Name: olfactory receptor 1497
Synonyms: GA_x6K02T2RE5P-4127765-4126821, MOR212-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258736
Homologene: 17373
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76713
Homologene: 66347
Hdgfl1
Name: HDGF like 1
Synonyms: HRP-1, Hdgfrp1, Pwwp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15192
Homologene: 56406
Hs6st3
Name: heparan sulfate 6-O-sulfotransferase 3
Synonyms: 6OST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50787
VEGA: 14
Homologene: 89201
Alox12
Name: arachidonate 12-lipoxygenase
Synonyms: P-12LO, Alox12p, 9930022G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11684
HGNC: HGNC:429
Homologene: 560
Luzp2
Name: leucine zipper protein 2
Synonyms: 9330154K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233271
Homologene: 45618
Polb
Name: polymerase (DNA directed), beta
Synonyms: Pol beta, A430088C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18970
HGNC: HGNC:9174
Homologene: 2013
Svopl
Name: SV2 related protein homolog (rat)-like
Synonyms: 9430071P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320590
Homologene: 52168
Hexb
Name: hexosaminidase B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15212
VEGA: 13
HGNC: HGNC:4879
Homologene: 437
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: Aatyk3, AATYK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381983
Homologene: 79449
Aldh5a1
Name: aldhehyde dehydrogenase family 5, subfamily A1
Synonyms: D630032B01Rik, OTTMUSG00000000613, 6330403E24Rik, SSADH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 214579
HGNC: HGNC:408
Homologene: 840
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68274
Homologene: 130753
Trim30d
Name: tripartite motif-containing 30D
Synonyms: TRIM30-3, Trim79
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209387
Homologene: 114426
Tekt2
Name: tektin 2
Synonyms: tektin-t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24084
Homologene: 8043
Capn15
Name: calpain 15
Synonyms: Solh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50817
Homologene: 45782
Mpped2
Name: metallophosphoesterase domain containing 2
Synonyms: 239Fb, 2700082O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77015
HGNC: HGNC:1180
Homologene: 68190
Sult2a1
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Synonyms: mSTa1, Std, Sth1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20859
Homologene: 37741
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 65,246,676 bp
  • A to G, chromosome 1 at 97,125,748 bp
  • G to A, chromosome 1 at 170,662,538 bp
  • T to C, chromosome 2 at 12,182,709 bp
  • G to T, chromosome 2 at 25,900,921 bp
  • A to G, chromosome 2 at 106,699,501 bp
  • A to G, chromosome 4 at 52,610,176 bp
  • A to G, chromosome 4 at 109,202,134 bp
  • A to T, chromosome 4 at 112,728,807 bp
  • T to C, chromosome 4 at 126,323,693 bp
  • T to C, chromosome 4 at 141,477,273 bp
  • A to G, chromosome 5 at 37,265,262 bp
  • A to C, chromosome 5 at 115,127,288 bp
  • A to T, chromosome 5 at 116,021,656 bp
  • G to A, chromosome 5 at 129,122,506 bp
  • C to A, chromosome 6 at 38,019,733 bp
  • A to G, chromosome 7 at 13,835,959 bp
  • G to A, chromosome 7 at 45,280,528 bp
  • G to T, chromosome 7 at 45,787,482 bp
  • T to C, chromosome 7 at 55,172,190 bp
  • A to C, chromosome 7 at 104,487,942 bp
  • A to G, chromosome 7 at 105,157,325 bp
  • A to G, chromosome 8 at 22,653,319 bp
  • A to T, chromosome 9 at 9,115,744 bp
  • A to G, chromosome 9 at 29,109,521 bp
  • A to G, chromosome 9 at 50,579,335 bp
  • T to C, chromosome 10 at 3,366,734 bp
  • G to C, chromosome 10 at 30,547,748 bp
  • G to A, chromosome 10 at 81,305,186 bp
  • T to C, chromosome 10 at 81,420,531 bp
  • T to C, chromosome 10 at 121,794,760 bp
  • T to C, chromosome 11 at 70,242,465 bp
  • T to C, chromosome 11 at 110,148,903 bp
  • A to G, chromosome 13 at 24,926,099 bp
  • C to T, chromosome 13 at 26,769,362 bp
  • T to C, chromosome 13 at 38,197,046 bp
  • A to G, chromosome 13 at 97,185,612 bp
  • A to G, chromosome 14 at 119,138,445 bp
  • G to A, chromosome 15 at 73,523,555 bp
  • G to A, chromosome 17 at 25,964,581 bp
  • T to G, chromosome 18 at 23,631,412 bp
  • T to C, chromosome 18 at 73,739,229 bp
  • A to T, chromosome 19 at 13,794,744 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2295 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040294-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.