Strain Name:
C57BL/6J-MtgxR2306Btlr/Mmmh
Stock Number:
040305-MU
Citation ID:
RRID:MMRRC_040305-MU
Other Names:
R2306 (G1), C57BL/6J-MtgxR2306Btlr
Major Collection:

Gene Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1-D, NFAT1, NFATp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Arhgef7
Name: Rho guanine nucleotide exchange factor (GEF7)
Synonyms: cool-1, Pak interacting exchange factor, betaPix, p85SPR, PIX, Cool, betaPix-c, betaPix-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 54126
Homologene: 2895
Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 21366
Homologene: 2291
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 21981
VEGA: 12
Homologene: 9090
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Bcat-1, Eca39, BCATc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320528
VEGA: 9
Homologene: 41188
Auts2
Name: autism susceptibility candidate 2
Synonyms: 2700063G02Rik, D830032G16Rik, A730011F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 319974
Homologene: 22907
Zfp292
Name: zinc finger protein 292
Synonyms: 5730450D02Rik, Zfp15, 9430062L07Rik, Krox-10, Zfp-15, Zn-16, Zn-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 30046
Homologene: 8493
Ifitm2
Name: interferon induced transmembrane protein 2
Synonyms: mil-3, fragilis3, Ifitm3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 80876
HGNC: HGNC:5413
Homologene: 74574
Unc119b
Name: unc-119 lipid binding chaperone B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 106840
Homologene: 43997
Syt13
Name: synaptotagmin XIII
Synonyms: 5730409J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 80976
Homologene: 10823
Crispld2
Name: cysteine-rich secretory protein LCCL domain containing 2
Synonyms: coffeecrisp, Lgl1, 1810049K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 78892
Homologene: 41792
Mme
Name: membrane metallo endopeptidase
Synonyms: neprilysin, NEP, neutral endopeptidase, CD10, 6030454K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Sfr1
Name: SWI5 dependent recombination repair 1
Synonyms: 6330577E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67788
VEGA: 19
Homologene: 12189
Tmem231
Name: transmembrane protein 231
Synonyms: 4932417I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234740
Homologene: 78035
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Rbp-3, Irbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: USH1D, mdfw, ahl, nmf112, nmf181, nmf252, 4930542A03Rik, sals, bob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22295
Homologene: 11142
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 58178
Homologene: 10967
Atmin
Name: ATM interactor
Synonyms: Asciz, gpg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234776
Homologene: 35321
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, Heatr7b1, OTTMUSG00000020804
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100040766
Homologene: 85300
C4b
Name: complement component 4B (Chido blood group)
Synonyms: C4, Ss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12268
Homologene: 36030
Npr2
Name: natriuretic peptide receptor 2
Synonyms: guanylyl cyclase-B, cn, pwe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230103
HGNC: HGNC:7944
Homologene: 2970
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
Dnaic1
Name: dynein, axonemal, intermediate chain 1
Synonyms: b2b1526Clo, 1110066F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68922
HGNC: HGNC:2954
Homologene: 8122
Rfc3
Name: replication factor C (activator 1) 3
Synonyms: 2810416I22Rik, Recc3, 38kDa, 38kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69263
HGNC: HGNC:9971
Homologene: 2188
Tmem247
Name: transmembrane protein 247
Synonyms: 1700090G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78469
Homologene: 54379
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330222
Homologene: 27395
Mark1
Name: MAP/microtubule affinity regulating kinase 1
Synonyms: B930025N23Rik, Emk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226778
HGNC: HGNC:6896
Homologene: 49552
Vmn1r196
Name: vomeronasal 1 receptor 196
Synonyms: V1rh19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 100312484
Homologene: 110880
Tmem19
Name: transmembrane protein 19
Synonyms: 2810428F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67226
VEGA: 10
Homologene: 10107
Adgrf2
Name: adhesion G protein-coupled receptor F2
Synonyms: Gpr111, PGR20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 435529
Homologene: 45213
Ctsw
Name: cathepsin W
Synonyms: lymphopain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 13041
VEGA: 19
HGNC: HGNC:2546
Homologene: 37471
Pax8
Name: paired box 8
Synonyms: Pax-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18510
HGNC: HGNC:8622
Homologene: 2589
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • A to T, chromosome 1 at 184,900,861 bp
  • T to A, chromosome 2 at 24,443,045 bp
  • G to A, chromosome 2 at 92,940,967 bp
  • G to C, chromosome 2 at 98,664,007 bp
  • A to C, chromosome 2 at 168,590,103 bp
  • A to G, chromosome 3 at 63,300,252 bp
  • C to A, chromosome 4 at 34,809,468 bp
  • T to C, chromosome 4 at 41,625,239 bp
  • T to A, chromosome 4 at 43,633,609 bp
  • T to G, chromosome 5 at 21,896,786 bp
  • A to T, chromosome 5 at 115,125,475 bp
  • T to C, chromosome 5 at 131,470,404 bp
  • C to T, chromosome 5 at 141,962,700 bp
  • A to G, chromosome 5 at 151,643,778 bp
  • A to G, chromosome 6 at 91,748,484 bp
  • A to G, chromosome 6 at 145,007,653 bp
  • T to A, chromosome 7 at 140,955,789 bp
  • T to A, chromosome 8 at 11,812,680 bp
  • A to T, chromosome 8 at 111,918,871 bp
  • T to C, chromosome 8 at 116,957,650 bp
  • T to G, chromosome 8 at 120,026,071 bp
  • T to A, chromosome 9 at 67,987,993 bp
  • A to G, chromosome 10 at 60,323,445 bp
  • A to G, chromosome 10 at 115,343,686 bp
  • T to C, chromosome 12 at 111,844,893 bp
  • T to A, chromosome 13 at 22,293,303 bp
  • A to T, chromosome 14 at 33,962,563 bp
  • T to G, chromosome 17 at 34,728,518 bp
  • G to A, chromosome 17 at 42,713,119 bp
  • C to A, chromosome 17 at 86,918,441 bp
  • T to C, chromosome 19 at 5,466,982 bp
  • T to C, chromosome 19 at 47,734,852 bp
  • G to A, chromosome 19 at 50,252,524 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2306 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040305-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.