Strain Name:
C57BL/6J-MtgxR2307Btlr/Mmmh
Stock Number:
040306-MU
Citation ID:
RRID:MMRRC_040306-MU
Other Names:
R2307 (G1), C57BL/6J-MtgxR2307Btlr
Major Collection:

Strain Information

Dnajc3
Name: DnaJ heat shock protein family (Hsp40) member C3
Synonyms: p58IPK, mp58, Prkri, Dnajc3, Dnajc3a, Dnajc3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100037258
VEGA: 14
HGNC: HGNC:9439
Homologene: 2486
Cmtm5
Name: CKLF-like MARVEL transmembrane domain containing 5
Synonyms: 2900052H21Rik, 1500005P16Rik, Cklfsf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67272
VEGA: 14
Homologene: 16322
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242443
Homologene: 128613
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Zfp294, Listerin, Rnf160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: 1190005L06Rik, A730023M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68925
Homologene: 32269
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226747
Homologene: 9142
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213895
Homologene: 7065
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Orc3
Name: origin recognition complex, subunit 3
Synonyms: Orc3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50793
HGNC: HGNC:8489
Homologene: 8225
Mcm2
Name: minichromosome maintenance complex component 2
Synonyms: CDCL1, BM28, Mcmd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17216
HGNC: HGNC:6944
Homologene: 3325
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: C730024G01Rik, 2700017A04Rik, Brctx, Brctd1, Ankrd32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105377
Homologene: 13000
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: PTIP, D5Ertd149e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 55982
HGNC: HGNC:8624
Inpp5f
Name: inositol polyphosphate-5-phosphatase F
Synonyms: cI-27, SAC2, 5830435P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101490
Homologene: 8962
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
St6galnac2
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Synonyms: ST6GalNAc II, Siat7, Siat7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20446
Homologene: 4714
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Prf1
Name: perforin 1 (pore forming protein)
Synonyms: perforin, Prf-1, Pfp, Pfn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18646
VEGA: 10
HGNC: HGNC:9360
Homologene: 3698
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: 8-LOX, e-LOX1, Alox12-ps1, Aloxe, Alox12-ps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11685
Homologene: 105868
H2-K1
Name: histocompatibility 2, K1, K region
Synonyms: H-2K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14972
Homologene: 128352
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Mep1b
Name: meprin 1 beta
Synonyms: meprin beta, Mep-1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Unc13b
Name: unc-13 homolog B
Synonyms: Unc13h2, Munc13-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22249
Homologene: 31376
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: LOC381229, Ccdc147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Psmb9
Name: proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
Synonyms: Lmp-2, Lmp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16912
HGNC: HGNC:9546
Homologene: 2094
Kif1a
Name: kinesin family member 1A
Synonyms: Kns1, ATSV, N-3 kinesin, LOC381283, C630002N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Ces2g
Name: carboxylesterase 2G
Synonyms: 2210023G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72361
HGNC: HGNC:1864
Homologene: 77154
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241514
Homologene: 18461
Ddhd1
Name: DDHD domain containing 1
Synonyms: 9630061G18Rik, 4921528E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 114874
Homologene: 35221
Gxylt2
Name: glucoside xylosyltransferase 2
Synonyms: LOC232313, Glt8d4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232313
Homologene: 16823
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66898
Homologene: 23123
Vmn1r20
Name: vomeronasal 1 receptor 20
Synonyms: Gm5569
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434017
Homologene: 79462
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Syce1l
Name: synaptonemal complex central element protein 1 like
Synonyms: 4930481F22Rik, mmrp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 668110
Homologene: 86343
Prorp
Name: protein only RNase P catalytic subunit
Synonyms: Mrpp3, 1110008L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66132
Homologene: 45935
Krt24
Name: keratin 24
Synonyms: 2310075C18Rik, 2310058N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75706
Homologene: 10379
Smarcd3
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Synonyms: 1500001J14Rik, BAF60C, 2210409C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66993
Homologene: 2314
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt-2, Astt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Clcnkb
Name: chloride channel, voltage-sensitive Kb
Synonyms: Clcnk1l, Clck2, ClC-K2, Clcnk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56365
HGNC: HGNC:2027
Homologene: 107317
Sec16b
Name: SEC16 homolog B (S. cerevisiae)
Synonyms: Rgpr-p117, Rgpr, Lztr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 89867
Homologene: 13227
Tcam1
Name: testicular cell adhesion molecule 1
Synonyms: 4930570F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75870
Homologene: 123944
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Prss40
Name: protease, serine 40
Synonyms: Tesp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21756
Homologene: 69043
Fgf14
Name: fibroblast growth factor 14
Synonyms: Fhf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14169
HGNC: HGNC:3671
Homologene: 3037
Ugt1a10
Name: UDP glycosyltransferase 1 family, polypeptide A10
Synonyms: A13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394430
Homologene: 133281
Galnt17
Name: polypeptide N-acetylgalactosaminyltransferase 17
Synonyms: E330012B09Rik, Gcap8, Galnt19, Wbscr17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212996
Homologene: 49707
Acot5
Name: acyl-CoA thioesterase 5
Synonyms: PTE-Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217698
Homologene: 77351
Prss53
Name: protease, serine 53
Synonyms: BC039632
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330657
Homologene: 80097
Rnase2b
Name: ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)
Synonyms: murine ribonuclease 5, mR5, Ear5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54159
VEGA: 14
Homologene: 121614
Rrnad1
Name: ribosomal RNA adenine dimethylase domain containing 1
Synonyms: BC023814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229503
Homologene: 9332
B430306N03Rik
Name: RIKEN cDNA B430306N03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320148
Homologene: 138443
Cltb
Name: clathrin, light polypeptide (Lcb)
Synonyms: 2310046E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74325
HGNC: HGNC:2091
Homologene: 37532
Krtap5-4
Name: keratin associated protein 5-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 50775
Ubl5
Name: ubiquitin-like 5
Synonyms: 1110030M22Rik, BEACON, Ubl5a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66177
Homologene: 83305
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 14,912,381 bp
  • T to G, chromosome 1 at 34,544,755 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • A to G, chromosome 1 at 88,055,947 bp
  • G to T, chromosome 1 at 93,078,769 bp
  • G to A, chromosome 1 at 157,535,492 bp
  • T to C, chromosome 1 at 179,770,950 bp
  • G to A, chromosome 2 at 76,886,998 bp
  • T to A, chromosome 2 at 82,256,857 bp
  • G to A, chromosome 2 at 119,783,766 bp
  • A to T, chromosome 3 at 87,926,855 bp
  • C to T, chromosome 4 at 34,586,503 bp
  • A to G, chromosome 4 at 43,239,854 bp
  • C to T, chromosome 4 at 49,793,033 bp
  • A to G, chromosome 4 at 141,412,329 bp
  • T to A, chromosome 5 at 14,678,651 bp
  • C to T, chromosome 5 at 24,595,748 bp
  • C to T, chromosome 5 at 27,744,185 bp
  • T to G, chromosome 5 at 130,900,622 bp
  • T to C, chromosome 5 at 137,609,094 bp
  • T to A, chromosome 5 at 144,324,544 bp
  • C to T, chromosome 6 at 57,432,136 bp
  • G to A, chromosome 6 at 88,893,008 bp
  • A to G, chromosome 6 at 100,787,212 bp
  • C to T, chromosome 6 at 118,418,396 bp
  • T to C, chromosome 6 at 125,992,886 bp
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp
  • T to C, chromosome 7 at 127,890,865 bp
  • T to C, chromosome 7 at 128,694,310 bp
  • C to A, chromosome 7 at 142,303,614 bp
  • A to G, chromosome 8 at 104,968,412 bp
  • T to C, chromosome 8 at 113,643,305 bp
  • T to A, chromosome 9 at 20,646,580 bp
  • T to C, chromosome 10 at 61,303,163 bp
  • T to C, chromosome 11 at 70,321,261 bp
  • T to C, chromosome 11 at 99,284,630 bp
  • T to C, chromosome 11 at 106,284,114 bp
  • C to T, chromosome 11 at 116,681,905 bp
  • T to C, chromosome 12 at 55,304,316 bp
  • T to C, chromosome 12 at 84,075,601 bp
  • T to A, chromosome 13 at 54,598,751 bp
  • T to C, chromosome 13 at 77,112,562 bp
  • A to T, chromosome 14 at 45,608,990 bp
  • A to G, chromosome 14 at 51,162,731 bp
  • T to G, chromosome 14 at 54,938,942 bp
  • T to C, chromosome 14 at 118,953,221 bp
  • T to A, chromosome 14 at 123,983,822 bp
  • A to G, chromosome 16 at 87,432,424 bp
  • A to G, chromosome 17 at 33,997,139 bp
  • G to A, chromosome 17 at 34,183,759 bp
  • T to A, chromosome 17 at 46,966,215 bp
  • C to T, chromosome 17 at 48,321,113 bp
  • A to T, chromosome 18 at 21,088,575 bp
  • A to G, chromosome 18 at 67,813,899 bp
  • C to T, chromosome 19 at 47,962,486 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2307 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040306-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.