Strain Name:
C57BL/6J-MtgxR2340Btlr/Mmmh
Stock Number:
040326-MU
Citation ID:
RRID:MMRRC_040326-MU
Other Names:
R2340 (G1), C57BL/6J-MtgxR2340Btlr
Major Collection:

Gene Information

Lypd2
Name: Ly6/Plaur domain containing 2
Synonyms: 0610005K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68311
Homologene: 19022
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74315
Homologene: 14427
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: LOC380993, Zfp406, Zfat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380993
Homologene: 16829
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Rcan1
Name: regulator of calcineurin 1
Synonyms: MCIP1, 2410048A02Rik, ADAPT78, CSP1, Dscr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 54720
VEGA: 16
HGNC: HGNC:3040
Homologene: 3251
Rnf216
Name: ring finger protein 216
Synonyms: UIP83, F830018F18Rik, 2810055G22Rik, Ubce7ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108086
Homologene: 19442
Kif2c
Name: kinesin family member 2C
Synonyms: 4930402F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73804
HGNC: HGNC:6393
Homologene: 21355
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Midn
Name: midnolin
Synonyms: 3000003C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 59090
Homologene: 32510
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Tmem184b
Name: transmembrane protein 184b
Synonyms: 4732495E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223693
VEGA: 15
HGNC: HGNC:1310
Homologene: 6396
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Tnnt1
Name: troponin T1, skeletal, slow
Synonyms: Tnt, skeletal muscle slow-twitch TnT, sTnT, ssTnT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21955
Homologene: 20704
Clu
Name: clusterin
Synonyms: testosterone repressed prostate message-2, SP-40, complement lysis inhibitor, Sgp-2, ApoJ, Apolipoprotein J, Cli, Sugp-2, Sgp2, D14Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12759
HGNC: HGNC:2095
Homologene: 1382
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: 4930556H18Rik, 1700048H13Rik, 2310009M18Rik, D630041K24Rik, STAMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320244
Homologene: 9013
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: GlcT-1, Epcs21, Ugcgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22234
Homologene: 37763
D930020B18Rik
Name: RIKEN cDNA D930020B18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216393
Homologene: 87610
Olfr954
Name: olfactory receptor 954
Synonyms: GA_x6K02T2PVTD-33158015-33158950, MOR171-42, MOR171-53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258328
VEGA: 9
Homologene: 71961
Spock3
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
Synonyms: testican 3, 2900045C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72902
Homologene: 9662
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108151
Homologene: 23664
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Oatp2, Slc21a5, Oatp1a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28250
Homologene: 130782
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, 2700017I06Rik, Gm13190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209630
Homologene: 9971
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Olfr1497
Name: olfactory receptor 1497
Synonyms: GA_x6K02T2RE5P-4127765-4126821, MOR212-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258736
Homologene: 17373
Rad51d
Name: RAD51 paralog D
Synonyms: R51H3, Rad51l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19364
HGNC: HGNC:9823
Homologene: 2156
B3glct
Name: beta-3-glucosyltransferase
Synonyms: LOC381694, B3galtl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381694
Homologene: 14978
Ccno
Name: cyclin O
Synonyms: Ung2, Ccnu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218630
VEGA: 13
Homologene: 50171
Serpina11
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
Synonyms: LOC380780
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 380780
Homologene: 28490
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Rph3al
Name: rabphilin 3A-like (without C2 domains)
Synonyms: 6530413F01Rik, LOC385671, Noc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380714
Homologene: 5078
Olfr11
Name: olfactory receptor 11
Synonyms: MOR256-11, GA_x6K02T2QHY8-11597382-11598323
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Fam189a1
Name: family with sequence similarity 189, member A1
Synonyms: 5730507A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70638
Homologene: 77705
Zfp606
Name: zinc finger protein 606
Synonyms: 2410022M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67370
Homologene: 23514
Hacd1
Name: 3-hydroxyacyl-CoA dehydratase 1
Synonyms: Ptpla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 30963
HGNC: HGNC:9639
Homologene: 69153
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,200,855 bp
  • T to A, chromosome 1 at 93,256,452 bp
  • G to T, chromosome 1 at 184,731,987 bp
  • C to T, chromosome 1 at 194,749,317 bp
  • A to G, chromosome 2 at 4,586,376 bp
  • G to T, chromosome 2 at 14,035,887 bp
  • TG to T, chromosome 2 at 160,965,759 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • A to G, chromosome 4 at 117,169,841 bp
  • T to C, chromosome 5 at 12,568,274 bp
  • A to T, chromosome 5 at 143,080,334 bp
  • A to G, chromosome 5 at 149,745,440 bp
  • C to A, chromosome 6 at 141,841,377 bp
  • G to A, chromosome 7 at 4,513,616 bp
  • A to G, chromosome 7 at 12,493,089 bp
  • A to G, chromosome 7 at 64,775,817 bp
  • T to A, chromosome 8 at 63,345,713 bp
  • A to G, chromosome 9 at 7,136,989 bp
  • A to G, chromosome 9 at 39,461,809 bp
  • G to T, chromosome 10 at 80,150,112 bp
  • A to G, chromosome 10 at 121,654,836 bp
  • A to T, chromosome 11 at 9,399,165 bp
  • T to C, chromosome 11 at 44,531,378 bp
  • A to T, chromosome 11 at 55,270,096 bp
  • T to C, chromosome 11 at 75,833,432 bp
  • T to C, chromosome 11 at 82,881,821 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • T to A, chromosome 12 at 85,892,148 bp
  • T to C, chromosome 12 at 103,984,743 bp
  • T to C, chromosome 13 at 21,638,587 bp
  • G to T, chromosome 13 at 112,989,089 bp
  • T to C, chromosome 14 at 65,980,909 bp
  • T to C, chromosome 15 at 68,101,541 bp
  • T to A, chromosome 15 at 74,734,254 bp
  • T to A, chromosome 15 at 79,378,532 bp
  • A to G, chromosome 16 at 92,397,352 bp
  • T to A, chromosome 17 at 22,603,115 bp
  • T to A, chromosome 18 at 20,267,888 bp
  • T to A, chromosome 18 at 57,900,050 bp
  • A to G, chromosome 19 at 13,794,771 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2340 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040326-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.