Strain Name:
C57BL/6J-MtgxR2340Btlr/Mmmh
Stock Number:
040326-MU
Citation ID:
RRID:MMRRC_040326-MU
Other Names:
R2340 (G1), C57BL/6J-MtgxR2340Btlr
Major Collection:

Strain Information

Lypd2
Name: Ly6/Plaur domain containing 2
Synonyms: 0610005K03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68311
Homologene: 19022
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74315
Homologene: 14427
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfat1, Zfp406, LOC380993
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: Nkcc1, mBSC2, sodium/potassium/chloride cotransporters, sy-ns
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Rcan1
Name: regulator of calcineurin 1
Synonyms: MCIP1, CSP1, Dscr1, 2410048A02Rik, ADAPT78
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54720
VEGA: 16
HGNC: HGNC:3040
Homologene: 3251
Rnf216
Name: ring finger protein 216
Synonyms: F830018F18Rik, UIP83, Ubce7ip1, 2810055G22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108086
Homologene: 19442
Kif2c
Name: kinesin family member 2C
Synonyms: 4930402F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73804
HGNC: HGNC:6393
Homologene: 21355
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Midn
Name: midnolin
Synonyms: 3000003C15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59090
Homologene: 32510
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: Ta3, talpid3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76967
Homologene: 8839
Tmem184b
Name: transmembrane protein 184b
Synonyms: 4732495E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223693
VEGA: 15
HGNC: HGNC:1310
Homologene: 6396
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Tnnt1
Name: troponin T1, skeletal, slow
Synonyms: Tnt, ssTnT, sTnT, skeletal muscle slow-twitch TnT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21955
Homologene: 20704
Clu
Name: clusterin
Synonyms: SP-40, ApoJ, Apolipoprotein J, Cli, testosterone repressed prostate message-2, complement lysis inhibitor, D14Ucla3, Sgp2, Sugp-2, Sgp-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12759
HGNC: HGNC:2095
Homologene: 1382
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: STAMP, 4930556H18Rik, 2310009M18Rik, 1700048H13Rik, D630041K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: Ugcgl, GlcT-1, Epcs21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22234
Homologene: 37763
D930020B18Rik
Name: RIKEN cDNA D930020B18 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216393
Homologene: 87610
Or8g34
Name: olfactory receptor family 8 subfamily G member 34
Synonyms: MOR171-42, MOR171-53, Olfr954, GA_x6K02T2PVTD-33158015-33158950
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258328
VEGA: 9
HGNC: HGNC:8484
Homologene: 71961
Spock3
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
Synonyms: testican 3, 2900045C01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72902
Homologene: 9662
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108151
Homologene: 23664
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Slc21a5, Oatp1a4, Oatp2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28250
Homologene: 130782
Frmd4a
Name: FERM domain containing 4A
Synonyms: Gm13190, 2700017I06Rik, C230040M21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Or9q2
Name: olfactory receptor family 9 subfamily Q member 2
Synonyms: MOR212-1, Olfr1497, GA_x6K02T2RE5P-4127765-4126821
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258736
Homologene: 17373
Rad51d
Name: RAD51 paralog D
Synonyms: R51H3, Rad51l3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19364
HGNC: HGNC:9823
Homologene: 2156
B3glct
Name: beta-3-glucosyltransferase
Synonyms: LOC381694, B3galtl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381694
Homologene: 14978
Ccno
Name: cyclin O
Synonyms: Ccnu, Ung2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218630
VEGA: 13
Homologene: 50171
Serpina11
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
Synonyms: LOC380780
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380780
Homologene: 28490
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: Snep, 6720455I24Rik, D430044C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208777
Homologene: 14708
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 628185
Homologene: 86604
Rph3al
Name: rabphilin 3A-like (without C2 domains)
Synonyms: Noc2, 6530413F01Rik, LOC385671
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380714
Homologene: 5078
Or2b6
Name: olfactory receptor family 2 subfamily B member 6
Synonyms: GA_x6K02T2QHY8-11597382-11598323, Olfr11, MOR256-11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Entrep2
Name: endosomal transmembrane epsin interactor 2
Synonyms: 5730507A09Rik, Fam189a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70638
Homologene: 77705
Zfp606
Name: zinc finger protein 606
Synonyms: 2410022M24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67370
Homologene: 23514
Hacd1
Name: 3-hydroxyacyl-CoA dehydratase 1
Synonyms: Ptpla
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30963
HGNC: HGNC:9639
Homologene: 69153
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,200,855 bp
  • T to A, chromosome 1 at 93,256,452 bp
  • G to T, chromosome 1 at 184,731,987 bp
  • C to T, chromosome 1 at 194,749,317 bp
  • A to G, chromosome 2 at 4,586,376 bp
  • G to T, chromosome 2 at 14,035,887 bp
  • TG to T, chromosome 2 at 160,965,759 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • A to G, chromosome 4 at 117,169,841 bp
  • T to C, chromosome 5 at 12,568,274 bp
  • A to T, chromosome 5 at 143,080,334 bp
  • A to G, chromosome 5 at 149,745,440 bp
  • C to A, chromosome 6 at 141,841,377 bp
  • G to A, chromosome 7 at 4,513,616 bp
  • A to G, chromosome 7 at 12,493,089 bp
  • A to G, chromosome 7 at 64,775,817 bp
  • T to A, chromosome 8 at 63,345,713 bp
  • A to G, chromosome 9 at 7,136,989 bp
  • A to G, chromosome 9 at 39,461,809 bp
  • G to T, chromosome 10 at 80,150,112 bp
  • A to G, chromosome 10 at 121,654,836 bp
  • A to T, chromosome 11 at 9,399,165 bp
  • T to C, chromosome 11 at 44,531,378 bp
  • A to T, chromosome 11 at 55,270,096 bp
  • T to C, chromosome 11 at 75,833,432 bp
  • T to C, chromosome 11 at 82,881,821 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • T to A, chromosome 12 at 85,892,148 bp
  • T to C, chromosome 12 at 103,984,743 bp
  • T to C, chromosome 13 at 21,638,587 bp
  • G to T, chromosome 13 at 112,989,089 bp
  • T to C, chromosome 14 at 65,980,909 bp
  • T to C, chromosome 15 at 68,101,541 bp
  • T to A, chromosome 15 at 74,734,254 bp
  • T to A, chromosome 15 at 79,378,532 bp
  • A to G, chromosome 16 at 92,397,352 bp
  • T to A, chromosome 17 at 22,603,115 bp
  • T to A, chromosome 18 at 20,267,888 bp
  • T to A, chromosome 18 at 57,900,050 bp
  • A to G, chromosome 19 at 13,794,771 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2340 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040326-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.