Strain Name:
C57BL/6J-MtgxR2341Btlr/Mmmh
Stock Number:
040327-MU
Citation ID:
RRID:MMRRC_040327-MU
Other Names:
R2341 (G1), C57BL/6J-MtgxR2341Btlr
Major Collection:

Strain Information

Anxa4
Name: annexin A4
Synonyms: Anx4, Xanx-4, annexin IV, AIV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11746
HGNC: HGNC:542
Homologene: 68164
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Usp30
Name: ubiquitin specific peptidase 30
Synonyms: 6330590F17Rik, D5Ertd483e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100756
Homologene: 32789
Ythdf3
Name: YTH N6-methyladenosine RNA binding protein 3
Synonyms: 9130022A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229096
Homologene: 34991
Sipa1l3
Name: signal-induced proliferation-associated 1 like 3
Synonyms: 2610511M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74206
Homologene: 77938
Vps35
Name: VPS35 retromer complex component
Synonyms: Mem3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 65114
Homologene: 6221
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227195
Homologene: 9819
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: 5133400C09Rik, breakpoint cluster region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: 2610306D21Rik, APC4, D5Ertd249e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52206
Homologene: 40873
Ifna16
Name: interferon alpha 16
Synonyms: Ifna6t, Gm13280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230398
Homologene: 68536
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Prkce
Name: protein kinase C, epsilon
Synonyms: PKC[e], Pkce, 5830406C15Rik, PKCepsilon, PCK epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17836
Homologene: 136663
Or8h8
Name: olfactory receptor family 8 subfamily H member 8
Synonyms: GA_x6K02T2Q125-48410458-48409511, MOR206-1, Olfr1098
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258842
Homologene: 37005
Zfp110
Name: zinc finger protein 110
Synonyms: NRIF, 2900024E01Rik, Nrif1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 65020
Homologene: 129707
Xkr7
Name: X-linked Kx blood group related 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228787
Homologene: 19390
Ms4a20
Name: membrane-spanning 4-domains, subfamily A, member 20
Synonyms: 1700017D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69369
Rnf43
Name: ring finger protein 43
Synonyms: 4732452J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207742
Homologene: 37742
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71276
Homologene: 52351
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Scel
Name: sciellin
Synonyms: 9230114I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 64929
VEGA: 14
Homologene: 2850
Sun5
Name: Sad1 and UNC84 domain containing 5
Synonyms: 1700021O15Rik, Spag4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76407
Homologene: 12640
Aif1
Name: allograft inflammatory factor 1
Synonyms: G1, Iba1, D17H6S50E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11629
HGNC: HGNC:352
Homologene: 1226
Rnf144b
Name: ring finger protein 144B
Synonyms: E130105P19Rik, Ibrdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218215
VEGA: 13
Homologene: 27092
4933412E24Rik
Name: RIKEN cDNA 4933412E24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71088
VEGA: 15
Homologene: 129990
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Or10ag57
Name: olfactory receptor family 10 subfamily AG member 57
Synonyms: GA_x6K02T2Q125-48880078-48881058, MOR264-1, Olfr1122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259033
Homologene: 73977
Nedd9
Name: neural precursor cell expressed, developmentally down-regulated gene 9
Synonyms: E230025G09Rik, CasL, HEF1, Cas-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18003
VEGA: 13
HGNC: HGNC:7733
Homologene: 4669
H2-T3
Name: histocompatibility 2, T region locus 3
Synonyms: H-2T3, TL, H2-Tw3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15043
Homologene: 74884
Scn4b
Name: sodium channel, type IV, beta
Synonyms: LOC384934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 399548
Homologene: 18384
Gm5444
Name: predicted gene 5444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Or4c11b
Name: olfactory receptor family 4 subfamily C member 11B
Synonyms: GA_x6K02T2Q125-50268830-50269753, MOR230-2, Olfr1201
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258897
Homologene: 81567
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 63,065,826 bp
  • G to T, chromosome 1 at 184,731,987 bp
  • T to C, chromosome 2 at 86,922,638 bp
  • A to T, chromosome 2 at 87,387,740 bp
  • A to G, chromosome 2 at 88,794,645 bp
  • T to A, chromosome 2 at 121,025,730 bp
  • G to A, chromosome 2 at 153,054,398 bp
  • A to G, chromosome 2 at 153,867,502 bp
  • TG to T, chromosome 2 at 160,965,759 bp
  • A to T, chromosome 3 at 16,203,215 bp
  • T to C, chromosome 4 at 56,937,957 bp
  • A to G, chromosome 4 at 88,676,328 bp
  • T to C, chromosome 5 at 52,841,937 bp
  • A to T, chromosome 5 at 110,330,963 bp
  • C to T, chromosome 5 at 114,111,180 bp
  • A to G, chromosome 6 at 86,743,153 bp
  • T to C, chromosome 6 at 121,884,629 bp
  • T to C, chromosome 7 at 12,849,186 bp
  • T to C, chromosome 7 at 29,377,635 bp
  • T to C, chromosome 8 at 85,274,814 bp
  • A to G, chromosome 9 at 21,839,486 bp
  • G to A, chromosome 9 at 45,147,829 bp
  • A to G, chromosome 10 at 75,131,112 bp
  • A to G, chromosome 11 at 87,732,025 bp
  • T to C, chromosome 11 at 105,835,051 bp
  • T to C, chromosome 11 at 120,860,523 bp
  • T to C, chromosome 12 at 55,677,124 bp
  • T to C, chromosome 12 at 84,809,163 bp
  • T to C, chromosome 13 at 4,834,345 bp
  • A to G, chromosome 13 at 41,316,511 bp
  • A to G, chromosome 13 at 47,220,500 bp
  • A to T, chromosome 14 at 103,608,170 bp
  • A to G, chromosome 15 at 60,016,363 bp
  • T to A, chromosome 17 at 22,603,115 bp
  • G to A, chromosome 17 at 35,172,151 bp
  • C to T, chromosome 17 at 36,189,328 bp
  • C to A, chromosome 17 at 86,474,442 bp
  • T to A, chromosome 19 at 11,105,793 bp
  • A to G, chromosome 19 at 25,200,393 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2341 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040327-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.