Strain Name:
C57BL/6J-MtgxR2354Btlr/Mmmh
Stock Number:
040336-MU
Citation ID:
RRID:MMRRC_040336-MU
Other Names:
R2354 (G1), C57BL/6J-MtgxR2354Btlr
Major Collection:

Gene Information

D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330286
Homologene: 19782
Hap1
Name: huntingtin-associated protein 1
Synonyms: HAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15114
HGNC: HGNC:4812
Homologene: 2935
Epb41l3
Name: erythrocyte membrane protein band 4.1 like 3
Synonyms: NBL3, Epb4.1l3, 4.1B, DAL1P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 13823
HGNC: HGNC:3380
Homologene: 49308
Ddb1
Name: damage specific DNA binding protein 1
Synonyms: p127-Ddb1, DNA repair protein, damage-specific DNA-binding protein, DNA repair
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 13194
VEGA: 19
HGNC: HGNC:2717
Homologene: 1448
Neo1
Name: neogenin
Synonyms: Igdcc2, 2610028H22Rik, D930014N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
Mmp16
Name: matrix metallopeptidase 16
Synonyms: Membrane type 3-MMP, MT3-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Synonyms: MS, D830038K18Rik, methionine synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238505
VEGA: 13
HGNC: HGNC:7468
Homologene: 37280
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 170643
Homologene: 10089
Lmbrd1
Name: LMBR1 domain containing 1
Synonyms: 0910001K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68421
Homologene: 10156
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233979
Homologene: 16375
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: 0910001L17Rik, A930007H10Rik, C820010P03Rik, Ugcgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320011
Homologene: 10586
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319675
Homologene: 27936
Umod
Name: uromodulin
Synonyms: Tamm-Horsfall glycoprotein, uromucoid, Urehd1, urehr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22242
Homologene: 2522
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 212124
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: ESTM26, R74981, beta4GalT-III, 9530061M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Zc3h12d
Name: zinc finger CCCH type containing 12D
Synonyms: D730019B10Rik, TFL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237256
VEGA: 10
Homologene: 18225
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: beta3B, Naptb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74978
Homologene: 46007
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: RDGBA2, Rdgb2, NIR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19679
Homologene: 7915
Taar4
Name: trace amine-associated receptor 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 209513
Homologene: 45509
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227058
Homologene: 41287
Cd226
Name: CD226 antigen
Synonyms: Pta1, TLiSA1, DNAM-1, DNAM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225825
Homologene: 4787
Bpifb9b
Name: BPI fold containing family B, member 9B
Synonyms: OTTMUSG00000015915, 5430413K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 433492
Homologene: 128535
Slc28a3
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Synonyms: Cnt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 114304
Homologene: 32533
Hif3a
Name: hypoxia inducible factor 3, alpha subunit
Synonyms: Nepas, bHLHe17, MOP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 53417
Homologene: 9646
Dyrk1b
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
Synonyms: Mirk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13549
HGNC: HGNC:3092
Homologene: 31253
Galk2
Name: galactokinase 2
Synonyms: Gk2, 2810017M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69976
HGNC: HGNC:4119
Homologene: 13654
Shox2
Name: short stature homeobox 2
Synonyms: Prx3, 6330543G17Rik, Og12x
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20429
Homologene: 68535
Cdh15
Name: cadherin 15
Synonyms: Mcad, Cdh14, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Zkscan7
Name: zinc finger with KRAB and SCAN domains 7
Synonyms: Zfp167
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382118
VEGA: 9
Homologene: 83284
1110020G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
Sstr5
Name: somatostatin receptor 5
Synonyms: sst5, Smstr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20609
VEGA: 17
Homologene: 20287
4930444G20Rik
Name: RIKEN cDNA 4930444G20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 114671
Homologene: 130042
Gal3st2b
Name: galactose-3-O-sulfotransferase 2B
Synonyms: Gm9994
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100041596
Homologene: 41471
Slc5a12
Name: solute carrier family 5 (sodium/glucose cotransporter), member 12
Synonyms: SMCT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241612
Homologene: 15107
Zfp358
Name: zinc finger protein 358
Synonyms: Zfend
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 140482
Homologene: 9996
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434113
Homologene: 113703
Gm6169
Name: predicted gene 6169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 620648
VEGA: 13
Mup-ps18
Name: major urinary protein, pseudogene 18
Synonyms: Gm12562
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 667295
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 24,685,541 bp
  • A to G, chromosome 1 at 24,743,961 bp
  • C to A, chromosome 1 at 36,163,424 bp
  • CTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTT to CTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTT, chromosome 1 at 46,116,096 bp
  • A to G, chromosome 1 at 93,939,786 bp
  • C to A, chromosome 1 at 171,274,043 bp
  • T to C, chromosome 2 at 110,609,432 bp
  • C to A, chromosome 2 at 125,931,273 bp
  • C to T, chromosome 2 at 154,311,742 bp
  • A to G, chromosome 3 at 66,981,489 bp
  • C to T, chromosome 3 at 87,088,485 bp
  • A to G, chromosome 4 at 18,112,001 bp
  • G to A, chromosome 4 at 61,875,447 bp
  • C to G, chromosome 4 at 121,054,258 bp
  • A to T, chromosome 5 at 124,122,919 bp
  • G to A, chromosome 6 at 38,158,091 bp
  • T to G, chromosome 7 at 8,370,640 bp
  • T to C, chromosome 7 at 17,041,105 bp
  • G to A, chromosome 7 at 28,185,372 bp
  • C to T, chromosome 7 at 81,473,850 bp
  • C to T, chromosome 7 at 119,466,193 bp
  • T to C, chromosome 7 at 139,661,046 bp
  • C to A, chromosome 7 at 145,257,218 bp
  • A to T, chromosome 8 at 3,495,454 bp
  • G to A, chromosome 8 at 122,862,024 bp
  • A to G, chromosome 9 at 15,334,784 bp
  • A to G, chromosome 9 at 58,985,634 bp
  • A to G, chromosome 9 at 122,894,827 bp
  • G to T, chromosome 10 at 7,867,938 bp
  • G to T, chromosome 10 at 22,067,256 bp
  • A to G, chromosome 10 at 23,961,014 bp
  • C to T, chromosome 10 at 103,189,987 bp
  • A to T, chromosome 11 at 100,354,715 bp
  • A to G, chromosome 13 at 12,188,157 bp
  • A to T, chromosome 13 at 58,564,198 bp
  • G to A, chromosome 13 at 97,098,801 bp
  • T to A, chromosome 15 at 9,085,782 bp
  • A to G, chromosome 17 at 25,491,901 bp
  • C to T, chromosome 17 at 69,274,091 bp
  • A to G, chromosome 18 at 34,445,262 bp
  • A to T, chromosome 18 at 89,246,983 bp
  • A to T, chromosome 19 at 10,606,973 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2354 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040336-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.