Strain Name:
C57BL/6J-MtgxR2355Btlr/Mmmh
Stock Number:
040337-MU
Citation ID:
RRID:MMRRC_040337-MU
Other Names:
R2355 (G1), C57BL/6J-MtgxR2355Btlr
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Cyn, Gena 52, Whi, Todo, Obt, WBE1, Mt, A730019I05Rik, Lda, Flo, GENA 47, Edy, GENA 60, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Epyc
Name: epiphycan
Synonyms: PG-Lb, Dspg3, epiphycan, SLRR3B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13516
HGNC: HGNC:3053
Homologene: 3634
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 2610510B01Rik, Dopey2, 0610038M01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Kcmf1
Name: potassium channel modulatory factor 1
Synonyms: 1700094M07Rik, clone DEBT-91, Pmcf
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74287
Homologene: 99845
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Ebag9
Name: estrogen receptor-binding fragment-associated gene 9
Synonyms: Rcas1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 55960
VEGA: 15
HGNC: HGNC:3123
Homologene: 3107
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 4632408O18Rik, Nibp, 1810044A24Rik, TRS130, 2900005P22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Myst2, Hboa, Hbo1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217127
Homologene: 5134
Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Synonyms: 4932418O06Rik, Grf2, C3G
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107746
HGNC: HGNC:4568
Homologene: 50501
Mettl25
Name: methyltransferase like 25
Synonyms: BC067068
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216292
Homologene: 32774
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: Ccdc132, 8430415E05Rik, 1700034M03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73288
Homologene: 11498
Plppr1
Name: phospholipid phosphatase related 1
Synonyms: E130309F12Rik, PRG-3, Lppr1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 272031
Homologene: 9815
Lmo7
Name: LIM domain only 7
Synonyms: FBXO20, LOC380928
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Cyp4a30-ps
Name: cytochrome P450, family 4, subfamily a, member 30, pseudogene
Synonyms: Gm12836
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 546842
Chst2
Name: carbohydrate sulfotransferase 2
Synonyms: C130041E03Rik, Gn6st, N-acetylglucosamine-6-O-sulfotransferase, GST-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54371
HGNC: HGNC:1970
Homologene: 3150
Alas1
Name: aminolevulinic acid synthase 1
Synonyms: Alas-1, succinyl-CoA: glycine C-succinyl transferase, 5-aminolevulinate synthase, ALAS-N
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11655
HGNC: HGNC:396
Homologene: 55478
M1ap
Name: meiosis 1 associated protein
Synonyms: D6Mm5e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110958
Homologene: 13210
Gps2
Name: G protein pathway suppressor 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56310
HGNC: HGNC:4550
Homologene: 49599
Ddx41
Name: DEAD box helicase 41
Synonyms: 2900024F02Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72935
VEGA: 13
Homologene: 9431
Rabgef1
Name: RAB guanine nucleotide exchange factor (GEF) 1
Synonyms: Ras negative regulator Rabex-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56715
Homologene: 8720
Ahcyl1
Name: S-adenosylhomocysteine hydrolase-like 1
Synonyms: DCAL, 1110034F20Rik, Ahcy-rs3, IRBIT
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229709
HGNC: HGNC:344
Homologene: 77353
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Or5d18
Name: olfactory receptor family 5 subfamily D member 18
Synonyms: GA_x6K02T2Q125-49527073-49526132, mOR-EG, MOR174-9, Olfr73
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 117004
Homologene: 133889
Pcdhb5
Name: protocadherin beta 5
Synonyms: Pcdhb4A, PcdhbE
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93876
HGNC: HGNC:8689
Homologene: 75103
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Abcb9
Name: ATP-binding cassette, sub-family B member 9
Synonyms: TAPL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56325
HGNC: HGNC:50
Homologene: 10491
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Or6c209
Name: olfactory receptor family 6 subfamily C member 209
Synonyms: Olfr799, MOR114-2, GA_x6K02T2PULF-11325750-11326685
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258929
Homologene: 37000
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Bbof1
Name: basal body orientation factor 1
Synonyms: Ccdc176, 2900006K08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72873
Homologene: 75215
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPSase I, CPS, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Vwa5b1
Name: von Willebrand factor A domain containing 5B1
Synonyms: 4931403E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75718
Homologene: 19431
Trim42
Name: tripartite motif-containing 42
Synonyms: 4930486B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78911
Homologene: 12712
Il12b
Name: interleukin 12b
Synonyms: Il-12p40, IL-12 p40, Il-12b, IL-23 subunit p40
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16160
HGNC: HGNC:5970
Homologene: 1648
Tectb
Name: tectorin beta
Synonyms: [b]-tectorin, Tctnb
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21684
Homologene: 7568
Fam171a1
Name: family with sequence similarity 171, member A1
Synonyms: 9630050M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269233
Homologene: 19521
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Ccdc149
Name: coiled-coil domain containing 149
Synonyms: LOC242997, Gm447
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503884
Homologene: 65264
Or56a5
Name: olfactory receptor family 56 subfamily A member 5
Synonyms: MOR40-1, Olfr683, GA_x6K02T2PBJ9-7773007-7772066
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259047
Homologene: 133645
Or5b24
Name: olfactory receptor family 5 subfamily B member 24
Synonyms: GA_x6K02T2RE5P-3264213-3265157, MOR202-34, Olfr1449
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258300
Homologene: 17184
Smg9
Name: SMG9 nonsense mediated mRNA decay factor
Synonyms: 1500002O20Rik, N28092, smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71997
Homologene: 10426
Amn
Name: amnionless
Synonyms: 5033428N14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 93835
VEGA: 12
Homologene: 12804
H2-DMb1
Name: histocompatibility 2, class II, locus Mb1
Synonyms: H-2Mb1, H2-Mb1, H2-M beta1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14999
HGNC: HGNC:4935
Homologene: 68231
Ceacam5
Name: CEA cell adhesion molecule 5
Synonyms: Psg30, 1600029H12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73250
HGNC: HGNC:1819
Homologene: 115938
Mapk8ip2
Name: mitogen-activated protein kinase 8 interacting protein 2
Synonyms: 3230402N03Rik, IB2, JNK-interacting protein, Jip2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 60597
HGNC: HGNC:6883
Homologene: 8201
Lmod1
Name: leiomodin 1 (smooth muscle)
Synonyms: 9530015K06Rik, D1, SM-Lmod, 1D, 64kD D1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93689
HGNC: HGNC:6647
Homologene: 8118
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Mfsd1
Name: major facilitator superfamily domain containing 1
Synonyms: 1200003O06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66868
Homologene: 11228
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: Lppr3, BC005764
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216152
Homologene: 11769
Or7g26
Name: olfactory receptor family 7 subfamily G member 26
Synonyms: GA_x6K02T2PVTD-13056760-13057689, MOR153-3, Olfr844
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100503048
HGNC: HGNC:8466
Ebpl
Name: emopamil binding protein-like
Synonyms: 5730442K12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68177
VEGA: 14
Homologene: 12243
Lmf2
Name: lipase maturation factor 2
Synonyms: Tmem112b, Tmem153
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105847
VEGA: 15
Homologene: 11251
Spr-ps1
Name: sepiapterin reductase pseudogene 1
Synonyms: Sprp, EG665089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 665089
Tnxa
Name: tenascin XA (pseudogene)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100043024
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,582,502 bp
  • C to T, chromosome 1 at 67,156,224 bp
  • T to A, chromosome 1 at 135,364,515 bp
  • C to T, chromosome 2 at 3,225,533 bp
  • T to C, chromosome 2 at 29,700,653 bp
  • T to A, chromosome 2 at 88,035,035 bp
  • T to A, chromosome 3 at 67,601,335 bp
  • A to G, chromosome 3 at 107,670,217 bp
  • G to T, chromosome 4 at 8,801,350 bp
  • T to A, chromosome 4 at 49,282,249 bp
  • C to A, chromosome 4 at 115,344,261 bp
  • C to A, chromosome 4 at 138,591,910 bp
  • T to C, chromosome 5 at 52,420,772 bp
  • CGG to CG, chromosome 5 at 124,077,305 bp
  • C to T, chromosome 5 at 130,212,087 bp
  • A to T, chromosome 5 at 146,099,812 bp
  • T to A, chromosome 6 at 3,536,976 bp
  • A to T, chromosome 6 at 72,850,483 bp
  • C to A, chromosome 6 at 73,156,421 bp
  • G to A, chromosome 6 at 82,956,503 bp
  • A to G, chromosome 6 at 85,155,721 bp
  • T to A, chromosome 7 at 17,745,635 bp
  • G to A, chromosome 7 at 24,420,121 bp
  • A to T, chromosome 7 at 105,143,813 bp
  • A to G, chromosome 7 at 144,057,718 bp
  • A to G, chromosome 9 at 19,318,744 bp
  • A to G, chromosome 9 at 95,406,095 bp
  • A to T, chromosome 9 at 97,359,240 bp
  • A to G, chromosome 9 at 106,236,474 bp
  • A to G, chromosome 9 at 118,560,742 bp
  • C to T, chromosome 10 at 79,865,360 bp
  • A to G, chromosome 10 at 97,677,013 bp
  • C to A, chromosome 10 at 105,763,455 bp
  • A to T, chromosome 10 at 107,808,788 bp
  • G to A, chromosome 10 at 129,647,842 bp
  • A to G, chromosome 11 at 44,410,212 bp
  • AGTGCT to A, chromosome 11 at 69,915,381 bp
  • T to C, chromosome 11 at 85,005,909 bp
  • A to C, chromosome 11 at 95,291,581 bp
  • T to C, chromosome 12 at 11,457,108 bp
  • A to G, chromosome 12 at 84,423,449 bp
  • C to A, chromosome 12 at 111,271,812 bp
  • T to G, chromosome 13 at 55,534,300 bp
  • A to G, chromosome 14 at 44,336,461 bp
  • A to T, chromosome 14 at 61,347,453 bp
  • A to G, chromosome 14 at 101,888,685 bp
  • T to C, chromosome 15 at 44,627,649 bp
  • CCTTTGCGCTT to CCTT, chromosome 15 at 47,741,236 bp
  • A to T, chromosome 15 at 72,952,960 bp
  • A to T, chromosome 15 at 89,351,763 bp
  • G to T, chromosome 15 at 89,458,965 bp
  • A to G, chromosome 16 at 5,094,497 bp
  • G to A, chromosome 16 at 93,770,677 bp
  • A to G, chromosome 17 at 34,157,315 bp
  • A to G, chromosome 17 at 34,800,364 bp
  • T to A, chromosome 18 at 37,322,116 bp
  • T to C, chromosome 19 at 12,935,019 bp
  • C to G, chromosome 19 at 55,180,999 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2355 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040337-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.