Strain Name:
C57BL/6J-MtgxR2358Btlr/Mmmh
Stock Number:
040340-MU
Citation ID:
RRID:MMRRC_040340-MU
Other Names:
R2358 (G1), C57BL/6J-MtgxR2358Btlr
Major Collection:

Gene Information

Pi4k2a
Name: phosphatidylinositol 4-kinase type 2 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 84095
VEGA: 19
Homologene: 101681
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94187
Homologene: 9010
Fzr1
Name: fizzy and cell division cycle 20 related 1
Synonyms: Fyr, Cdh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56371
Homologene: 9444
Mta3
Name: metastasis associated 3
Synonyms: 1110002J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 116871
Homologene: 14282
Denn2b
Name: DENN domain containing 2B
Synonyms: 2610305K15Rik, 2010004M01Rik, St5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76954
Homologene: 3951
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: P19-PTP, PTP-PEST, PTP-P19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Rbm27
Name: RNA binding motif protein 27
Synonyms: Psc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225432
VEGA: 18
Homologene: 35410
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4-2, 1300012C07Rik, Nedd4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Dcaf13
Name: DDB1 and CUL4 associated factor 13
Synonyms: LOC223499, Wdsof1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223499
Homologene: 6430
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Sdhb
Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Synonyms: 0710008N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67680
Homologene: 2255
Sun2
Name: Sad1 and UNC84 domain containing 2
Synonyms: B230369L08Rik, Unc84b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223697
Homologene: 9113
Rad51
Name: RAD51 recombinase
Synonyms: Reca, Rad51a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19361
HGNC: HGNC:9817
Homologene: 2155
Themis
Name: thymocyte selection associated
Synonyms: E430004N04Rik, Gasp, Tsepa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210757
Homologene: 72287
Cyp4a30-ps
Name: cytochrome P450, family 4, subfamily a, member 30, pseudogene
Synonyms: Gm12836
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 546842
Jaml
Name: junction adhesion molecule like
Synonyms: LOC270152, Amica1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270152
Homologene: 17708
Fcrl5
Name: Fc receptor-like 5
Synonyms: BXMAS1-like protein 2, Fcrh3, mBXMH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329693
Homologene: 137404
Il17rb
Name: interleukin 17 receptor B
Synonyms: Evi27, IL-17ER, IL17RH1, IL-17Rh1, Il17br
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50905
Homologene: 10287
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: 2310047C21Rik, D8Wsu49e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71927
Homologene: 12423
Copg2
Name: coatomer protein complex, subunit gamma 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54160
HGNC: HGNC:2237
Homologene: 56292
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104401
Homologene: 17000
Zcrb1
Name: zinc finger CCHC-type and RNA binding motif 1
Synonyms: 2700088M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67197
Homologene: 12095
Mrnip
Name: MRN complex interacting protein
Synonyms: 3010026O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68067
Homologene: 75241
Siglecg
Name: sialic acid binding Ig-like lectin G
Synonyms: mSiglec-G, A630096C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243958
Homologene: 13228
Aif1l
Name: allograft inflammatory factor 1-like
Synonyms: 2810003C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108897
Homologene: 12863
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: Nalp-eta, E330028A19Rik, Nalp4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243880
Homologene: 79696
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: IL-12RB2, Ifnm, A930027I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Efcab7
Name: EF-hand calcium binding domain 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230500
Homologene: 19952
Fer1l4
Name: fer-1-like 4 (C. elegans)
Synonyms: 9130402C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74562
Homologene: 19075
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Abcb9
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 9
Synonyms: TAPL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56325
HGNC: HGNC:50
Homologene: 10491
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210876
Homologene: 86604
Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Synonyms: 2700043D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 108037
VEGA: 10
Homologene: 133984
Ripor3
Name: RIPOR family member 3
Synonyms: 2310033K02Rik, Fam65c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69553
Homologene: 15438
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Zyg11a
Name: zyg-11 family member A, cell cycle regulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230590
Homologene: 66294
Olfr121
Name: olfactory receptor 121
Synonyms: GA_x6K02T2PSCP-2211113-2212078, MOR263-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258622
Homologene: 17195
Vsig10l
Name: V-set and immunoglobulin domain containing 10 like
Synonyms: 2210412E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75690
Homologene: 35386
Wt1
Name: WT1 transcription factor
Synonyms: Wt-1, D630046I19Rik, Wilms tumor 1 homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22431
Homologene: 11536
Tectb
Name: tectorin beta
Synonyms: [b]-tectorin, Tctnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21684
Homologene: 7568
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf-13b, Cf13b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Slc6a15
Name: solute carrier family 6 (neurotransmitter transporter), member 15
Synonyms: v7-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103098
VEGA: 10
Homologene: 18163
Gm20605
Name: predicted gene 20605
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100316903
Itgav
Name: integrin alpha V
Synonyms: vitronectin receptor alpha polypeptide (VNRA), CD51, alphav-integrin, 1110004F14Rik, 2610028E01Rik, D430040G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Strip1
Name: striatin interacting protein 1
Synonyms: 6530401O14Rik, 6330569M22Rik, Fam40a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229707
Homologene: 35064
Ankzf1
Name: ankyrin repeat and zinc finger domain containing 1
Synonyms: 1300008P06Rik, 2810025E10Rik, D1Ertd161e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 52231
Homologene: 41225
Smtn
Name: smoothelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 29856
Homologene: 8482
Fam75d3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Lrfn2
Name: leucine rich repeat and fibronectin type III domain containing 2
Synonyms: 5730420O05Rik, SALM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70530
Homologene: 19182
Kif28
Name: kinesin family member 28
Synonyms: LOC383592, Gm1305
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 383592
Homologene: 130945
Tmem14a
Name: transmembrane protein 14A
Synonyms: PTD011, 5730496E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75712
Homologene: 36341
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244199
Homologene: 18255
Zfy2
Name: zinc finger protein 2, Y-linked
Synonyms: Zfy-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22768
Homologene: 56456
Terb2
Name: telomere repeat binding bouquet formation protein 2
Synonyms: 4933406J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74401
Homologene: 17583
Apol7a
Name: apolipoprotein L 7a
Synonyms: 9130022K13Rik, Apol3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75761
Homologene: 40940
Spopl
Name: speckle-type BTB/POZ protein-like
Synonyms: E430033K04Rik, 4921517N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76857
Homologene: 78016
Vmn1r205
Name: vomeronasal 1 receptor 205
Synonyms: V1rh8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171251
Homologene: 110880
Olfr74
Name: olfactory receptor 74
Synonyms: mOR-EV, MOR174-4, GA_x6K02T2Q125-49458388-49457432
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 117005
Homologene: 74078
Rpl13-ps3
Name: ribosomal protein L13, pseudogene 3
Synonyms: Gm9026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 668182
VEGA: 14
Olfr1351
Name: olfactory receptor 1351
Synonyms: GA_x6K02T2QGN0-2794907-2793948, MOR139-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 259042
Homologene: 133668
Mrpl32
Name: mitochondrial ribosomal protein L32
Synonyms: 0610033O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75398
VEGA: 13
Homologene: 32711
Cd27
Name: CD27 antigen
Synonyms: Cd27, S152, Tp55, Tnfrsf7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21940
Homologene: 74386
Sap18b
Name: Sin3-associated polypeptide 18B
Synonyms: Gm10094
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100041953
Homologene: 4289
Cela1
Name: chymotrypsin-like elastase family, member 1
Synonyms: PC-TsF, Ela-1, 1810009A17Rik, 1810062B19Rik, Ela1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109901
VEGA: 15
HGNC: HGNC:3308
Homologene: 20454
Spopfm2
Name: speckle-type BTB/POZ protein family member 2
Synonyms: Gm10696
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100043188
Homologene: 128308
Tlnrd1
Name: talin rod domain containing 1
Synonyms: Mesdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80889
Homologene: 11209
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 21,226,054 bp
  • C to T, chromosome 1 at 75,195,251 bp
  • A to T, chromosome 1 at 139,501,818 bp
  • A to T, chromosome 1 at 179,709,459 bp
  • C to T, chromosome 2 at 23,537,380 bp
  • T to A, chromosome 2 at 31,969,751 bp
  • T to A, chromosome 2 at 83,779,070 bp
  • A to T, chromosome 2 at 87,973,722 bp
  • T to A, chromosome 2 at 91,501,954 bp
  • G to A, chromosome 2 at 105,163,428 bp
  • T to A, chromosome 2 at 119,134,518 bp
  • T to A, chromosome 2 at 122,198,432 bp
  • G to A, chromosome 2 at 156,044,429 bp
  • A to G, chromosome 2 at 167,983,865 bp
  • A to G, chromosome 3 at 87,446,419 bp
  • G to A, chromosome 3 at 94,175,547 bp
  • C to A, chromosome 3 at 94,175,548 bp
  • A to G, chromosome 3 at 107,615,819 bp
  • T to A, chromosome 4 at 99,831,586 bp
  • G to T, chromosome 4 at 108,196,146 bp
  • C to A, chromosome 4 at 115,344,261 bp
  • T to C, chromosome 4 at 140,973,000 bp
  • G to A, chromosome 5 at 20,998,692 bp
  • CGG to CG, chromosome 5 at 124,077,305 bp
  • A to G, chromosome 5 at 137,638,548 bp
  • A to T, chromosome 6 at 30,826,233 bp
  • C to T, chromosome 6 at 67,298,195 bp
  • A to G, chromosome 6 at 125,233,318 bp
  • A to G, chromosome 7 at 26,464,198 bp
  • A to G, chromosome 7 at 43,409,422 bp
  • G to A, chromosome 7 at 43,468,761 bp
  • A to T, chromosome 7 at 83,882,280 bp
  • A to T, chromosome 7 at 107,794,915 bp
  • A to T, chromosome 7 at 109,556,446 bp
  • A to T, chromosome 7 at 130,516,165 bp
  • G to A, chromosome 8 at 15,112,018 bp
  • C to A, chromosome 8 at 85,738,129 bp
  • G to T, chromosome 8 at 87,780,551 bp
  • G to A, chromosome 8 at 95,825,563 bp
  • A to C, chromosome 9 at 45,101,063 bp
  • T to A, chromosome 10 at 28,863,380 bp
  • T to C, chromosome 10 at 79,018,188 bp
  • C to T, chromosome 10 at 81,367,640 bp
  • T to G, chromosome 10 at 103,416,785 bp
  • T to C, chromosome 10 at 127,518,028 bp
  • A to T, chromosome 11 at 3,532,865 bp
  • T to C, chromosome 11 at 50,182,590 bp
  • A to T, chromosome 13 at 14,610,580 bp
  • T to A, chromosome 13 at 22,592,396 bp
  • G to A, chromosome 13 at 59,703,888 bp
  • A to G, chromosome 14 at 30,004,257 bp
  • A to G, chromosome 14 at 58,893,816 bp
  • A to G, chromosome 15 at 39,145,267 bp
  • G to A, chromosome 15 at 77,393,545 bp
  • A to G, chromosome 15 at 79,727,913 bp
  • A to T, chromosome 15 at 93,395,628 bp
  • A to G, chromosome 15 at 100,681,228 bp
  • T to A, chromosome 17 at 22,568,830 bp
  • T to A, chromosome 17 at 37,752,380 bp
  • A to G, chromosome 17 at 49,071,160 bp
  • A to G, chromosome 17 at 83,762,988 bp
  • T to C, chromosome 18 at 42,292,112 bp
  • G to A, chromosome 18 at 65,209,719 bp
  • G to A, chromosome 19 at 5,683,339 bp
  • C to G, chromosome 19 at 5,683,340 bp
  • G to A, chromosome 19 at 42,090,692 bp
  • C to G, chromosome 19 at 55,180,999 bp
  • T to C, chromosome Y at 2,107,272 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2358 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040340-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.