Strain Name:
C57BL/6J-MtgxR2359Btlr/Mmmh
Stock Number:
040341-MU
Citation ID:
RRID:MMRRC_040341-MU
Other Names:
R2359 (G1), C57BL/6J-MtgxR2359Btlr
Major Collection:

Gene Information

Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Gabrg1
Name: gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 5033417D07Rik, 34kDa, D5Ertd679e, BTF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99371
Homologene: 111880
Chtf8
Name: CTF8, chromosome transmission fidelity factor 8
Synonyms: 5830457O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 214987
Homologene: 84588
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: Hsp90, Hsp89, Hsp86-1, hsp4, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Rab30
Name: RAB30, member RAS oncogene family
Synonyms: 5033421K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75985
HGNC: HGNC:9770
Homologene: 22815
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Larp4b
Name: La ribonucleoprotein domain family, member 4B
Synonyms: Larp5, D13Wsu64e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 217980
Homologene: 18195
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213895
Homologene: 7065
Golph3l
Name: golgi phosphoprotein 3-like
Synonyms: 2010204I15Rik, GPP34R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229593
Homologene: 23082
Arid2
Name: AT rich interactive domain 2 (ARID, RFX-like)
Synonyms: 1700124K17Rik, zipzap/p200, 4432409D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77044
Homologene: 14601
Epha8
Name: Eph receptor A8
Synonyms: Hek3, EphA8, Eek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Ipo8
Name: importin 8
Synonyms: Om1, 6230418K12Rik, C130009K11Rik, Ranbp8, OM-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CAP-D2, CNAP1, 2810465G24Rik, 2810406C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68298
Homologene: 6497
Smarcd2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Synonyms: Baf60b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83796
Homologene: 20671
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: 2610301F02Rik, ENSMUSG00000075261, CAMDI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545428
Homologene: 52149
Csf2rb2
Name: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
Synonyms: AIC2A, BetaIl3, Bil3, Il3r, Il3rb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12984
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Ntn1
Name: netrin 1
Synonyms: Netrin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18208
HGNC: HGNC:8029
Homologene: 21008
Med13
Name: mediator complex subunit 13
Synonyms: 1110067M05Rik, Trap240, Thrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327987
Homologene: 21067
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, 1110059H15Rik, Zfp650, A130030D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Cep63
Name: centrosomal protein 63
Synonyms: D9Mgc41, CD20R, ET2, D9Mgc48e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 28135
Homologene: 11861
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 386750
Homologene: 8955
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, 4930516E05Rik, D330038K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Prss22
Name: protease, serine 22
Synonyms: 4733401N09Rik, SP001LA, BSSP-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70835
VEGA: 17
Homologene: 23344
Tmprss4
Name: transmembrane protease, serine 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214523
Homologene: 80930
Anxa9
Name: annexin A9
Synonyms: 2310069F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71790
HGNC: HGNC:547
Homologene: 2643
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Efr3b
Name: EFR3 homolog B
Synonyms: C030014M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668212
VEGA: 12
Homologene: 66195
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 105242472
Ggt6
Name: gamma-glutamyltransferase 6
Synonyms: 9030405D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71522
Homologene: 51918
Vmn1r22
Name: vomeronasal 1 receptor 22
Synonyms: V1rc23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171196
Homologene: 110825
Igbp1b
Name: immunoglobulin (CD79A) binding protein 1b
Synonyms: alpha4-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50540
Homologene: 75049
Akr1c20
Name: aldo-keto reductase family 1, member C20
Synonyms: 2610528B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 116852
Snx14
Name: sorting nexin 14
Synonyms: C330035N22Rik, YR-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244962
Homologene: 17823
Adam24
Name: a disintegrin and metallopeptidase domain 24 (testase 1)
Synonyms: Dtgn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Cyp2c40
Name: cytochrome P450, family 2, subfamily c, polypeptide 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13099
Homologene: 74936
Nosip
Name: nitric oxide synthase interacting protein
Synonyms: CGI-25, 2310061K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66394
Homologene: 9315
Polrmt
Name: polymerase (RNA) mitochondrial (DNA directed)
Synonyms: 1110018N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216151
HGNC: HGNC:9200
Homologene: 37996
3830406C13Rik
Name: RIKEN cDNA 3830406C13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218734
VEGA: 14
Homologene: 10787
Alkbh3
Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
Synonyms: mABH3, Abh3, 1810020C19Rik, 1700108H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69113
Homologene: 16393
Neurl1b
Name: neuralized E3 ubiquitin protein ligase 1B
Synonyms: Neur2, EG240055, C230078M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240055
Homologene: 35443
Cd55b
Name: CD55 molecule, decay accelerating factor for complement B
Synonyms: complement-transmembrane, TM-DAF, Daf-TM, Daf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13137
HGNC: HGNC:2665
Homologene: 479
Hyi
Name: hydroxypyruvate isomerase (putative)
Synonyms: 2700033B16Rik, 6430559E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68180
Rwdd2b
Name: RWD domain containing 2B
Synonyms: ORF5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 53858
HGNC: HGNC:1302
Homologene: 9654
Prxl2c
Name: peroxiredoxin like 2C
Synonyms: 1110018J18Rik, Aaed1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66129
VEGA: 13
Homologene: 7192
Gm4204
Name: predicted gene 4204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100043064
Cyp2j15-ps
Name: cytochrome P450, family 2, subfamily j, member 15, pseudogene
Synonyms: Gm12658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100125600
Fbxo48
Name: F-box protein 48
Synonyms: A630050E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319701
Homologene: 18541
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 130,418,121 bp
  • T to A, chromosome 1 at 135,232,189 bp
  • C to A, chromosome 2 at 69,922,236 bp
  • C to T, chromosome 2 at 77,170,402 bp
  • T to C, chromosome 2 at 94,008,113 bp
  • A to T, chromosome 2 at 166,860,619 bp
  • T to G, chromosome 3 at 73,049,345 bp
  • T to C, chromosome 3 at 86,348,750 bp
  • A to C, chromosome 3 at 95,302,751 bp
  • A to G, chromosome 3 at 95,591,964 bp
  • T to A, chromosome 3 at 144,925,242 bp
  • T to C, chromosome 4 at 96,273,603 bp
  • A to G, chromosome 4 at 118,360,341 bp
  • A to G, chromosome 4 at 136,946,032 bp
  • A to G, chromosome 5 at 70,778,047 bp
  • A to G, chromosome 5 at 124,590,876 bp
  • A to T, chromosome 6 at 57,900,989 bp
  • G to A, chromosome 6 at 118,417,376 bp
  • A to G, chromosome 6 at 125,179,416 bp
  • G to A, chromosome 6 at 138,657,715 bp
  • G to A, chromosome 6 at 148,816,477 bp
  • G to A, chromosome 7 at 45,074,026 bp
  • A to G, chromosome 7 at 92,835,797 bp
  • A to G, chromosome 8 at 40,680,945 bp
  • G to T, chromosome 8 at 106,885,416 bp
  • A to G, chromosome 9 at 45,185,832 bp
  • T to G, chromosome 9 at 88,384,024 bp
  • A to C, chromosome 9 at 102,594,564 bp
  • A to T, chromosome 10 at 79,736,562 bp
  • G to A, chromosome 11 at 16,953,602 bp
  • G to A, chromosome 11 at 68,385,612 bp
  • A to T, chromosome 11 at 72,437,551 bp
  • C to T, chromosome 11 at 86,291,035 bp
  • T to C, chromosome 11 at 104,739,280 bp
  • T to C, chromosome 11 at 106,267,164 bp
  • T to C, chromosome 12 at 3,901,599 bp
  • G to A, chromosome 12 at 3,980,136 bp
  • A to G, chromosome 12 at 110,694,569 bp
  • C to T, chromosome 13 at 4,523,277 bp
  • C to A, chromosome 13 at 9,158,163 bp
  • A to G, chromosome 13 at 55,213,711 bp
  • A to T, chromosome 13 at 64,312,651 bp
  • T to A, chromosome 14 at 12,297,572 bp
  • A to G, chromosome 15 at 76,597,673 bp
  • C to T, chromosome 15 at 78,292,776 bp
  • G to T, chromosome 15 at 96,361,878 bp
  • C to T, chromosome 16 at 87,436,921 bp
  • A to C, chromosome 17 at 23,994,584 bp
  • T to C, chromosome 17 at 26,441,595 bp
  • A to G, chromosome 19 at 16,652,679 bp
  • A to T, chromosome 19 at 39,777,954 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2359 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040341-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.