Strain Name:
C57BL/6J-MtgxR2360Btlr/Mmmh
Stock Number:
040342-MU
Citation ID:
RRID:MMRRC_040342-MU
Other Names:
R2360 (G1), C57BL/6J-MtgxR2360Btlr
Major Collection:

Strain Information

Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Cdc42ep4
Name: CDC42 effector protein 4
Synonyms: 1500041M20Rik, Borg4, CEP4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56699
Homologene: 8110
Nr5a2
Name: nuclear receptor subfamily 5, group A, member 2
Synonyms: UF2-H3B, Ftf, D1Ertd308e, LRH-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26424
HGNC: HGNC:7984
Homologene: 20827
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: Fthfsdc1, 2410004L15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Morc3
Name: microrchidia 3
Synonyms: D16Jhu32e, 1110051N18Rik, 1110051N18Rik, Zcwcc3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: CGI-72, E130113K22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
Sbno2
Name: strawberry notch 2
Synonyms: Stno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216161
VEGA: 10
Homologene: 8981
Traf3ip1
Name: TRAF3 interacting protein 1
Synonyms: 3930402D05Rik, MIP-T3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74019
Homologene: 22913
Resf1
Name: retroelement silencing factor 1
Synonyms: GET, 2810474O19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67246
Homologene: 19251
Med25
Name: mediator complex subunit 25
Synonyms: ESTM2, 2610529E18Rik, 2610034E13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75613
Homologene: 12614
Slc39a3
Name: solute carrier family 39 (zinc transporter), member 3
Synonyms: zip3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 106947
Homologene: 44230
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: C330027C09Rik, Cip2a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224171
Homologene: 10842
Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Synonyms: Dat1, DAT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13162
VEGA: 13
Homologene: 55547
Crtam
Name: cytotoxic and regulatory T cell molecule
Synonyms: class I-restricted T cell-associated molecule
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54698
Homologene: 10454
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: Min, adenomatosis polyposis coli, CC1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
Synonyms: Lbcl1, GEF-H1, LFP40, Lfc, GEFH1, P40
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16800
HGNC: HGNC:682
Homologene: 3468
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Map3k7
Name: mitogen-activated protein kinase kinase kinase 7
Synonyms: TGF-beta activated kinase 1, Tak1, transforming growth factor-beta-activated kinase 1, TAK1, transforming growth factor beta-activated kinase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26409
HGNC: HGNC:6859
Homologene: 118818
Zfp984
Name: zinc finger protein 984
Synonyms: Gm13157
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041677
Homologene: 133076
Morn1
Name: MORN repeat containing 1
Synonyms: 2900057D20Rik, 4930417P05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76866
Homologene: 11757
4930432E11Rik
Name: RIKEN cDNA 4930432E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243900
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 2900024E21Rik, 3526401J03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Abca5
Name: ATP-binding cassette, sub-family A member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 4930539G24Rik, 1700110B15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Cpn2
Name: carboxypeptidase N, polypeptide 2
Synonyms: 1300018K11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71756
VEGA: 16
HGNC: HGNC:2313
Homologene: 19487
Mex3b
Name: mex3 RNA binding family member B
Synonyms: 4931439A04Rik, Rkhd3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108797
Homologene: 13570
Cyp3a41b
Name: cytochrome P450, family 3, subfamily a, polypeptide 41B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041375
HGNC: HGNC:2638
Homologene: 133568
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625131
Homologene: 129606
Setd4
Name: SET domain containing 4
Synonyms: ORF21
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224440
HGNC: HGNC:1258
Homologene: 41173
Vmn1r209
Name: vomeronasal 1 receptor 209
Synonyms: Gm11315
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432736
Homologene: 110880
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Ccdc70
Name: coiled-coil domain containing 70
Synonyms: 1700112P19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67929
Homologene: 12214
Napa
Name: N-ethylmaleimide sensitive fusion protein attachment protein alpha
Synonyms: RA81, SNARE, SNAPA, 1500039N14Rik, hyh, a-SNAP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108124
HGNC: HGNC:7641
Homologene: 2839
Sh2d4b
Name: SH2 domain containing 4B
Synonyms: A430109M18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328381
Homologene: 19164
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: Spi-2, RP54, 1300001I07Rik, MMSpi2, MMCM2, alpha-1 antiproteinase, Spi2, D12Rp54, contrapsin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
Rfk
Name: riboflavin kinase
Synonyms: flavokinase, 0610038L10Rik, ATP:riboflavin 5'-phosphotransferase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54391
Homologene: 115690
Zfp768
Name: zinc finger protein 768
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233890
Homologene: 11650
Or14j6
Name: olfactory receptor family 14 subfamily J member 6
Synonyms: GA_x6K02T2PSCP-2354126-2355093, MOR218-7, Olfr127
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258374
Homologene: 134080
Atp6v1g2
Name: ATPase, H+ transporting, lysosomal V1 subunit G2
Synonyms: 1500002D01Rik, VAG2, Atp6g2, NG38, lysosomal 13kDa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66237
HGNC: HGNC:862
Homologene: 41518
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 91,499,652 bp
  • T to C, chromosome 1 at 136,948,827 bp
  • A to G, chromosome 2 at 77,927,247 bp
  • T to A, chromosome 3 at 88,634,416 bp
  • T to C, chromosome 4 at 31,964,302 bp
  • A to G, chromosome 4 at 147,754,777 bp
  • T to A, chromosome 4 at 155,092,313 bp
  • T to C, chromosome 5 at 137,396,126 bp
  • T to C, chromosome 5 at 145,570,411 bp
  • A to G, chromosome 6 at 149,334,647 bp
  • A to G, chromosome 7 at 16,114,158 bp
  • A to T, chromosome 7 at 29,574,789 bp
  • A to G, chromosome 7 at 44,885,142 bp
  • T to C, chromosome 7 at 82,867,862 bp
  • A to G, chromosome 7 at 120,251,208 bp
  • T to C, chromosome 7 at 127,344,638 bp
  • A to G, chromosome 8 at 21,973,431 bp
  • A to G, chromosome 8 at 64,051,401 bp
  • A to G, chromosome 9 at 40,973,515 bp
  • G to T, chromosome 10 at 4,056,771 bp
  • G to A, chromosome 10 at 78,812,884 bp
  • T to C, chromosome 10 at 80,058,021 bp
  • A to T, chromosome 10 at 81,031,270 bp
  • G to T, chromosome 10 at 130,479,762 bp
  • T to A, chromosome 11 at 110,289,777 bp
  • A to G, chromosome 11 at 113,728,702 bp
  • A to G, chromosome 12 at 81,950,186 bp
  • C to T, chromosome 12 at 104,340,907 bp
  • T to A, chromosome 13 at 22,805,666 bp
  • T to A, chromosome 13 at 73,569,977 bp
  • C to T, chromosome 14 at 40,860,591 bp
  • G to A, chromosome 15 at 66,594,920 bp
  • T to C, chromosome 16 at 30,259,503 bp
  • C to T, chromosome 16 at 49,017,465 bp
  • T to C, chromosome 16 at 93,586,234 bp
  • T to C, chromosome 16 at 93,841,387 bp
  • A to T, chromosome 17 at 30,677,204 bp
  • A to G, chromosome 17 at 35,237,662 bp
  • A to G, chromosome 17 at 37,904,454 bp
  • C to T, chromosome 18 at 34,261,126 bp
  • A to G, chromosome 19 at 17,398,596 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2360 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040342-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.