Strain Name:
C57BL/6J-MtgxR2384Btlr/Mmmh
Stock Number:
040358-MU
Citation ID:
RRID:MMRRC_040358-MU
Other Names:
R2384 (G1), C57BL/6J-MtgxR2384Btlr
Major Collection:

Gene Information

Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Uso1
Name: USO1 vesicle docking factor
Synonyms: Vdp, transcytosis associated protein p115, TAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56041
Homologene: 2754
Ucp2
Name: uncoupling protein 2 (mitochondrial, proton carrier)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22228
Homologene: 2516
Hsd17b12
Name: hydroxysteroid (17-beta) dehydrogenase 12
Synonyms: 2610510O05Rik, keratoadhesin, keratonectin, KIK-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56348
Homologene: 95094
Scg3
Name: secretogranin III
Synonyms: Chgd, SgIII, 1B1075
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20255
VEGA: 9
Homologene: 7526
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: 2700059D02Rik, nucling
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Cul3
Name: cullin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26554
HGNC: HGNC:2553
Homologene: 2661
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208727
Homologene: 55946
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: 2210412K19Rik, d1401, alpha-ketoglutarate dehydrogenase, 2210403E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Ints12
Name: integrator complex subunit 12
Synonyms: 4930529N21Rik, 1110020M19Rik, A230056J18Rik, 2810027J24Rik, Phf22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71793
Homologene: 32474
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rip1, Rinp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19766
Homologene: 2820
Slc41a3
Name: solute carrier family 41, member 3
Synonyms: SLC41A1-L2, 1010001P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71699
Homologene: 23052
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: B230339E18Rik, 1110014O20Rik, Stank
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15258
Homologene: 68766
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Ppil4
Name: peptidylprolyl isomerase (cyclophilin)-like 4
Synonyms: 3830425H19Rik, 3732410E19Rik, PPIase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67418
Homologene: 12126
Cnp
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
Synonyms: Cnp1, Cnp-1, CNPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12799
HGNC: HGNC:2158
Homologene: 7672
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74241
Homologene: 11574
Il1f9
Name: interleukin 1 family, member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215257
Homologene: 49595
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Podn
Name: podocan
Synonyms: SLRR5A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242608
Homologene: 17803
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Trim26
Name: tripartite motif-containing 26
Synonyms: Zfp173
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22670
Homologene: 31159
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: TRPP8, Trp-p8, CMR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 171382
Homologene: 23433
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: Gprc1e, 6430542K11Rik, mGluR5, Glu5R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Gm9839
Name: predicted gene 9839
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 408192
Homologene: 130042
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: TPRBK, 2310015L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209683
Homologene: 41023
Mup5
Name: major urinary protein 5
Synonyms: Mup V
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17844
Homologene: 74304
Adamdec1
Name: ADAM-like, decysin 1
Synonyms: Dcsn, 2210414L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 58860
VEGA: 14
Homologene: 8711
Ppp1r32
Name: protein phosphatase 1, regulatory subunit 32
Synonyms: 4930579J09Rik, IIIG9S, IIIG9, IIIG9L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Fscn2
Name: fascin actin-bundling protein 2
Synonyms: C630046B20Rik, ahl8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238021
HGNC: HGNC:3960
Homologene: 22722
Dnajb13
Name: DnaJ heat shock protein family (Hsp40) member B13
Synonyms: 1700014P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69387
Homologene: 70141
Tmem232
Name: transmembrane protein 232
Synonyms: LOC381107, E130009J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
Sele
Name: selectin, endothelial cell
Synonyms: E-selectin, CD62E, Elam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20339
Homologene: 389
Tmem161a
Name: transmembrane protein 161A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234371
Homologene: 9853
Nlrp4g
Name: NLR family, pyrin domain containing 4G
Synonyms: nalp4g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235779
VEGA: 9
Klrh1
Name: killer cell lectin-like receptor subfamily H, member 1
Synonyms: Gm156, LOC232415
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232415
Homologene: 16395
BC007180
Name: cDNA sequence BC007180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
4933414I15Rik
Name: RIKEN cDNA 4933414I15 gene
Synonyms: ENSMUSG00000051192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74408
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 32,519,895 bp
  • C to T, chromosome 1 at 75,475,109 bp
  • A to T, chromosome 1 at 80,283,689 bp
  • A to G, chromosome 1 at 88,359,656 bp
  • T to C, chromosome 1 at 91,984,485 bp
  • A to G, chromosome 1 at 164,050,775 bp
  • A to G, chromosome 2 at 24,192,648 bp
  • T to A, chromosome 2 at 94,033,619 bp
  • T to A, chromosome 3 at 133,109,103 bp
  • A to T, chromosome 3 at 154,764,651 bp
  • T to A, chromosome 4 at 61,835,024 bp
  • T to C, chromosome 4 at 108,022,072 bp
  • T to C, chromosome 5 at 92,152,539 bp
  • T to A, chromosome 5 at 111,276,208 bp
  • A to G, chromosome 6 at 38,818,371 bp
  • A to G, chromosome 6 at 90,626,411 bp
  • T to A, chromosome 6 at 129,772,380 bp
  • A to G, chromosome 7 at 87,602,728 bp
  • A to G, chromosome 7 at 100,498,254 bp
  • G to A, chromosome 7 at 100,507,363 bp
  • T to C, chromosome 8 at 70,177,554 bp
  • G to A, chromosome 9 at 60,869,917 bp
  • T to C, chromosome 9 at 75,665,726 bp
  • A to G, chromosome 9 at 124,349,707 bp
  • G to A, chromosome 10 at 7,797,743 bp
  • C to A, chromosome 11 at 6,342,526 bp
  • T to C, chromosome 11 at 9,267,450 bp
  • A to G, chromosome 11 at 50,942,506 bp
  • A to G, chromosome 11 at 59,042,837 bp
  • T to A, chromosome 11 at 72,858,394 bp
  • A to G, chromosome 11 at 100,576,453 bp
  • T to C, chromosome 11 at 120,366,733 bp
  • A to G, chromosome 12 at 3,901,591 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • A to G, chromosome 13 at 34,030,043 bp
  • A to C, chromosome 14 at 68,565,613 bp
  • C to T, chromosome 17 at 30,973,683 bp
  • C to T, chromosome 17 at 36,850,889 bp
  • G to A, chromosome 17 at 65,402,857 bp
  • T to A, chromosome 18 at 77,955,893 bp
  • A to C, chromosome 19 at 10,481,282 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2384 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040358-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.