Strain Name:
C57BL/6J-MtgxR2393Btlr/Mmmh
Stock Number:
040361-MU
Citation ID:
RRID:MMRRC_040361-MU
Other Names:
R2393 (G1), C57BL/6J-MtgxR2393Btlr
Major Collection:

Gene Information

Lhx6
Name: LIM homeobox protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16874
Homologene: 7401
Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Synonyms: Acra7, alpha7, alpha7 nicotinic receptor, alpha7-nAChR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11441
Homologene: 593
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Ndrg4
Name: N-myc downstream regulated gene 4
Synonyms: D8Bwg1337e, Ndr1-rs, SMAP-8, Ndr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234593
Homologene: 23228
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108096
Homologene: 56603
Ctbp2
Name: C-terminal binding protein 2
Synonyms: D7Ertd45e, Ribeye, Gtrgeo6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77683
Homologene: 11698
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hsp90, Hsp86-1, Hsp89, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Srgap2
Name: SLIT-ROBO Rho GTPase activating protein 2
Synonyms: FBP2, 9930124L22Rik, Fnbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14270
Homologene: 52683
Neurl4
Name: neuralized E3 ubiquitin protein ligase 4
Synonyms: 0610025P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216860
Homologene: 13029
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933438D16Rik, 4933439E17Rik, 4930513H15Rik, D14Ertd581e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, RAMP, MYM, FIM, Zfp198
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Kctd3
Name: potassium channel tetramerisation domain containing 3
Synonyms: NY-REN-45, E330032J19Rik, 4930438A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226823
Homologene: 9395
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230393
Homologene: 9842
Rho
Name: rhodopsin
Synonyms: Red Opsin, L opsin, LWS opsin, Long Wavelength Sensitive opsin, Rod Opsin, opsin 2, RP4, Opn2, Ops, Noerg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 212541
Homologene: 68068
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: H-FABP, Fabph-4, Fabph-1, Fabph4, Fabph1, Mdgi, Fabp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 2810040A01Rik, 2810013C04Rik, 5630401D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: Bek, KGFRTr, Fgfr-7, Fgfr-2, Fgfr7, svs, Fgfr2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Il17re
Name: interleukin 17 receptor E
Synonyms: Il25r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 57890
Homologene: 17109
Copg2
Name: coatomer protein complex, subunit gamma 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54160
HGNC: HGNC:2237
Homologene: 56292
Crtc1
Name: CREB regulated transcription coactivator 1
Synonyms: Mect1, TORC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382056
Homologene: 41607
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Cd209d
Name: CD209d antigen
Synonyms: SIGNR3, mSIGNR3, SIGN-R3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170779
HGNC: HGNC:1641
Homologene: 8603
Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Synonyms: I(Kappa)B(alpha), Nfkbi, IkappaBalpha, I-kappaBalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18035
VEGA: 12
HGNC: HGNC:7797
Homologene: 7863
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: DRES9, RdgB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Gm5901
Name: predicted gene 5901
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100503879
Homologene: 18311
Colgalt1
Name: collagen beta(1-O)galactosyltransferase 1
Synonyms: 2810024B22Rik, Glt25d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234407
Homologene: 23465
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Arsi
Name: arylsulfatase i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 545260
Homologene: 44428
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: MCC2, 2210404N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234395
Homologene: 12914
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319555
Homologene: 72261
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192193
Homologene: 33836
Cd200r2
Name: Cd200 receptor 2
Synonyms: CD200 cell surface glycoprotein receptor isoform 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 271375
Homologene: 45557
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, D10Bwg1379e, BIG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Gfus
Name: GDP-L-fucose synthase
Synonyms: Tstap35b, FX, Tsta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22122
VEGA: 15
Homologene: 2484
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Pla2g3
Name: phospholipase A2, group III
Synonyms: 9130003P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237625
Homologene: 9251
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23805
Homologene: 4299
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: D9H3F15S2, D3F15S2h, DNF15S2h, Hgfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15235
Homologene: 7360
Spon2
Name: spondin 2, extracellular matrix protein
Synonyms: M-spondin, Mindin, 2310045I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100689
Homologene: 40843
Arl8a
Name: ADP-ribosylation factor-like 8A
Synonyms: 1110033P22Rik, Arl10b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68724
Homologene: 23600
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11498
Homologene: 86950
Hspb1
Name: heat shock protein 1
Synonyms: Hsp25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15507
HGNC: HGNC:5246
Homologene: 1180
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: G protein-coupled receptor, MrgA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233222
Homologene: 131159
Spns3
Name: spinster homolog 3
Synonyms: 9830002I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77577
Homologene: 45648
Rpl39l
Name: ribosomal protein L39-like
Synonyms: 4930517K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68172
Homologene: 130752
Or10d4
Name: olfactory receptor family 10 subfamily D member 4
Synonyms: GA_x6K02T2PVTD-33365879-33366814, MOR224-13, MOR224-7P, Olfr963
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258087
VEGA: 9
Homologene: 105216
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192652
Homologene: 13983
Mepe
Name: matrix extracellular phosphoglycoprotein with ASARM motif (bone)
Synonyms: OF45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 94111
Homologene: 10623
Pate2
Name: prostate and testis expressed 2
Synonyms: LOC330921, mANLP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330921
Homologene: 86016
Or2av9
Name: olfactory receptor family 2 subfamily AV member 9
Synonyms: GA_x6K02T2NKPP-926908-927915, MOR284-2, Olfr332
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 257932
Homologene: 74137
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 60,251,370 bp
  • A to G, chromosome 1 at 131,332,134 bp
  • T to A, chromosome 1 at 135,152,866 bp
  • A to G, chromosome 1 at 188,981,371 bp
  • A to C, chromosome 2 at 24,806,217 bp
  • T to C, chromosome 2 at 36,091,390 bp
  • C to T, chromosome 2 at 76,752,867 bp
  • A to G, chromosome 4 at 88,121,330 bp
  • C to G, chromosome 4 at 121,054,258 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • A to G, chromosome 5 at 33,215,732 bp
  • A to G, chromosome 5 at 104,337,461 bp
  • T to C, chromosome 5 at 135,889,096 bp
  • A to G, chromosome 6 at 17,534,198 bp
  • T to C, chromosome 6 at 30,810,958 bp
  • T to G, chromosome 6 at 108,852,543 bp
  • C to T, chromosome 6 at 113,462,353 bp
  • T to C, chromosome 6 at 115,935,391 bp
  • T to A, chromosome 6 at 142,248,775 bp
  • T to C, chromosome 7 at 47,589,617 bp
  • G to A, chromosome 7 at 63,099,246 bp
  • G to T, chromosome 7 at 73,507,883 bp
  • G to T, chromosome 7 at 105,377,789 bp
  • T to C, chromosome 7 at 130,227,238 bp
  • A to T, chromosome 7 at 133,023,561 bp
  • A to G, chromosome 8 at 3,878,436 bp
  • T to A, chromosome 8 at 70,388,158 bp
  • T to C, chromosome 8 at 71,394,488 bp
  • C to G, chromosome 8 at 71,623,741 bp
  • T to A, chromosome 8 at 72,662,427 bp
  • T to A, chromosome 8 at 95,706,211 bp
  • T to C, chromosome 9 at 35,669,740 bp
  • G to T, chromosome 9 at 39,669,273 bp
  • T to G, chromosome 9 at 108,082,952 bp
  • A to G, chromosome 10 at 18,597,787 bp
  • A to G, chromosome 10 at 80,313,069 bp
  • A to G, chromosome 10 at 100,561,238 bp
  • A to C, chromosome 11 at 3,493,115 bp
  • T to A, chromosome 11 at 9,275,057 bp
  • T to A, chromosome 11 at 58,490,720 bp
  • T to A, chromosome 11 at 67,340,358 bp
  • G to A, chromosome 11 at 69,907,074 bp
  • T to A, chromosome 11 at 72,550,233 bp
  • C to T, chromosome 11 at 75,449,405 bp
  • T to A, chromosome 12 at 11,457,797 bp
  • A to G, chromosome 12 at 55,490,670 bp
  • A to T, chromosome 12 at 81,420,711 bp
  • T to C, chromosome 12 at 110,693,406 bp
  • T to C, chromosome 12 at 110,926,402 bp
  • A to G, chromosome 14 at 56,920,723 bp
  • A to G, chromosome 14 at 99,242,932 bp
  • G to T, chromosome 15 at 75,926,351 bp
  • C to G, chromosome 15 at 95,966,025 bp
  • A to T, chromosome 16 at 10,174,464 bp
  • T to A, chromosome 16 at 44,909,267 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • T to C, chromosome 19 at 4,110,935 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2393 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040361-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.