Strain Name:
C57BL/6J-MtgxR2394Btlr/Mmmh
Stock Number:
040362-MU
Citation ID:
RRID:MMRRC_040362-MU
Other Names:
R2394 (G1), C57BL/6J-MtgxR2394Btlr
Major Collection:

Gene Information

Htr3a
Name: 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms: 5-HT3 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 15561
VEGA: 9
HGNC: HGNC:5297
Homologene: 671
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Cwc27
Name: CWC27 spliceosome-associated protein
Synonyms: 3110009E13Rik, NY-CO-10, Sdccag10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67285
Homologene: 21192
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240174
VEGA: 17
Homologene: 75175
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22019
Homologene: 2471
Mtrex
Name: Mtr4 exosome RNA helicase
Synonyms: 2610528A15Rik, Skiv2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 72198
VEGA: 13
Homologene: 6257
Dyrk1a
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Synonyms: 2310043O08Rik, D16Ertd493e, Mnbh, D16Ertd272e, Dyrk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13548
HGNC: HGNC:3091
Homologene: 55576
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 84585
Homologene: 11112
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: gp300, Crpd, hensin, ebnerin, CRP-[a], vomeroglandin, CRP-[b], MUCLIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Abca17
Name: ATP-binding cassette, sub-family A (ABC1), member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381072
Homologene: 86807
C3
Name: complement component 3
Synonyms: Plp, acylation stimulating protein, complement factor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Synonyms: P450-1, cytochrome P450 subfamily I, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13076
VEGA: 9
HGNC: HGNC:2595
Homologene: 68062
Ppa1
Name: pyrophosphatase (inorganic) 1
Synonyms: 2010317E03Rik, Pyp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67895
HGNC: HGNC:9226
Homologene: 5356
Itsn2
Name: intersectin 2
Synonyms: Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B, Sh3p18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Olfml2b
Name: olfactomedin-like 2B
Synonyms: 4832415H08Rik, 1110018N05Rik, photomedin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320078
Homologene: 18546
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 77505
Homologene: 131117
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269902
Homologene: 104832
Oog3
Name: oogenesin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100012
Homologene: 129883
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: Liprin-alpha2, E130120L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Gm11639
Name: predicted gene 11639
Synonyms: Efcab15, Gm11639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 105242472
Nlrp14
Name: NLR family, pyrin domain containing 14
Synonyms: Nalp14, 4921520L01Rik, GC-LRR, Nalp-iota
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76858
Homologene: 18531
Atxn7
Name: ataxin 7
Synonyms: Sca7, A430107N12Rik, ataxin-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 246103
VEGA: 14
Homologene: 30967
Ppic
Name: peptidylprolyl isomerase C
Synonyms: cyclophilin C, CyP-20c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 19038
VEGA: 18
HGNC: HGNC:9256
Homologene: 727
Lrrc46
Name: leucine rich repeat containing 46
Synonyms: 1700006D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69297
Homologene: 12307
Ripk2
Name: receptor (TNFRSF)-interacting serine-threonine kinase 2
Synonyms: CARD3, CARDIAK, D4Bwg0615e, RIP2, CCK, 2210420D18Rik, RICK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 192656
Homologene: 37856
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106618
Homologene: 27066
Slco1b2
Name: solute carrier organic anion transporter family, member 1b2
Synonyms: Slc21a6, 7330442B20Rik, mlst-1, Oatp1b2, Slc21a10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 28253
Homologene: 75119
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 22253
Homologene: 2765
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Dync2li1
Name: dynein cytoplasmic 2 light intermediate chain 1
Synonyms: CGI-60, D2lic, LIC3, 4933404O11Rik, mD2LIC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 213575
VEGA: 17
Homologene: 9336
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: Gm29096, Gm6976, 5033413D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 75973
Homologene: 136355
Fam186b
Name: family with sequence similarity 186, member B
Synonyms: EG545136
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 545136
VEGA: 15
Homologene: 69502
Nt5c2
Name: 5'-nucleotidase, cytosolic II
Synonyms: NT5B, PNT5, cN-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 76952
HGNC: HGNC:8022
Homologene: 8158
Thap8
Name: THAP domain containing 8
Synonyms: 1700020L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Obox2
Name: oocyte specific homeobox 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 246792
Homologene: 44937
Ssbp1
Name: single-stranded DNA binding protein 1
Synonyms: mtDBP, G630031O20Rik, 2810480P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 381760
Homologene: 74462
AC161516.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 43,983,186 bp
  • A to G, chromosome 1 at 170,649,750 bp
  • T to C, chromosome 2 at 76,059,061 bp
  • A to T, chromosome 3 at 141,678,131 bp
  • T to C, chromosome 4 at 16,132,774 bp
  • C to G, chromosome 4 at 121,054,258 bp
  • T to A, chromosome 4 at 144,159,314 bp
  • T to C, chromosome 5 at 67,975,132 bp
  • T to A, chromosome 6 at 40,476,809 bp
  • T to C, chromosome 6 at 141,669,374 bp
  • C to T, chromosome 7 at 15,397,010 bp
  • A to T, chromosome 7 at 30,280,628 bp
  • A to G, chromosome 7 at 41,400,195 bp
  • T to A, chromosome 7 at 105,720,231 bp
  • T to C, chromosome 7 at 107,197,824 bp
  • T to A, chromosome 7 at 131,094,734 bp
  • A to G, chromosome 9 at 48,906,343 bp
  • T to A, chromosome 9 at 57,700,149 bp
  • A to G, chromosome 9 at 108,063,536 bp
  • T to G, chromosome 10 at 28,551,717 bp
  • A to G, chromosome 10 at 41,569,898 bp
  • A to G, chromosome 10 at 61,672,384 bp
  • A to G, chromosome 10 at 106,819,490 bp
  • T to C, chromosome 11 at 97,038,831 bp
  • C to A, chromosome 11 at 104,738,295 bp
  • C to A, chromosome 12 at 4,707,005 bp
  • A to C, chromosome 13 at 104,796,434 bp
  • A to T, chromosome 13 at 112,883,168 bp
  • T to C, chromosome 14 at 14,100,237 bp
  • T to C, chromosome 15 at 99,280,177 bp
  • T to A, chromosome 16 at 94,685,132 bp
  • T to C, chromosome 17 at 24,281,216 bp
  • G to A, chromosome 17 at 25,851,455 bp
  • G to A, chromosome 17 at 57,222,303 bp
  • A to G, chromosome 17 at 84,192,334 bp
  • T to A, chromosome 17 at 84,644,747 bp
  • G to A, chromosome 18 at 53,411,047 bp
  • A to G, chromosome 19 at 46,890,067 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2394 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040362-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.