Strain Name:
C57BL/6J-MtgxR2404Btlr/Mmmh
Stock Number:
040370-MU
Citation ID:
RRID:MMRRC_040370-MU
Other Names:
R2404 (G1), C57BL/6J-MtgxR2404Btlr
Major Collection:

Gene Information

Ncam2
Name: neural cell adhesion molecule 2
Synonyms: Ocam, RNCAM, R4B12 antigen, Ncam-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56381
Homologene: 124461
Ubxn2a
Name: UBX domain protein 2A
Synonyms: 6330407P03Rik, Ubxd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217379
Homologene: 17076
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Gdi2
Name: guanosine diphosphate (GDP) dissociation inhibitor 2
Synonyms: Gdi3, GDIB, GDI beta, GDI-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14569
VEGA: 13
HGNC: HGNC:4227
Homologene: 37488
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Ect2
Name: ect2 oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13605
HGNC: HGNC:3155
Homologene: 7298
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: C130040D16Rik, MICAL-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194401
Homologene: 85288
Bcas3
Name: breast carcinoma amplified sequence 3
Synonyms: 1500019F07Rik, K20D4, rudhira, 2610028P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192197
Homologene: 9778
Satb2
Name: special AT-rich sequence binding protein 2
Synonyms: BAP002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 212712
Homologene: 32249
Avpr1a
Name: arginine vasopressin receptor 1A
Synonyms: V1aR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54140
HGNC: HGNC:895
Homologene: 568
Hbs1l
Name: Hbs1-like (S. cerevisiae)
Synonyms: eRFS, 2810035F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56422
VEGA: 10
HGNC: HGNC:4834
Homologene: 68525
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Phlpp, Plekhe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98432
Homologene: 11015
Ttc13
Name: tetratricopeptide repeat domain 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234875
Homologene: 11569
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Mcu
Name: mitochondrial calcium uniporter
Synonyms: 2010012O16Rik, Ccdc109a, D130073L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215999
Homologene: 9916
Dhx57
Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Zc3h12a
Name: zinc finger CCCH type containing 12A
Synonyms: Mcpip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230738
Homologene: 11824
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: 2900022L05Rik, Dnahc2, Dnhd3, D330014H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Trpv2
Name: transient receptor potential cation channel, subfamily V, member 2
Synonyms: OTRPC2, Vrl1, VRL-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22368
Homologene: 7993
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Otud7a
Name: OTU domain containing 7A
Synonyms: Otud7, Cezanne 2 protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 170711
Homologene: 15642
Ac127374.1
Name: Uncharacterized protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Cdh12
Name: cadherin 12
Synonyms: Br-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 215654
HGNC: HGNC:1751
Homologene: 37873
Tshz3
Name: teashirt zinc finger family member 3
Synonyms: A630038G13Rik, teashirt3, Tsh3, Zfp537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243931
Homologene: 10835
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269610
Homologene: 56712
Bnc1
Name: basonuclin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212326
Homologene: 27540
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11981
Homologene: 69194
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74521
Homologene: 12571
Pnmal1
Name: PNMA-like 1
Synonyms: 4930488B01Rik, 0710005I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71691
Homologene: 10073
Sqor
Name: sulfide quinone oxidoreductase
Synonyms: 0610039J17Rik, Sqrdl, 4930557M22Rik, flavo-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59010
Homologene: 10921
Arhgef26
Name: Rho guanine nucleotide exchange factor (GEF) 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 622434
Homologene: 9204
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327963
Homologene: 88945
Spice1
Name: spindle and centriole associated protein 1
Synonyms: Ccdc52, D16Ertd480e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212514
Homologene: 16931
Krt90
Name: keratin 90
Synonyms: 4732456N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239673
Homologene: 72272
4933402N03Rik
Name: RIKEN cDNA 4933402N03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233918
Homologene: 52852
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16552
Homologene: 7796
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 80721
Homologene: 23530
Sp110
Name: Sp110 nuclear body protein
Synonyms: 5031415C07Rik, Ifi75, 5830484A20Rik, 52kDa, Ipr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Olfr1121
Name: olfactory receptor 1121
Synonyms: GA_x6K02T2Q125-48863863-48864807, MOR264-18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258345
Homologene: 74084
Olfr328
Name: olfactory receptor 328
Synonyms: MOR275-2, GA_x6K02T2NKPP-873285-874217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258495
Homologene: 133015
Olfr181
Name: olfactory receptor 181
Synonyms: MOR184-4, GA_x54KRFPKG5P-55145984-55145034
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 259001
Homologene: 74112
Egfl7
Name: EGF-like domain 7
Synonyms: vascular endothelial-statin, Zneu1, VE-statin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 353156
Homologene: 9427
Olfr1369-ps1
Name: olfactory receptor 1369, pseudogene 1
Synonyms: GA_x6K02T2QHY8-12126170-12125935, MOR256-31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 404504
HGNC: HGNC:8281
Aifm2
Name: apoptosis-inducing factor, mitochondrion-associated 2
Synonyms: 5430437E11Rik, PRG3, Amid, D730001I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71361
Homologene: 6862
Sgms1
Name: sphingomyelin synthase 1
Synonyms: 9530058O11Rik, Tmem23, SMS1, SMS1gamma, SMS1beta, SMS1alpha2, SMS1alpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 208449
Homologene: 27040
Atp6v1fnb
Name: Atp6v1f neighbor
Synonyms: Gm9047
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 668210
Homologene: 89367
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 56,948,108 bp
  • T to A, chromosome 1 at 83,023,035 bp
  • A to C, chromosome 1 at 85,577,329 bp
  • C to T, chromosome 1 at 106,172,839 bp
  • G to A, chromosome 2 at 26,589,150 bp
  • A to G, chromosome 2 at 87,372,224 bp
  • A to T, chromosome 2 at 122,808,023 bp
  • T to A, chromosome 2 at 168,675,363 bp
  • G to A, chromosome 3 at 27,131,850 bp
  • T to C, chromosome 3 at 62,428,915 bp
  • C to T, chromosome 3 at 87,802,667 bp
  • A to C, chromosome 4 at 63,170,553 bp
  • T to C, chromosome 4 at 125,119,523 bp
  • T to C, chromosome 4 at 141,477,905 bp
  • C to T, chromosome 4 at 152,367,334 bp
  • G to A, chromosome 6 at 29,473,391 bp
  • G to A, chromosome 6 at 120,959,828 bp
  • A to T, chromosome 7 at 16,960,391 bp
  • A to T, chromosome 7 at 36,770,380 bp
  • A to G, chromosome 7 at 63,697,151 bp
  • A to T, chromosome 7 at 81,968,715 bp
  • T to C, chromosome 7 at 131,139,194 bp
  • T to C, chromosome 8 at 31,737,278 bp
  • A to T, chromosome 8 at 45,341,147 bp
  • C to T, chromosome 8 at 124,678,997 bp
  • T to C, chromosome 9 at 49,037,258 bp
  • A to T, chromosome 10 at 21,296,047 bp
  • A to G, chromosome 10 at 59,467,704 bp
  • A to G, chromosome 10 at 61,728,195 bp
  • T to C, chromosome 10 at 107,686,599 bp
  • T to C, chromosome 10 at 122,449,210 bp
  • A to T, chromosome 11 at 58,551,720 bp
  • A to G, chromosome 11 at 60,189,924 bp
  • G to A, chromosome 11 at 62,581,160 bp
  • A to G, chromosome 11 at 69,437,221 bp
  • A to C, chromosome 11 at 74,084,856 bp
  • T to C, chromosome 11 at 85,354,889 bp
  • T to C, chromosome 12 at 4,883,851 bp
  • A to G, chromosome 12 at 103,581,490 bp
  • T to C, chromosome 13 at 3,564,927 bp
  • T to C, chromosome 13 at 21,115,842 bp
  • G to T, chromosome 14 at 14,733,733 bp
  • C to T, chromosome 15 at 21,537,634 bp
  • T to G, chromosome 15 at 44,550,820 bp
  • A to G, chromosome 15 at 101,554,670 bp
  • C to T, chromosome 16 at 33,989,810 bp
  • T to C, chromosome 16 at 44,366,626 bp
  • G to A, chromosome 16 at 58,925,635 bp
  • A to T, chromosome 16 at 81,490,240 bp
  • A to G, chromosome 17 at 80,254,304 bp
  • A to C, chromosome 18 at 20,510,432 bp
  • G to A, chromosome 19 at 32,159,672 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2404 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040370-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.