Strain Name:
C57BL/6J-MtgxR2405Btlr/Mmmh
Stock Number:
040371-MU
Citation ID:
RRID:MMRRC_040371-MU
Other Names:
R2405 (G1), C57BL/6J-MtgxR2405Btlr
Major Collection:

Gene Information

Gulo
Name: gulonolactone (L-) oxidase
Synonyms: sfx, L-gulono-gamma-lactone oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268756
VEGA: 14
HGNC: HGNC:4695
Homologene: 6566
Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: 5730405M06Rik, Rxrip13, N-CoR, A230020K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Phb
Name: prohibitin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18673
HGNC: HGNC:8912
Homologene: 1980
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP1, SHIP, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Kdm5b
Name: lysine (K)-specific demethylase 5B
Synonyms: PLU-1, Plu1, Rb-Bp2, Jarid1b, 2210016I17Rik, D1Ertd202e, 2010009J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75605
Homologene: 48448
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Cyt28, Gpr56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: Ae2, B3RP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20535
Homologene: 128699
Mysm1
Name: myb-like, SWIRM and MPN domains 1
Synonyms: C530050H10Rik, C130067A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320713
Homologene: 66204
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: Vsp35l, 9030624J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71517
Homologene: 10659
Ppp4r1
Name: protein phosphatase 4, regulatory subunit 1
Synonyms: 3110001J10Rik, Pp4r1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70351
HGNC: HGNC:9320
Homologene: 81737
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: N-ethylmaleimide sensitive factor, SKD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Fxr1
Name: fragile X mental retardation gene 1, autosomal homolog
Synonyms: 1110050J02Rik, Fxr1h, 9530073J07Rik, Fxr1p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Slc25a25
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
Synonyms: 1110030N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227731
Homologene: 62165
Gnpat
Name: glyceronephosphate O-acyltransferase
Synonyms: D1Ertd819e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14712
HGNC: HGNC:4416
Homologene: 40716
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: E430008G22Rik, c-Abl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, 2900054P12Rik, Gcap14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72972
Homologene: 10367
Zdhhc13
Name: zinc finger, DHHC domain containing 13
Synonyms: Hip14l, skc4, kojak, 2410004E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243983
Homologene: 75106
Gbx2
Name: gastrulation brain homeobox 2
Synonyms: MMoxA, Gbx-2, Stra7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14472
HGNC: HGNC:4186
Homologene: 1138
Crnkl1
Name: crooked neck pre-mRNA splicing factor 1
Synonyms: crn, 5730590A01Rik, 1200013P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66877
Homologene: 6462
Ppwd1
Name: peptidylprolyl isomerase domain and WD repeat containing 1
Synonyms: A330090G21Rik, 4632422M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238831
VEGA: 13
Homologene: 9099
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, LOC224126, Hapip, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: TRPC7, LTRPC2, Trrp7, 9830168K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 28240
Homologene: 20709
Hpse
Name: heparanase
Synonyms: Hpa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15442
HGNC: HGNC:5164
Homologene: 68528
Ebf1
Name: early B cell factor 1
Synonyms: Olf-1, O/E-1, Olf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13591
HGNC: HGNC:3126
Homologene: 7297
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Mapk15
Name: mitogen-activated protein kinase 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 332110
Homologene: 16371
Ccny
Name: cyclin Y
Synonyms: 4631402G10Rik, 1700025H17Rik, 5730405I09Rik, 3110050L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67974
VEGA: 18
Homologene: 12219
Psmc1
Name: protease (prosome, macropain) 26S subunit, ATPase 1
Synonyms: S4, P26s4, rpt2, Rpt2/S4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19179
VEGA: 12
HGNC: HGNC:9547
Homologene: 2095
Gm884
Name: predicted gene 884
Synonyms: LOC380730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380730
Homologene: 134511
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp4b, Nalp-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210045
Homologene: 65242
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: Pept2, 8430408C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57738
Homologene: 56912
Cyp2d11
Name: cytochrome P450, family 2, subfamily d, polypeptide 11
Synonyms: Cyp2d, P450-2D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 545123
VEGA: 15
Homologene: 86099
Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
Synonyms: Ntrkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26564
Homologene: 55831
Slc34a2
Name: solute carrier family 34 (sodium phosphate), member 2
Synonyms: Npt2b, D5Ertd227e, NaPi-2b, type IIb Na/Picotransporter
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20531
Homologene: 2297
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320277
Homologene: 23371
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Tmpo
Name: thymopoietin
Synonyms: 5630400D24Rik, TP, lamina-associated polypeptide 2, LAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21917
VEGA: 10
Homologene: 31144
Gabrr1
Name: gamma-aminobutyric acid (GABA) C receptor, subunit rho 1
Synonyms: GABA-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14408
HGNC: HGNC:4090
Homologene: 20470
Klri2
Name: killer cell lectin-like receptor family I member 2
Synonyms: A530090P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320407
Homologene: 86736
Vmn1r60
Name: vomeronasal 1 receptor 60
Synonyms: Gm7184
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 636697
Homologene: 41799
Serpinb9e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9e
Synonyms: NK26, Spi14, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20710
HGNC: HGNC:8955
Homologene: 69093
Hhla1
Name: HERV-H LTR-associating 1
Synonyms: F930104E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 654498
HGNC: HGNC:4904
Homologene: 129987
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 433070
Triml1
Name: tripartite motif family-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244448
Homologene: 18619
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69324
Homologene: 78000
Sgms1
Name: sphingomyelin synthase 1
Synonyms: Tmem23, SMS1alpha2, SMS1, 9530058O11Rik, SMS1gamma, SMS1alpha1, SMS1beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 208449
Homologene: 27040
Serpina3a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3A
Synonyms: alpha-1 antiproteinase,, antitrypsin, 4933406L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74069
HGNC: HGNC:16
Tmem179
Name: transmembrane protein 179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104885
VEGA: 12
Homologene: 16809
Fxyd1
Name: FXYD domain-containing ion transport regulator 1
Synonyms: PML, 1110006M24Rik, PLM, 0610012C17Rik, phospholemman
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56188
HGNC: HGNC:4025
Homologene: 3691
Gm5741
Name: predicted gene 5741
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100503710
Homologene: 133234
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 46,362,954 bp
  • A to G, chromosome 1 at 87,699,729 bp
  • G to T, chromosome 1 at 89,930,908 bp
  • T to A, chromosome 1 at 134,609,016 bp
  • T to A, chromosome 1 at 150,860,341 bp
  • T to C, chromosome 2 at 31,800,974 bp
  • C to T, chromosome 2 at 32,417,719 bp
  • A to T, chromosome 2 at 145,928,157 bp
  • A to G, chromosome 2 at 150,820,775 bp
  • T to A, chromosome 3 at 34,061,854 bp
  • A to T, chromosome 4 at 33,157,110 bp
  • T to C, chromosome 4 at 94,967,973 bp
  • A to G, chromosome 5 at 24,435,601 bp
  • A to G, chromosome 5 at 53,058,181 bp
  • A to G, chromosome 5 at 100,708,771 bp
  • A to T, chromosome 6 at 129,732,266 bp
  • A to T, chromosome 6 at 141,481,242 bp
  • A to G, chromosome 7 at 5,544,913 bp
  • A to G, chromosome 7 at 10,714,728 bp
  • G to A, chromosome 7 at 31,053,878 bp
  • A to G, chromosome 7 at 48,822,730 bp
  • G to C, chromosome 7 at 118,792,595 bp
  • T to C, chromosome 8 at 43,130,283 bp
  • A to G, chromosome 8 at 85,067,641 bp
  • T to A, chromosome 8 at 95,006,815 bp
  • T to A, chromosome 8 at 124,878,676 bp
  • T to A, chromosome 10 at 50,731,678 bp
  • A to G, chromosome 10 at 77,934,724 bp
  • C to A, chromosome 10 at 91,163,354 bp
  • T to A, chromosome 11 at 44,991,522 bp
  • T to G, chromosome 11 at 62,438,326 bp
  • T to C, chromosome 11 at 95,675,268 bp
  • T to C, chromosome 11 at 103,620,984 bp
  • C to T, chromosome 11 at 103,930,752 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • A to T, chromosome 12 at 25,011,509 bp
  • G to A, chromosome 12 at 100,120,103 bp
  • A to T, chromosome 12 at 104,121,318 bp
  • A to G, chromosome 12 at 112,501,913 bp
  • T to A, chromosome 13 at 33,260,080 bp
  • G to A, chromosome 13 at 53,130,944 bp
  • G to A, chromosome 13 at 104,213,718 bp
  • G to A, chromosome 14 at 36,938,669 bp
  • A to G, chromosome 14 at 65,991,028 bp
  • C to A, chromosome 15 at 9,626,034 bp
  • A to T, chromosome 15 at 65,936,311 bp
  • T to A, chromosome 15 at 75,994,948 bp
  • C to T, chromosome 15 at 82,389,266 bp
  • C to T, chromosome 16 at 33,989,810 bp
  • G to A, chromosome 16 at 36,751,837 bp
  • T to A, chromosome 17 at 18,597,840 bp
  • C to T, chromosome 17 at 65,811,346 bp
  • A to G, chromosome 18 at 9,353,480 bp
  • G to A, chromosome 19 at 32,159,672 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2405 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040371-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.