Strain Name:
C57BL/6J-MtgxR2406Btlr/Mmmh
Stock Number:
040372-MU
Citation ID:
RRID:MMRRC_040372-MU
Other Names:
R2406 (G1), C57BL/6J-MtgxR2406Btlr
Major Collection:

Gene Information

Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Synonyms: RPTP-LAR, LAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: TRAM-1, Src3, pCIP, KAT13B, bHLHe42, RAC3, 2010305B15Rik, AIB1, TRAM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Bwf1, Alfy, 2610509D04Rik, Bchs, Ggtb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72145
Homologene: 22855
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Hsf2
Name: heat shock factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 15500
VEGA: 10
HGNC: HGNC:5225
Homologene: 37931
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: SKD2, N-ethylmaleimide sensitive factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9430093I07Rik, 9630002H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78455
Homologene: 8918
Pip5k1c
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
Synonyms: PIP5KIgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18717
HGNC: HGNC:8996
Homologene: 69032
Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Synonyms: PHAS-I, 4e-bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13685
HGNC: HGNC:3288
Homologene: 3021
Ptcd3
Name: pentatricopeptide repeat domain 3
Synonyms: 2810422B04Rik, 2610034F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 69956
Homologene: 41211
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230848
Homologene: 8912
Ubtf
Name: upstream binding transcription factor, RNA polymerase I
Synonyms: UBF, UBF1, A930005G04Rik, Tcfubf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 21429
Homologene: 7970
Uty
Name: ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
Synonyms: Hydb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 22290
2300002M23Rik
Name: RIKEN cDNA 2300002M23 gene
Synonyms: emprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 69542
Homologene: 49368
Sgta
Name: small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
Synonyms: D10Ertd190e, 5330427H01Rik, Sgt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 52551
VEGA: 10
Homologene: 31122
Top3a
Name: topoisomerase (DNA) III alpha
Synonyms: Top IIIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 21975
Homologene: 3394
AW554918
Name: expressed sequence AW554918
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225289
Homologene: 52652
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: 5530401A10Rik, Jhdm1a, Fbl7, lalina, Gm4560, Fbxl11, Cxxc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225876
Homologene: 56564
Vps37d
Name: vacuolar protein sorting 37D
Synonyms: Wbscr24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 194309
Homologene: 45580
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Fam38b, Piezo2, 9030411M15Rik, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 667742
Homologene: 49695
Colgalt1
Name: collagen beta(1-O)galactosyltransferase 1
Synonyms: 2810024B22Rik, Glt25d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234407
Homologene: 23465
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: PKHDL1, fibrocystin L, D86 mRNA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 192190
Homologene: 16332
Mapk15
Name: mitogen-activated protein kinase 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 332110
Homologene: 16371
Gm11639
Name: predicted gene 11639
Synonyms: Efcab15, Gm11639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 105242472
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242627
Homologene: 135888
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238455
Homologene: 18813
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: X83337, 1810073P09Rik, ESTM15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 75607
Homologene: 19155
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MYH-2B, Minmus, Minimsc, Myhsf, MM, MyHC-IIb, MHC2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Chaf1b
Name: chromatin assembly factor 1, subunit B (p60)
Synonyms: CAF-IP60, MPHOSPH7, 2600017H24Rik, CAF-I 60 kDa subunit, CAF1, CAF1A, CAF1P60, CAF-1 subunit B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243961
Homologene: 22949
Dennd4b
Name: DENN/MADD domain containing 4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229541
Homologene: 28281
Pacsin2
Name: protein kinase C and casein kinase substrate in neurons 2
Synonyms: Syndapin II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 23970
VEGA: 15
HGNC: HGNC:8571
Homologene: 21414
Tmc4
Name: transmembrane channel-like gene family 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 353499
Homologene: 16971
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, Rsn, 1110007I12Rik, CLIP-170, Clip 170, 4631429H07Rik, Clip50, restin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56430
Homologene: 74455
C9
Name: complement component 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Fam205a1
Name: family with sequence similarity 205, member A1
Synonyms: Gm12429
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433698
Homologene: 79022
Olfr1447
Name: olfactory receptor 1447
Synonyms: MOR202-3, GA_x6K02T2RE5P-3231251-3230331
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258698
Homologene: 74233
Setd7
Name: SET domain containing (lysine methyltransferase) 7
Synonyms: Set7, 1600028F23Rik, KMT7, Set7/9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 73251
Homologene: 12741
AC140364.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Fbxw5
Name: F-box and WD-40 domain protein 5
Synonyms: Fbw5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 30839
Homologene: 8496
Ifih1
Name: interferon induced with helicase C domain 1
Synonyms: MDA-5, Helicard, MDA5, 9130009C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71586
Homologene: 32535
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Stox1
Name: storkhead box 1
Synonyms: 4732470K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216021
Homologene: 17649
Gm10650
Name: predicted gene 10650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Naip3
Name: NLR family, apoptosis inhibitory protein 3
Synonyms: Naip-rs5, EG667838, Birc1c, Naip3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 667838
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 25,504,183 bp
  • A to G, chromosome 2 at 62,607,103 bp
  • T to C, chromosome 2 at 76,950,155 bp
  • T to C, chromosome 2 at 166,055,359 bp
  • A to G, chromosome 3 at 51,542,676 bp
  • C to T, chromosome 3 at 90,275,488 bp
  • A to G, chromosome 3 at 128,039,881 bp
  • A to T, chromosome 4 at 42,851,696 bp
  • A to G, chromosome 4 at 113,942,667 bp
  • T to C, chromosome 4 at 118,269,304 bp
  • T to A, chromosome 4 at 136,998,568 bp
  • A to T, chromosome 5 at 8,180,064 bp
  • T to C, chromosome 5 at 101,888,259 bp
  • T to C, chromosome 5 at 123,603,660 bp
  • A to G, chromosome 5 at 135,074,385 bp
  • T to C, chromosome 6 at 71,888,647 bp
  • A to G, chromosome 7 at 3,671,026 bp
  • A to G, chromosome 7 at 44,356,952 bp
  • A to T, chromosome 7 at 44,521,725 bp
  • A to G, chromosome 8 at 27,273,334 bp
  • G to A, chromosome 8 at 71,617,668 bp
  • C to T, chromosome 10 at 57,497,546 bp
  • T to C, chromosome 10 at 62,664,166 bp
  • T to C, chromosome 10 at 81,051,247 bp
  • T to A, chromosome 10 at 81,309,024 bp
  • A to G, chromosome 11 at 60,756,012 bp
  • A to G, chromosome 11 at 67,259,174 bp
  • A to T, chromosome 11 at 102,308,702 bp
  • C to T, chromosome 11 at 103,930,752 bp
  • A to T, chromosome 11 at 104,720,631 bp
  • G to A, chromosome 11 at 107,686,552 bp
  • T to C, chromosome 12 at 111,302,124 bp
  • T to C, chromosome 12 at 119,465,611 bp
  • G to T, chromosome 13 at 49,061,488 bp
  • T to C, chromosome 13 at 91,972,240 bp
  • C to T, chromosome 13 at 100,362,146 bp
  • T to C, chromosome 15 at 6,483,299 bp
  • T to A, chromosome 15 at 44,564,237 bp
  • T to C, chromosome 15 at 75,998,848 bp
  • A to T, chromosome 15 at 83,385,112 bp
  • T to C, chromosome 16 at 93,900,155 bp
  • T to A, chromosome 17 at 35,568,455 bp
  • A to G, chromosome 18 at 25,340,287 bp
  • A to T, chromosome 18 at 63,022,525 bp
  • T to C, chromosome 19 at 4,322,518 bp
  • A to G, chromosome 19 at 12,901,627 bp
  • A to G, chromosome Y at 1,245,526 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2406 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040372-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.