Strain Name:
C57BL/6J-MtgxR2409Btlr/Mmmh
Stock Number:
040375-MU
Citation ID:
RRID:MMRRC_040375-MU
Other Names:
R2409 (G1), C57BL/6J-MtgxR2409Btlr
Major Collection:

Gene Information

Fabp7
Name: fatty acid binding protein 7, brain
Synonyms: B-FABP, Blbp, BFABP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12140
HGNC: HGNC:3562
Homologene: 37880
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF kappaB1, p50 subunit of NF kappaB, p50/p105, p50, nuclear factor kappaB p50, NF-kappaB, NF-kappaB p50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: SKD2, N-ethylmaleimide sensitive factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Rgs5
Name: regulator of G-protein signaling 5
Synonyms: 1110070A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19737
Homologene: 2682
Trim71
Name: tripartite motif-containing 71
Synonyms: LOC382112, lin-41, mlin-41, Lin41, 2610206G21Rik, 636931, mLin41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 636931
Homologene: 9076
Dpy19l2
Name: dpy-19-like 2 (C. elegans)
Synonyms: 4932443J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320752
VEGA: 9
Homologene: 77569
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Septin9
Name: septin 9
Synonyms: SL3-3 integration site 1, Sint1, Msf, MSF1, PNUTL4, Sept9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Extl3
Name: exostosin-like glycosyltransferase 3
Synonyms: 2900009G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54616
VEGA: 14
HGNC: HGNC:3518
Homologene: 1103
Prdm10
Name: PR domain containing 10
Synonyms: tristanin, LOC382066
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382066
Homologene: 45718
Adamts13
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209012
Homologene: 41205
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637896
Homologene: 115466
Ac127374.1
Name: Uncharacterized protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Adamts7
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Trim26
Name: tripartite motif-containing 26
Synonyms: Zfp173
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22670
Homologene: 31159
Myo1f
Name: myosin IF
Synonyms: C330006B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17916
HGNC: HGNC:7600
Homologene: 56276
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625068
Homologene: 129606
Sh2b1
Name: SH2B adaptor protein 1
Synonyms: Irip, SH2-Bb, SH2-B, Sh2bpsm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20399
Homologene: 32122
Il3ra
Name: interleukin 3 receptor, alpha chain
Synonyms: IL-3 receptor alpha chain, CD123, SUT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16188
VEGA: 14
HGNC: HGNC:6012
Homologene: 48088
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76713
Homologene: 66347
Sec14l4
Name: SEC14-like lipid binding 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103655
Homologene: 68807
Cyp3a16
Name: cytochrome P450, family 3, subfamily a, polypeptide 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13114
HGNC: HGNC:2638
Homologene: 133568
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Dyrk2
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Cib2
Name: calcium and integrin binding family member 2
Synonyms: calcium binding protein Kip2, 2810434I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56506
Homologene: 4653
Olfr77
Name: olfactory receptor 77
Synonyms: 18A, MOR143-1, GA_x6K02T2PVTD-13660026-13660964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258336
Homologene: 133688
Septin1
Name: septin 1
Synonyms: PNUTL3, Diff6, Sept1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54204
HGNC: HGNC:2879
Homologene: 23009
Fxyd1
Name: FXYD domain-containing ion transport regulator 1
Synonyms: phospholemman, PML, 0610012C17Rik, PLM, 1110006M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56188
HGNC: HGNC:4025
Homologene: 3691
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 169,676,882 bp
  • A to G, chromosome 2 at 26,978,362 bp
  • C to T, chromosome 3 at 135,613,943 bp
  • C to T, chromosome 5 at 8,738,747 bp
  • T to C, chromosome 5 at 145,440,367 bp
  • G to A, chromosome 7 at 31,053,878 bp
  • T to C, chromosome 7 at 45,280,326 bp
  • T to A, chromosome 7 at 86,920,745 bp
  • C to T, chromosome 7 at 126,471,479 bp
  • T to C, chromosome 7 at 127,215,971 bp
  • T to C, chromosome 8 at 31,737,278 bp
  • G to T, chromosome 8 at 45,040,530 bp
  • G to T, chromosome 9 at 19,920,776 bp
  • G to C, chromosome 9 at 19,920,781 bp
  • A to G, chromosome 9 at 24,658,628 bp
  • A to G, chromosome 9 at 31,349,122 bp
  • A to G, chromosome 9 at 54,545,467 bp
  • T to A, chromosome 9 at 90,180,687 bp
  • A to T, chromosome 9 at 114,513,713 bp
  • C to A, chromosome 9 at 121,258,834 bp
  • A to G, chromosome 10 at 57,785,676 bp
  • A to G, chromosome 10 at 118,860,627 bp
  • A to G, chromosome 10 at 130,392,071 bp
  • T to C, chromosome 11 at 4,040,048 bp
  • C to T, chromosome 11 at 103,930,752 bp
  • T to A, chromosome 11 at 117,360,461 bp
  • A to G, chromosome 12 at 11,249,164 bp
  • G to A, chromosome 14 at 14,349,377 bp
  • CCGTGTTT to C, chromosome 14 at 62,406,179 bp
  • T to C, chromosome 14 at 65,077,568 bp
  • A to G, chromosome 17 at 33,576,667 bp
  • C to A, chromosome 17 at 36,851,003 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2409 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040375-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.