Strain Name:
C57BL/6J-MtgxR2414Btlr/Mmmh
Stock Number:
040378-MU
Citation ID:
RRID:MMRRC_040378-MU
Other Names:
R2414 (G1), C57BL/6J-MtgxR2414Btlr
Major Collection:

Gene Information

Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108096
Homologene: 56603
Msi2
Name: musashi RNA-binding protein 2
Synonyms: msi2h, Musashi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76626
Homologene: 62199
Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99371
Homologene: 111880
Tesk2
Name: testis-specific kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230661
Homologene: 5188
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217342
Homologene: 11113
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319817
Homologene: 28276
Aspscr1
Name: alveolar soft part sarcoma chromosome region, candidate 1 (human)
Synonyms: ASPCR1, RCC17, ASPC, 1190006K01Rik, TUG, ASPL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68938
Homologene: 41550
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Rnpc3
Name: RNA-binding region (RNP1, RRM) containing 3
Synonyms: C030014B17Rik, 2810441O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67225
Homologene: 9746
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA2, RPA116, 128kDa, D630020H17Rik, Rpo1-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20017
Homologene: 7133
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
BC002059
Name: cDNA sequence BC002059
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213811
Irf7
Name: interferon regulatory factor 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54123
HGNC: HGNC:6122
Homologene: 128624
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100317
Homologene: 11764
Cilp
Name: cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Synonyms: C130036G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214425
HGNC: HGNC:1980
Homologene: 2679
Tub
Name: tubby bipartite transcription factor
Synonyms: rd5, tub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22141
Homologene: 31147
Txnip
Name: thioredoxin interacting protein
Synonyms: THIF, VDUP1, mVDUP1, Hyplip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215456
Homologene: 19037
Hpd
Name: 4-hydroxyphenylpyruvic acid dioxygenase
Synonyms: Hppd, Laf, Flp, Fla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15445
HGNC: HGNC:5147
Homologene: 1620
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Alpk3
Name: alpha-kinase 3
Synonyms: Midori
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 116904
Homologene: 10813
Nol4
Name: nucleolar protein 4
Synonyms: 4930568N03Rik, LOC383304, 1700013J13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: 1810012I01Rik, CIP85, Rutbc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105835
Homologene: 9249
Cpn2
Name: carboxypeptidase N, polypeptide 2
Synonyms: 1300018K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71756
VEGA: 16
HGNC: HGNC:2313
Homologene: 19487
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 29816
Homologene: 78348
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: 4632412N22Rik, Fam179a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320159
Homologene: 65315
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPTI, M-CPT I, Cpt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Zfp503
Name: zinc finger protein 503
Synonyms: B830002A16Rik, Nolz-1, Nolz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218820
Homologene: 41888
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242409
Homologene: 72894
Hoxc9
Name: homeobox C9
Synonyms: Hox-3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15427
HGNC: HGNC:5130
Homologene: 130558
Ttll11
Name: tubulin tyrosine ligase-like family, member 11
Synonyms: 4932702F08Rik, D2Ertd624e, 4933424A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74410
Homologene: 77534
Ackr2
Name: atypical chemokine receptor 2
Synonyms: D6, Ccbp2, chemokine decoy receptor D6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 59289
VEGA: 9
HGNC: HGNC:1565
Homologene: 992
Lrrc34
Name: leucine rich repeat containing 34
Synonyms: 1700007J06Rik, Spata34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71827
Homologene: 27419
Acer2
Name: alkaline ceramidase 2
Synonyms: 2410116I05Rik, Asah3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230379
Homologene: 14986
H2bc21
Name: H2B clustered histone 21
Synonyms: Hist2h2be
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 319190
HGNC: HGNC:4761
Homologene: 128594
Cep112
Name: centrosomal protein 112
Synonyms: 1700001M19Rik, 1700029K01Rik, 8430407H02Rik, Macoco, Ccdc46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76380
Homologene: 44915
Ttll8
Name: tubulin tyrosine ligase-like family, member 8
Synonyms: 1700019P01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239591
Homologene: 52766
Vamp8
Name: vesicle-associated membrane protein 8
Synonyms: endobrevin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22320
Homologene: 37846
Surf1
Name: surfeit gene 1
Synonyms: Surf-1, 0610010F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20930
Homologene: 2387
Epor
Name: erythropoietin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13857
VEGA: 9
HGNC: HGNC:3416
Homologene: 95
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 26,916,283 bp
  • A to G, chromosome 2 at 35,979,534 bp
  • A to T, chromosome 2 at 37,399,819 bp
  • T to C, chromosome 2 at 127,433,723 bp
  • A to G, chromosome 2 at 129,103,134 bp
  • A to G, chromosome 2 at 166,845,504 bp
  • T to A, chromosome 3 at 30,634,562 bp
  • T to A, chromosome 3 at 96,221,434 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • C to T, chromosome 3 at 113,611,316 bp
  • A to G, chromosome 4 at 43,673,892 bp
  • T to C, chromosome 4 at 86,900,634 bp
  • T to C, chromosome 4 at 116,801,757 bp
  • A to T, chromosome 4 at 126,868,691 bp
  • C to T, chromosome 5 at 123,177,524 bp
  • T to C, chromosome 5 at 124,001,243 bp
  • T to A, chromosome 6 at 18,255,484 bp
  • C to T, chromosome 6 at 72,388,343 bp
  • A to G, chromosome 6 at 140,550,856 bp
  • A to G, chromosome 6 at 142,236,250 bp
  • C to A, chromosome 7 at 81,092,753 bp
  • A to G, chromosome 7 at 109,027,033 bp
  • A to G, chromosome 7 at 141,263,586 bp
  • T to C, chromosome 9 at 6,935,370 bp
  • T to A, chromosome 9 at 21,959,489 bp
  • A to G, chromosome 9 at 65,274,645 bp
  • C to A, chromosome 9 at 121,908,974 bp
  • A to G, chromosome 11 at 67,250,768 bp
  • A to G, chromosome 11 at 88,716,547 bp
  • A to G, chromosome 11 at 108,752,582 bp
  • T to C, chromosome 11 at 116,548,857 bp
  • T to C, chromosome 11 at 120,689,222 bp
  • C to A, chromosome 14 at 21,985,964 bp
  • A to G, chromosome 15 at 81,006,745 bp
  • A to G, chromosome 15 at 88,936,133 bp
  • G to A, chromosome 15 at 89,420,080 bp
  • A to T, chromosome 15 at 102,984,108 bp
  • T to C, chromosome 16 at 30,260,574 bp
  • T to C, chromosome 17 at 16,973,670 bp
  • T to G, chromosome 17 at 71,716,309 bp
  • T to C, chromosome 18 at 22,823,572 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2414 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040378-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.