Strain Name:
C57BL/6J-MtgxR2415Btlr/Mmmh
Stock Number:
040379-MU
Citation ID:
RRID:MMRRC_040379-MU
Other Names:
R2415 (G1), C57BL/6J-MtgxR2415Btlr
Major Collection:

Gene Information

Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77569
Homologene: 18953
Hdac1
Name: histone deacetylase 1
Synonyms: HD1, RPD3, MommeD5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433759
HGNC: HGNC:4852
Homologene: 68426
Ano6
Name: anoctamin 6
Synonyms: Tmem16f, 2900059G15Rik, F730003B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: C130052G03Rik, LOC237877
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237877
Homologene: 32611
Ddx56
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
Synonyms: NOH61, D11Ertd619e, 2600001H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52513
Homologene: 6498
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22722
Homologene: 7604
Kcnk5
Name: potassium channel, subfamily K, member 5
Synonyms: TASK-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16529
VEGA: 14
HGNC: HGNC:6280
Homologene: 2773
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: opt, Pcp1, InsP3R type I, wblo, P400, Ip3r, Pcp-1, Itpr-1, IP3R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Gabpa
Name: GA repeat binding protein, alpha
Synonyms: GABPalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14390
HGNC: HGNC:4071
Homologene: 1543
Ubqln1
Name: ubiquilin 1
Synonyms: DA41, 1110046H03Rik, 1810030E05Rik, D13Ertd372e, Dsk2, XDRP1, Plic-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56085
VEGA: 13
Homologene: 137258
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99480
Homologene: 124162
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20662
VEGA: 17
Homologene: 4117
Surf6
Name: surfeit gene 6
Synonyms: Surf-6, D2Wsu129e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20935
Homologene: 133981
Eva1c
Name: eva-1 homolog C (C. elegans)
Synonyms: Fam176c, 4931408A02Rik, 1700092M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70967
Homologene: 14383
Pdia4
Name: protein disulfide isomerase associated 4
Synonyms: Erp72, ERp72, Cai, U48620
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12304
Homologene: 21020
Sec24b
Name: Sec24 related gene family, member B (S. cerevisiae)
Synonyms: SEC24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99683
Homologene: 55968
Efl1
Name: elongation factor like GTPase 1
Synonyms: 4932434J20Rik, D7Ertd791e, Eftud1, 6030468D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101592
Homologene: 11599
Nbeal1
Name: neurobeachin like 1
Synonyms: A530083I02Rik, A530050O19Rik, 2310076G13Rik, ALS2CR17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Khdc1b
Name: KH domain containing 1B
Synonyms: Khdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98582
Homologene: 134524
Zfp750
Name: zinc finger protein 750
Synonyms: A030007D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319530
Homologene: 36423
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Kcnma3, Slo3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16532
Homologene: 7392
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
S100pbp
Name: S100P binding protein
Synonyms: 4930429A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74648
Homologene: 81892
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: Heatr7a, D330001F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223658
Homologene: 44882
Tspan15
Name: tetraspanin 15
Synonyms: Tm4sf15, 2700063A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70423
VEGA: 10
Homologene: 22716
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620928
Homologene: 115466
Myo15b
Name: myosin XVB
Synonyms: E330039G21Rik, LOC380737, LOC217328
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217328
Per3
Name: period circadian clock 3
Synonyms: 2810049O06Rik, mPer3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18628
HGNC: HGNC:8847
Homologene: 7886
Nudt12
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 12
Synonyms: 0610016O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67993
Homologene: 44188
Rxfp1
Name: relaxin/insulin-like family peptide receptor 1
Synonyms: Lgr7, LOC381489
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381489
Homologene: 11007
Fbxw21
Name: F-box and WD-40 domain protein 21
Synonyms: E330009P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320082
Homologene: 110776
Lpgat1
Name: lysophosphatidylglycerol acyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226856
Homologene: 8914
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp4c, Nalp-alpha, Rnh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83564
Homologene: 75315
Ky
Name: kyphoscoliosis peptidase
Synonyms: D9Mgc44e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16716
Homologene: 11506
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Mettl22
Name: methyltransferase like 22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239706
Homologene: 16619
Efhb
Name: EF hand domain family, member B
Synonyms: 4921525D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211482
VEGA: 17
Homologene: 16982
Pla1a
Name: phospholipase A1 member A
Synonyms: Ps-pla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 85031
VEGA: 16
Homologene: 9294
Fxyd1
Name: FXYD domain-containing ion transport regulator 1
Synonyms: PML, 1110006M24Rik, PLM, 0610012C17Rik, phospholemman
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56188
HGNC: HGNC:4025
Homologene: 3691
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 21,384,310 bp
  • T to A, chromosome 1 at 60,265,024 bp
  • G to T, chromosome 1 at 191,759,959 bp
  • C to T, chromosome 2 at 26,892,262 bp
  • A to G, chromosome 2 at 168,934,945 bp
  • A to G, chromosome 3 at 79,663,319 bp
  • T to C, chromosome 3 at 122,276,537 bp
  • A to T, chromosome 3 at 129,996,080 bp
  • A to T, chromosome 4 at 129,181,821 bp
  • A to C, chromosome 4 at 129,522,961 bp
  • A to C, chromosome 4 at 151,012,690 bp
  • T to C, chromosome 5 at 66,974,634 bp
  • G to T, chromosome 6 at 47,806,556 bp
  • T to C, chromosome 6 at 108,406,078 bp
  • A to G, chromosome 7 at 6,066,048 bp
  • G to A, chromosome 7 at 31,053,878 bp
  • T to A, chromosome 7 at 82,697,967 bp
  • T to C, chromosome 7 at 85,872,223 bp
  • A to T, chromosome 8 at 25,910,878 bp
  • G to T, chromosome 9 at 102,541,891 bp
  • G to T, chromosome 9 at 109,156,401 bp
  • A to G, chromosome 10 at 62,201,791 bp
  • G to A, chromosome 10 at 106,858,411 bp
  • G to A, chromosome 11 at 6,261,727 bp
  • T to C, chromosome 11 at 80,094,251 bp
  • T to G, chromosome 11 at 115,879,564 bp
  • T to C, chromosome 11 at 121,512,479 bp
  • G to A, chromosome 13 at 58,178,031 bp
  • T to A, chromosome 14 at 7,929,932 bp
  • T to C, chromosome 14 at 20,141,812 bp
  • A to T, chromosome 14 at 35,450,369 bp
  • A to G, chromosome 15 at 76,421,211 bp
  • A to T, chromosome 15 at 95,962,280 bp
  • T to C, chromosome 16 at 8,488,648 bp
  • T to A, chromosome 16 at 38,407,750 bp
  • T to C, chromosome 16 at 84,844,368 bp
  • A to C, chromosome 16 at 90,897,465 bp
  • T to A, chromosome 17 at 46,543,438 bp
  • A to T, chromosome 17 at 53,463,096 bp
  • A to G, chromosome 17 at 59,006,608 bp
  • G to C, chromosome 17 at 80,408,755 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2415 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040379-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.