Strain Name:
C57BL/6J-MtgxR2435Btlr/Mmmh
Stock Number:
040396-MU
Citation ID:
RRID:MMRRC_040396-MU
Other Names:
R2435 (G1), C57BL/6J-MtgxR2435Btlr
Major Collection:

Gene Information

Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54445
Homologene: 41325
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: 5830434P21Rik, Bat2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227723
Homologene: 106649
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hsp90, Hsp86-1, Hsp89, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75786
Homologene: 8844
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: SKD2, N-ethylmaleimide sensitive factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Gpi1
Name: glucose-6-phosphate isomerase 1
Synonyms: Org, Gpi-1t, Gpi-1, Gpi-1s, Gpi-1r, Gpi1-t, Gpi1-s, Gpi1-r, MF, maturation factor, NK, AMF, autocrine motility factor, neuroleukin, NK/GPI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14751
HGNC: HGNC:4458
Homologene: 145
Unc13d
Name: unc-13 homolog D
Synonyms: Munc13-4, 2610108D09Rik, Jinx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70450
Homologene: 26714
Rbmxl2
Name: RNA binding motif protein, X-linked-like 2
Synonyms: 1700012H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76572
Homologene: 113740
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66585
Homologene: 3538
Clec4e
Name: C-type lectin domain family 4, member e
Synonyms: Mincle, Clecsf9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56619
Homologene: 22809
Acvr1
Name: activin A receptor, type 1
Synonyms: ActR-I, ALK2, Acvr, Acvrlk2, ActRIA, SKR1, Tsk7L, D330013D15Rik, Alk8, Alk-2, Acvr1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Cd34
Name: CD34 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12490
HGNC: HGNC:1662
Homologene: 1343
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: CD103, alpha-E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232748
Homologene: 17147
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 2810455B10Rik, PAR3beta, PAR3L, PAR3B, 2010002N16Rik, Als2cr19, 1810008K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72823
Homologene: 35389
Fshr
Name: follicle stimulating hormone receptor
Synonyms: follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14309
VEGA: 17
HGNC: HGNC:3969
Homologene: 117
Gypa
Name: glycophorin A
Synonyms: CD235a, GPA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14934
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: Kir3.2, GIRK2, KCNJ7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: merg1a, ether a go-go related, M-erg, LQT, Lqt2, ERG1, merg1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Ivns1abp
Name: influenza virus NS1A binding protein
Synonyms: Nd1-S, Nd1-L, NS-1, ND1, HSPC068, NS1-BP, 1190004M08Rik, 1700126I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 117198
Homologene: 31384
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 0610043A03Rik, 2210420P05Rik, 2600014C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70297
Homologene: 45639
Serpini2
Name: serine (or cysteine) peptidase inhibitor, clade I, member 2
Synonyms: 1810006A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67931
HGNC: HGNC:8945
Homologene: 21248
A1cf
Name: APOBEC1 complementation factor
Synonyms: ACF, apobec-1 complementation factor, 1810073H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69865
VEGA: 19
Homologene: 16363
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Ugt2b5
Name: UDP glucuronosyltransferase 2 family, polypeptide B5
Synonyms: Udpgt-3, m-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22238
Homologene: 137225
Or4k15
Name: olfactory receptor family 4 subfamily K member 15
Synonyms: GA_x6K02T2PMLR-5817082-5818056, MOR246-2, Olfr727
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258316
Homologene: 84571
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434117
Homologene: 113703
Or6c217
Name: olfactory receptor family 6 subfamily C member 217
Synonyms: GA_x6K02T2PULF-11581263-11580331, MOR113-3, Olfr815
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258665
Mblac2
Name: metallo-beta-lactamase domain containing 2
Synonyms: 2900024O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72852
VEGA: 13
Homologene: 15174
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 62,587,738 bp
  • T to C, chromosome 1 at 151,363,310 bp
  • T to A, chromosome 1 at 194,939,026 bp
  • T to G, chromosome 1 at 194,959,768 bp
  • T to A, chromosome 2 at 13,318,272 bp
  • A to T, chromosome 2 at 32,219,729 bp
  • T to C, chromosome 2 at 58,479,692 bp
  • T to A, chromosome 2 at 91,581,145 bp
  • A to G, chromosome 3 at 72,911,904 bp
  • T to C, chromosome 3 at 75,258,168 bp
  • T to A, chromosome 4 at 88,644,129 bp
  • A to G, chromosome 4 at 130,384,551 bp
  • A to T, chromosome 4 at 144,362,903 bp
  • A to G, chromosome 5 at 24,326,347 bp
  • T to C, chromosome 5 at 87,139,606 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • G to T, chromosome 5 at 124,762,865 bp
  • T to C, chromosome 5 at 137,438,574 bp
  • G to T, chromosome 6 at 42,630,364 bp
  • A to G, chromosome 6 at 123,288,896 bp
  • C to A, chromosome 7 at 10,053,099 bp
  • G to A, chromosome 7 at 34,205,829 bp
  • C to A, chromosome 7 at 107,210,331 bp
  • A to T, chromosome 7 at 141,818,104 bp
  • C to T, chromosome 8 at 48,287,953 bp
  • G to T, chromosome 8 at 80,506,768 bp
  • A to C, chromosome 8 at 109,650,702 bp
  • A to G, chromosome 10 at 58,294,780 bp
  • A to G, chromosome 10 at 88,820,891 bp
  • G to T, chromosome 10 at 129,902,304 bp
  • T to A, chromosome 11 at 73,121,937 bp
  • C to T, chromosome 11 at 103,930,752 bp
  • A to G, chromosome 11 at 116,068,688 bp
  • T to A, chromosome 12 at 25,040,449 bp
  • T to A, chromosome 12 at 110,695,680 bp
  • C to A, chromosome 12 at 110,695,681 bp
  • T to C, chromosome 13 at 81,750,249 bp
  • T to C, chromosome 14 at 50,126,754 bp
  • C to T, chromosome 15 at 23,367,008 bp
  • G to A, chromosome 16 at 94,762,679 bp
  • A to T, chromosome 17 at 89,200,596 bp
  • A to G, chromosome 19 at 3,936,373 bp
  • C to T, chromosome 19 at 31,920,894 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2435 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040396-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.