Strain Name:
C57BL/6J-MtgxR2443Btlr/Mmmh
Stock Number:
040401-MU
Citation ID:
RRID:MMRRC_040401-MU
Other Names:
R2443 (G1), C57BL/6J-MtgxR2443Btlr
Major Collection:

Gene Information

Fga
Name: fibrinogen alpha chain
Synonyms: Fib, ENSMUSG00000059807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14161
HGNC: HGNC:3661
Homologene: 428
Vcp
Name: valosin containing protein
Synonyms: AAA ATPase p97, p97, CDC48, p97/VCP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269523
Homologene: 5168
Vcan
Name: versican
Synonyms: Cspg2, hdf, PG-M, heart defect, 5430420N07Rik, DPEAAE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Myo1e
Name: myosin IE
Synonyms: 9130023P14Rik, 2310020N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Npy5r
Name: neuropeptide Y receptor Y5
Synonyms: Y5R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18168
HGNC: HGNC:7958
Homologene: 21241
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap1b, MAP5, Mtap-5, Mtap5, LC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Tkfc
Name: triokinase, FMN cyclase
Synonyms: Dak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225913
VEGA: 19
Homologene: 56710
Psmd12
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Synonyms: P55, 1500002F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66997
HGNC: HGNC:9557
Homologene: 2109
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14897
Homologene: 44226
Dlx2
Name: distal-less homeobox 2
Synonyms: Tes-1, DII A, Dlx-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13392
HGNC: HGNC:2915
Homologene: 3244
Strn3
Name: striatin, calmodulin binding protein 3
Synonyms: SG2NA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94186
VEGA: 12
Homologene: 82078
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: hensin, CRP-[b], CRP-[a], vomeroglandin, MUCLIN, ebnerin, gp300, Crpd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Elapor1
Name: endosome-lysosome associated apoptosis and autophagy regulator 1
Synonyms: 5330417C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229722
Homologene: 23249
Ms4a6d
Name: membrane-spanning 4-domains, subfamily A, member 6D
Synonyms: Ms4a11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68774
Homologene: 130755
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Asxl3
Name: additional sex combs like 3, transcriptional regulator
Synonyms: LOC381127, D430002O22Rik, D930044O18Rik, C230079D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211961
Homologene: 19371
Tmprss2
Name: transmembrane protease, serine 2
Synonyms: epitheliasin, D16Ertd61e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50528
VEGA: 16
Homologene: 4136
Clec4d
Name: C-type lectin domain family 4, member d
Synonyms: Mpcl, mcl, Clecsf8, mMCL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17474
Homologene: 7844
Myo7a
Name: myosin VIIA
Synonyms: nmf371, Hdb, Myo7, polka, USH1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231125
Homologene: 15119
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
Vmn1r33
Name: vomeronasal 1 receptor 33
Synonyms: V1rc14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171187
Homologene: 110800
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192193
Homologene: 33836
Oas3
Name: 2'-5' oligoadenylate synthetase 3
Synonyms: 2'-5' oligoadenylate synthetase-like 10, Oasl10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 246727
HGNC: HGNC:8088
Homologene: 4510
4932425I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83561
Homologene: 12850
Krt78
Name: keratin 78
Synonyms: 2310030B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 332131
VEGA: 15
Homologene: 65261
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Masp1
Name: mannan-binding lectin serine peptidase 1
Synonyms: Crarf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
Sla2
Name: Src-like-adaptor 2
Synonyms: A930009E21Rik, SLAP-2, SLAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77799
Homologene: 49989
Kif26b
Name: kinesin family member 26B
Synonyms: D230039L06Rik, N-11 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269152
Homologene: 18623
Mmp19
Name: matrix metallopeptidase 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 58223
VEGA: 10
HGNC: HGNC:7165
Homologene: 1820
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 319217
Homologene: 129754
Kcnip3
Name: Kv channel interacting protein 3, calsenilin
Synonyms: R74849, DREAM, Csen, 4933407H12Rik, KChIP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56461
Homologene: 8382
Pnpla2
Name: patatin-like phospholipase domain containing 2
Synonyms: desnutrin, 1110001C14Rik, 0610039C21Rik, Atgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66853
Homologene: 10687
Dync2li1
Name: dynein cytoplasmic 2 light intermediate chain 1
Synonyms: CGI-60, LIC3, D2lic, mD2LIC, 4933404O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213575
VEGA: 17
Homologene: 9336
Fez1
Name: fasciculation and elongation protein zeta 1 (zygin I)
Synonyms: UNC76, UNC-76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Zfp61
Name: zinc finger protein 61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22719
Homologene: 74923
Vmn1r232
Name: vomeronasal 1 receptor 232
Synonyms: V1re4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171227
Homologene: 121611
Tollip
Name: toll interacting protein
Synonyms: 4930403G24Rik, 4931428G15Rik, Toll interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54473
Homologene: 10375
Olfr1157
Name: olfactory receptor 1157
Synonyms: MOR174-1, GA_x6K02T2Q125-49446395-49445457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258846
HGNC: HGNC:8350
Homologene: 17402
Methig1
Name: methyltransferase hypoxia inducible domain containing 1
Synonyms: Mettl7a2Higd1c, UbiE-YGHL1, UbiE2-Hig1-4, AB099516, Mettl7a2-Higd1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 554292
Homologene: 128515
Dennd11
Name: DENN domain containing 11
Synonyms: E330009J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243780
Homologene: 82355
Anapc13
Name: anaphase promoting complex subunit 13
Synonyms: 1810004D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69010
Homologene: 32258
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 84,730,524 bp
  • C to A, chromosome 1 at 150,599,032 bp
  • A to C, chromosome 1 at 178,915,014 bp
  • A to G, chromosome 2 at 71,546,005 bp
  • A to T, chromosome 2 at 87,962,865 bp
  • T to A, chromosome 2 at 127,460,063 bp
  • G to A, chromosome 2 at 156,875,942 bp
  • A to G, chromosome 3 at 64,715,755 bp
  • A to G, chromosome 3 at 83,028,541 bp
  • A to T, chromosome 3 at 108,481,349 bp
  • A to T, chromosome 4 at 42,983,385 bp
  • A to G, chromosome 5 at 34,216,894 bp
  • C to A, chromosome 5 at 120,777,488 bp
  • T to C, chromosome 6 at 40,406,776 bp
  • A to T, chromosome 6 at 66,611,973 bp
  • T to C, chromosome 6 at 91,259,711 bp
  • A to T, chromosome 6 at 108,851,269 bp
  • G to A, chromosome 6 at 123,268,117 bp
  • A to G, chromosome 7 at 24,291,769 bp
  • G to A, chromosome 7 at 98,095,769 bp
  • T to C, chromosome 7 at 131,032,154 bp
  • T to C, chromosome 7 at 141,458,069 bp
  • C to T, chromosome 7 at 141,890,823 bp
  • T to A, chromosome 8 at 66,681,290 bp
  • T to A, chromosome 8 at 109,623,815 bp
  • T to A, chromosome 9 at 36,870,468 bp
  • C to T, chromosome 9 at 70,327,172 bp
  • C to T, chromosome 9 at 102,634,023 bp
  • A to G, chromosome 10 at 128,798,856 bp
  • T to A, chromosome 11 at 107,495,737 bp
  • A to T, chromosome 12 at 51,627,835 bp
  • C to A, chromosome 12 at 87,133,380 bp
  • T to G, chromosome 12 at 110,896,325 bp
  • A to G, chromosome 13 at 89,704,675 bp
  • T to C, chromosome 13 at 99,430,411 bp
  • T to C, chromosome 15 at 100,353,211 bp
  • C to T, chromosome 15 at 101,946,598 bp
  • A to T, chromosome 16 at 23,476,312 bp
  • A to G, chromosome 16 at 38,302,732 bp
  • T to G, chromosome 16 at 97,568,503 bp
  • A to G, chromosome 17 at 20,913,384 bp
  • C to A, chromosome 17 at 84,647,665 bp
  • T to A, chromosome 18 at 22,411,539 bp
  • A to G, chromosome 19 at 10,594,538 bp
  • G to A, chromosome 19 at 11,590,193 bp
  • C to T, chromosome 19 at 56,841,354 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2443 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040401-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.