Strain Name:
C57BL/6J-MtgxR2655Btlr/Mmmh
Stock Number:
040430-MU
Citation ID:
RRID:MMRRC_040430-MU
Other Names:
R2655 (G1), C57BL/6J-MtgxR2655Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: PC1, PC-1, polycystin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Syt4
Name: synaptotagmin IV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20983
VEGA: 18
Homologene: 7559
Stx12
Name: syntaxin 12
Synonyms: syntaxin 13, Stx13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100226
Homologene: 128192
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12695
Homologene: 72199
Nr2c2
Name: nuclear receptor subfamily 2, group C, member 2
Synonyms: TAK1, Tr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22026
HGNC: HGNC:7972
Homologene: 2475
Slu7
Name: SLU7 splicing factor homolog (S. cerevisiae)
Synonyms: D3Bwg0878e, D11Ertd730e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 193116
Homologene: 4690
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKbeta, MLTKalpha, Zak, B230120H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 65964
Homologene: 32331
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, b2b1200.1Clo, Drad-1, E130320P19Rik, E030015M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20563
Homologene: 3516
Bbs9
Name: Bardet-Biedl syndrome 9 (human)
Synonyms: EST 3159894, E130103I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319845
Homologene: 44480
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, GAPIII activator 3, hlb381, GAPIII, Ras GTPase-activating protein III, scat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 19414
Homologene: 7217
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239337
VEGA: 15
Homologene: 12808
Reck
Name: reversion-inducing-cysteine-rich protein with kazal motifs
Synonyms: St15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 53614
Homologene: 9622
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: E430013P11Rik, NRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241274
Homologene: 62431
Cat
Name: catalase
Synonyms: Cs-1, Cas1, Cas-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12359
HGNC: HGNC:1516
Homologene: 55514
Ttll7
Name: tubulin tyrosine ligase-like family, member 7
Synonyms: 1110049N09Rik, 4921517B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70892
Homologene: 41578
Ipcef1
Name: interaction protein for cytohesin exchange factors 1
Synonyms: A130090K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 320495
Homologene: 32271
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, b2b1000Clo, LTBP-1, Ltbp1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Olfr955
Name: olfactory receptor 955
Synonyms: GA_x6K02T2PVTD-33167297-33166353, MOR171-34, MOR171-50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258242
VEGA: 9
Homologene: 133698
Junb
Name: jun B proto-oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16477
HGNC: HGNC:6205
Homologene: 7390
Ttc25
Name: tetratricopeptide repeat domain 25
Synonyms: 4933404O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74407
Homologene: 12860
Rfx6
Name: regulatory factor X, 6
Synonyms: Rfxdc1, 4930572O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 320995
Homologene: 18318
Eif2b1
Name: eukaryotic translation initiation factor 2B, subunit 1 (alpha)
Synonyms: EIF2B, EIF2BA, 26kDa, D5Ertd406e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 209354
HGNC: HGNC:3257
Homologene: 1080
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: Vmn2r72-ps, EG244114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244114
Homologene: 115466
Chaf1b
Name: chromatin assembly factor 1, subunit B (p60)
Synonyms: CAF-IP60, MPHOSPH7, 2600017H24Rik, CAF-I 60 kDa subunit, CAF1, CAF1A, CAF1P60, CAF-1 subunit B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Cav1
Name: caveolin 1, caveolae protein
Synonyms: Cav-1, caveolin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12389
HGNC: HGNC:1527
Homologene: 1330
Vwa5b1
Name: von Willebrand factor A domain containing 5B1
Synonyms: 4931403E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75718
Homologene: 19431
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Tpte
Name: transmembrane phosphatase with tensin homology
Synonyms: Pten2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234129
Homologene: 50411
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: dwg, CD224, Ggtp, GGT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14598
HGNC: HGNC:4250
Homologene: 68450
Olfr642
Name: olfactory receptor 642
Synonyms: MOR13-6, GA_x6K02T2PBJ9-6784380-6783436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258326
Homologene: 17196
Mdfic
Name: MyoD family inhibitor domain containing
Synonyms: Kdt1, clone 1.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16543
Homologene: 18404
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: HUR7, headpin, PI13, HURPIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Cep112
Name: centrosomal protein 112
Synonyms: 1700029K01Rik, 8430407H02Rik, Macoco, 1700001M19Rik, Ccdc46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 76380
Homologene: 44915
Acot5
Name: acyl-CoA thioesterase 5
Synonyms: PTE-Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217698
Homologene: 77351
Casp4
Name: caspase 4, apoptosis-related cysteine peptidase
Synonyms: ich-3, Casp11, Caspase-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12363
HGNC: HGNC:1505
Homologene: 136493
Vmn1r211
Name: vomeronasal 1 receptor 211
Synonyms: V1rh20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 171277
Homologene: 110880
Epor
Name: erythropoietin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13857
VEGA: 9
HGNC: HGNC:3416
Homologene: 95
Igfbpl1
Name: insulin-like growth factor binding protein-like 1
Synonyms: 2810453O06Rik, 2810011G06Rik, IGFBP-like protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75426
Homologene: 10292
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 107,000,427 bp
  • A to G, chromosome 2 at 25,052,318 bp
  • A to G, chromosome 2 at 30,402,691 bp
  • C to A, chromosome 2 at 72,433,420 bp
  • T to C, chromosome 2 at 103,471,846 bp
  • A to G, chromosome 3 at 146,947,621 bp
  • T to A, chromosome 4 at 43,938,966 bp
  • T to C, chromosome 4 at 45,816,289 bp
  • T to C, chromosome 4 at 98,437,450 bp
  • C to A, chromosome 4 at 132,857,395 bp
  • C to T, chromosome 4 at 138,594,303 bp
  • G to A, chromosome 5 at 48,189,575 bp
  • A to G, chromosome 5 at 124,576,854 bp
  • T to C, chromosome 6 at 15,731,754 bp
  • A to G, chromosome 6 at 17,339,360 bp
  • C to T, chromosome 6 at 92,163,138 bp
  • A to G, chromosome 7 at 15,975,194 bp
  • T to C, chromosome 7 at 85,751,269 bp
  • T to C, chromosome 7 at 104,049,431 bp
  • T to C, chromosome 8 at 13,595,373 bp
  • A to G, chromosome 8 at 22,311,278 bp
  • A to G, chromosome 8 at 84,977,508 bp
  • C to A, chromosome 9 at 5,322,894 bp
  • A to G, chromosome 9 at 21,960,720 bp
  • G to A, chromosome 9 at 22,504,052 bp
  • A to T, chromosome 9 at 39,470,628 bp
  • T to C, chromosome 10 at 6,979,657 bp
  • A to G, chromosome 10 at 51,693,777 bp
  • T to A, chromosome 10 at 75,581,385 bp
  • A to G, chromosome 11 at 43,440,648 bp
  • T to A, chromosome 11 at 100,553,579 bp
  • T to C, chromosome 11 at 108,437,201 bp
  • T to C, chromosome 12 at 75,114,540 bp
  • T to A, chromosome 12 at 84,075,876 bp
  • A to G, chromosome 13 at 22,852,416 bp
  • A to T, chromosome 15 at 11,065,088 bp
  • T to C, chromosome 16 at 93,891,511 bp
  • T to C, chromosome 17 at 24,576,490 bp
  • G to A, chromosome 17 at 75,005,983 bp
  • A to T, chromosome 18 at 31,443,544 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2655 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040430-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.