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Strain Name:
C57BL/6J-MtgxR2697Btlr/Mmmh
Stock Number:
040435-MU
Citation ID:
RRID:MMRRC_040435-MU
Other Names:
R2697 (G1), C57BL/6J-MtgxR2697Btlr
Major Collection:

Strain Information

Crhr2
Name: corticotropin releasing hormone receptor 2
Synonyms: Crfr2, CRF-R2, CRFR2beta, CRFR2alpha, CRF 2 receptor, CRH-R2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12922
HGNC: HGNC:2358
Homologene: 55612
Cradd
Name: CASP2 and RIPK1 domain containing adaptor with death domain
Synonyms: RAIDD
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12905
VEGA: 10
HGNC: HGNC:2340
Homologene: 2821
U2af2
Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22185
Homologene: 110853
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: Rsk3, Rps6ka-rs1, 90kDa, p90rsk, pp90rsk, D17Wsu134e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Gars1
Name: glycyl-tRNA synthetase 1
Synonyms: Sgrp23, GENA202, Gena201, Gars
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353172
HGNC: HGNC:4162
Homologene: 1547
Kif11
Name: kinesin family member 11
Synonyms: Eg5, Knsl1, Kifl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226747
Homologene: 9142
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 21,479,432 bp
  • T to C, chromosome 1 at 51,863,358 bp
  • A to T, chromosome 1 at 173,567,276 bp
  • T to C, chromosome 1 at 179,752,532 bp
  • T to C, chromosome 2 at 19,303,935 bp
  • T to C, chromosome 2 at 35,032,091 bp
  • T to C, chromosome 2 at 110,794,960 bp
  • C to T, chromosome 3 at 138,983,721 bp
  • A to C, chromosome 3 at 151,510,623 bp
  • T to C, chromosome 4 at 108,695,819 bp
  • A to G, chromosome 4 at 119,247,180 bp
  • C to A, chromosome 5 at 35,280,698 bp
  • A to G, chromosome 5 at 45,553,224 bp
  • T to A, chromosome 5 at 69,541,140 bp
  • T to C, chromosome 5 at 87,578,538 bp
  • T to C, chromosome 5 at 104,064,993 bp
  • A to G, chromosome 5 at 114,355,213 bp
  • A to G, chromosome 6 at 5,232,429 bp
  • A to T, chromosome 6 at 43,236,126 bp
  • A to T, chromosome 6 at 55,061,065 bp
  • A to G, chromosome 6 at 55,102,830 bp
  • T to A, chromosome 6 at 67,535,219 bp
  • T to A, chromosome 6 at 82,492,597 bp
  • C to A, chromosome 6 at 90,642,320 bp
  • A to G, chromosome 6 at 91,479,929 bp
  • T to C, chromosome 6 at 132,626,656 bp
  • G to A, chromosome 7 at 5,067,546 bp
  • T to A, chromosome 7 at 125,643,954 bp
  • T to C, chromosome 9 at 65,452,021 bp
  • T to C, chromosome 9 at 75,242,882 bp
  • T to C, chromosome 9 at 85,324,740 bp
  • A to G, chromosome 10 at 95,175,945 bp
  • G to A, chromosome 10 at 129,767,924 bp
  • A to T, chromosome 11 at 3,863,407 bp
  • C to T, chromosome 11 at 4,738,837 bp
  • T to C, chromosome 11 at 5,534,888 bp
  • A to G, chromosome 11 at 60,855,696 bp
  • T to C, chromosome 11 at 65,955,626 bp
  • T to A, chromosome 11 at 84,364,413 bp
  • C to A, chromosome 11 at 120,784,039 bp
  • G to A, chromosome 13 at 67,491,005 bp
  • C to T, chromosome 14 at 33,956,018 bp
  • C to T, chromosome 14 at 50,533,781 bp
  • A to T, chromosome 14 at 68,514,783 bp
  • T to C, chromosome 15 at 76,599,329 bp
  • T to A, chromosome 15 at 101,846,929 bp
  • T to G, chromosome 16 at 37,042,153 bp
  • A to G, chromosome 16 at 62,801,802 bp
  • T to C, chromosome 16 at 89,793,164 bp
  • A to G, chromosome 17 at 6,299,353 bp
  • T to G, chromosome 17 at 7,300,322 bp
  • A to T, chromosome 17 at 29,376,921 bp
  • G to A, chromosome 17 at 32,820,240 bp
  • A to G, chromosome 17 at 38,131,009 bp
  • T to A, chromosome 17 at 86,115,311 bp
  • G to T, chromosome 18 at 7,088,570 bp
  • C to T, chromosome 18 at 53,740,125 bp
  • T to C, chromosome 18 at 74,273,617 bp
  • T to C, chromosome 19 at 7,196,792 bp
  • T to A, chromosome 19 at 37,411,615 bp
  • T to A, chromosome 19 at 41,584,027 bp
  • C to T, chromosome 19 at 55,083,209 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2697 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040435-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.