Strain Name:
C57BL/6J-MtgxR2851Btlr/Mmmh
Stock Number:
040444-MU
Citation ID:
RRID:MMRRC_040444-MU
Other Names:
R2851 (G1), C57BL/6J-MtgxR2851Btlr
Major Collection:

Strain Information

Ednrb
Name: endothelin receptor type B
Synonyms: ETb, Sox10m1, ETR-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Pias3
Name: protein inhibitor of activated STAT 3
Synonyms: Pias3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229615
Homologene: 4447
Cmtm5
Name: CKLF-like MARVEL transmembrane domain containing 5
Synonyms: 2900052H21Rik, 1500005P16Rik, Cklfsf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67272
VEGA: 14
Homologene: 16322
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20321
Homologene: 40653
Tmprss12
Name: transmembrane (C-terminal) protease, serine 12
Synonyms: 4930478A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75002
VEGA: 15
Homologene: 16598
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: LKB1IP, LIP1, 1200014D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71728
Homologene: 12406
Ppa2
Name: pyrophosphatase (inorganic) 2
Synonyms: Sid6306, 1110013G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74776
Homologene: 134244
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 277854
Homologene: 34718
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Proser1
Name: proline and serine rich 1
Synonyms: 2810046L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 212127
Homologene: 13463
Mdc1
Name: mediator of DNA damage checkpoint 1
Synonyms: NFBD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240087
Homologene: 67092
Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13078
VEGA: 17
HGNC: HGNC:2597
Homologene: 68035
Srprb
Name: signal recognition particle receptor, B subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20818
Homologene: 6332
Cyp51
Name: cytochrome P450, family 51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13121
HGNC: HGNC:2649
Homologene: 55488
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233064
Homologene: 15927
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsp, Tsbp, Sh2bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22083
Homologene: 40668
Tmeff1
Name: transmembrane protein with EGF-like and two follistatin-like domains 1
Synonyms: tomoregulin-like, M7365
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230157
Homologene: 130458
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, D230004I22Rik, 2600013A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268902
Homologene: 43188
Hspd1
Name: heat shock protein 1 (chaperonin)
Synonyms: Hsp60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15510
HGNC: HGNC:5261
Homologene: 1626
Crispld2
Name: cysteine-rich secretory protein LCCL domain containing 2
Synonyms: 1810049K24Rik, coffeecrisp, Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78892
Homologene: 41792
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: TIF2/GRIP-1, Grip1, D1Ertd433e, glucocorticoid receptor-interacting protein 1, TIF2, TIF-2, SRC-2, KAT13C, bHLHe75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213773
Homologene: 4711
Zfp653
Name: zinc finger protein 653
Synonyms: E430039K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319601
VEGA: 9
Homologene: 16346
Nceh1
Name: neutral cholesterol ester hydrolase 1
Synonyms: CPO-BP, mKIAA1363, B230106I24Rik, Aadacl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320024
Homologene: 23251
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Hyk, Tie2, Cd202b, tie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21687
Homologene: 397
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231125
Homologene: 15119
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213262
Homologene: 10584
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Itga9
Name: integrin alpha 9
Synonyms: 2610002H11Rik, D9Ertd428e, 6720458D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Pilra
Name: paired immunoglobin-like type 2 receptor alpha
Synonyms: FDF03
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231805
Homologene: 8387
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17535
HGNC: HGNC:7230
Homologene: 4083
Npsr1
Name: neuropeptide S receptor 1
Synonyms: PGR14, VRR1, 9330128H10Rik, Gpr154
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319239
Homologene: 45515
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
E230016K23Rik
Name: RIKEN cDNA E230016K23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100504464
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242584
Homologene: 11702
Mthfsd
Name: methenyltetrahydrofolate synthetase domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234814
Homologene: 11245
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625068
Homologene: 129606
Ndufb5
Name: NADH:ubiquinone oxidoreductase subunit B5
Synonyms: 0610007D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66046
HGNC: HGNC:7700
Homologene: 31093
Arhgef4
Name: Rho guanine nucleotide exchange factor (GEF) 4
Synonyms: 9330140K16Rik, Asef, C230030N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Als2cl
Name: ALS2 C-terminal like
Synonyms: mRn.49018, D930044G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235633
Homologene: 17152
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, gp115, EMILIN-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100952
Homologene: 5117
Gmcl1
Name: germ cell-less, spermatogenesis associated 1
Synonyms: mglc-1, 2810049L19Rik, Gcl, Btbd13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23885
Homologene: 8021
Bank1
Name: B cell scaffold protein with ankyrin repeats 1
Synonyms: A530094C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242248
Homologene: 9926
Pdzd7
Name: PDZ domain containing 7
Synonyms: Pdzk7, EG435601
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100503041
Homologene: 129509
Krt82
Name: keratin 82
Synonyms: Krt2-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 114566
VEGA: 15
HGNC: HGNC:6459
Homologene: 13200
Zkscan16
Name: zinc finger with KRAB and SCAN domains 16
Synonyms: Zfp483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041581
Homologene: 26419
Dzip1
Name: DAZ interacting protein 1
Synonyms: 2510025K24Rik, 2810422M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66573
VEGA: 14
Homologene: 45708
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: 4933402B14Rik, Gm6095, 4921529N20Rik, Tmem146
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Spata1
Name: spermatogenesis associated 1
Synonyms: 4921536I21Rik, SP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70951
Homologene: 23356
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240427
Homologene: 9192
Il19
Name: interleukin 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329244
HGNC: HGNC:5990
Homologene: 17813
Ceacam11
Name: CEA cell adhesion molecule 11
Synonyms: 1600015D01Rik, Ceacam11-C4, Ceacam11-C3, Ceacam11-C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66996
Homologene: 135962
Mfsd4b2
Name: major facilitator superfamily domain containing 4B2
Synonyms: 2010001E11Rik, Mfsd4b2-ps, Mfsd4b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72045
Homologene: 129931
Gpr62
Name: G protein-coupled receptor 62
Synonyms: 4933402E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 436090
Homologene: 50962
Timm22
Name: translocase of inner mitochondrial membrane 22
Synonyms: 2610511O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56322
Homologene: 32173
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 13,186,889 bp
  • T to C, chromosome 1 at 20,058,302 bp
  • A to C, chromosome 1 at 34,724,048 bp
  • T to A, chromosome 1 at 40,000,755 bp
  • A to T, chromosome 1 at 55,081,097 bp
  • A to G, chromosome 1 at 75,529,267 bp
  • A to G, chromosome 1 at 130,935,957 bp
  • A to G, chromosome 3 at 27,241,355 bp
  • T to C, chromosome 3 at 32,746,451 bp
  • G to A, chromosome 3 at 53,480,545 bp
  • T to A, chromosome 3 at 76,429,738 bp
  • A to G, chromosome 3 at 96,703,537 bp
  • A to G, chromosome 3 at 116,885,129 bp
  • A to T, chromosome 3 at 133,321,003 bp
  • A to T, chromosome 3 at 136,242,940 bp
  • A to G, chromosome 3 at 146,487,540 bp
  • T to A, chromosome 4 at 48,604,692 bp
  • A to G, chromosome 4 at 58,957,364 bp
  • A to G, chromosome 4 at 94,820,224 bp
  • A to G, chromosome 4 at 103,096,661 bp
  • A to T, chromosome 5 at 4,099,183 bp
  • A to G, chromosome 5 at 30,917,165 bp
  • A to G, chromosome 5 at 32,924,171 bp
  • G to A, chromosome 5 at 34,196,662 bp
  • T to A, chromosome 5 at 137,836,080 bp
  • A to C, chromosome 6 at 86,726,177 bp
  • T to C, chromosome 7 at 17,978,526 bp
  • A to T, chromosome 7 at 30,261,437 bp
  • C to T, chromosome 7 at 111,053,446 bp
  • T to A, chromosome 7 at 128,204,560 bp
  • T to A, chromosome 8 at 120,014,089 bp
  • G to A, chromosome 8 at 121,105,773 bp
  • A to G, chromosome 9 at 14,826,547 bp
  • A to T, chromosome 9 at 22,057,566 bp
  • A to G, chromosome 9 at 24,310,005 bp
  • CGG to CG, chromosome 9 at 37,411,490 bp
  • A to T, chromosome 9 at 79,678,332 bp
  • A to G, chromosome 9 at 95,500,682 bp
  • G to A, chromosome 9 at 103,198,839 bp
  • T to C, chromosome 9 at 106,464,712 bp
  • T to C, chromosome 9 at 110,894,135 bp
  • G to A, chromosome 9 at 118,636,536 bp
  • T to A, chromosome 10 at 39,922,123 bp
  • T to A, chromosome 10 at 130,394,167 bp
  • C to A, chromosome 11 at 59,030,018 bp
  • G to A, chromosome 11 at 76,414,099 bp
  • G to A, chromosome 11 at 83,622,532 bp
  • A to G, chromosome 14 at 54,938,055 bp
  • A to T, chromosome 14 at 103,144,333 bp
  • G to T, chromosome 14 at 103,821,674 bp
  • A to C, chromosome 14 at 118,922,445 bp
  • C to A, chromosome 15 at 100,282,415 bp
  • T to C, chromosome 15 at 101,548,435 bp
  • A to G, chromosome 16 at 73,961,888 bp
  • T to C, chromosome 16 at 96,622,715 bp
  • T to C, chromosome 17 at 24,702,583 bp
  • T to A, chromosome 17 at 35,849,010 bp
  • A to G, chromosome 17 at 56,660,169 bp
  • T to C, chromosome 17 at 79,710,220 bp
  • T to A, chromosome 18 at 78,923,996 bp
  • C to G, chromosome 19 at 45,027,674 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2851 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040444-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.