Strain Name:
C57BL/6J-MtgxR2866Btlr/Mmmh
Stock Number:
040455-MU
Citation ID:
RRID:MMRRC_040455-MU
Other Names:
R2866 (G1), C57BL/6J-MtgxR2866Btlr
Major Collection:

Gene Information

Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11287
Homologene: 104112
Lcat
Name: lecithin cholesterol acyltransferase
Synonyms: D8Wsu61e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16816
HGNC: HGNC:6522
Homologene: 68042
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 170750
Homologene: 6424
Ucp2
Name: uncoupling protein 2 (mitochondrial, proton carrier)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22228
Homologene: 2516
Prkci
Name: protein kinase C, iota
Synonyms: Pkcl, Pkci, 2310021H13Rik, Prkcl, aPKClambda, PKClambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18759
HGNC: HGNC:9404
Homologene: 37667
Cstf1
Name: cleavage stimulation factor, 3' pre-RNA, subunit 1
Synonyms: 1700057K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67337
HGNC: HGNC:2483
Homologene: 1012
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, RAMP, MYM, FIM, Zfp198
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101861
Homologene: 69427
Gabpb2
Name: GA repeat binding protein, beta 2
Synonyms: 9430006E19Rik, Gabpb2-1, A430024B14Rik, 1810015F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213054
Homologene: 34921
Tead1
Name: TEA domain family member 1
Synonyms: mTEF-1, TEF-1, TEAD-1, Tcf13, Gtrgeo5, B230114H05Rik, 2610024B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21676
Homologene: 2418
Polr1has
Name: RNA polymerase I subunit H, antisense
Synonyms: 1700022C21Rik, Znrd1as
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76416
Homologene: 130062
Rab3ip
Name: RAB3A interacting protein
Synonyms: Gtpat12, SSX2 interacting protein, Rabin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216363
VEGA: 10
Homologene: 32340
Dennd1b
Name: DENN/MADD domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329260
Homologene: 11739
Lca5
Name: Leber congenital amaurosis 5 (human)
Synonyms: 5730406O13Rik, ORF64, 4930431B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75782
Homologene: 32718
Rab23
Name: RAB23, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19335
Homologene: 7503
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Nr2e1
Name: nuclear receptor subfamily 2, group E, member 1
Synonyms: Nr2e1, Tlx, Mtll, tailless
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21907
HGNC: HGNC:7973
Homologene: 37750
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: LOC381538, Gm1027, Heatr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381538
Homologene: 19633
Atmin
Name: ATM interactor
Synonyms: Asciz, gpg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234776
Homologene: 35321
Fhad1
Name: forkhead-associated (FHA) phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329977
Homologene: 77947
Ctss
Name: cathepsin S
Synonyms: Cat S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13040
HGNC: HGNC:2545
Homologene: 20867
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Olfr615
Name: olfactory receptor 615
Synonyms: GA_x6K02T2PBJ9-6284902-6285843, MOR19-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259084
Homologene: 17494
Dcaf11
Name: DDB1 and CUL4 associated factor 11
Synonyms: 0710008A13Rik, GLO14, D14Ucla1, Wdr23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 28199
Homologene: 11886
F830045P16Rik
Name: RIKEN cDNA F830045P16 gene
Synonyms: Sirpb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228592
Homologene: 136180
Clec2g
Name: C-type lectin domain family 2, member g
Synonyms: 4632413B12Rik, Ocilrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70809
Homologene: 136309
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo, mSlo1, Slo1, MaxiK, BK channel alpha subunit, 5730414M22Rik, BKCa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Olfr1564
Name: olfactory receptor 1564
Synonyms: Gm4461
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100043474
Homologene: 133726
Tigd4
Name: tigger transposable element derived 4
Synonyms: Tigd4, C130063O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 403175
Homologene: 131124
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: enteropeptidase, enterokinase, A130097D21Rik, Prss7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Olfr467
Name: olfactory receptor 467
Synonyms: GA_x6K02T2PBJ9-10144091-10145011, MOR204-33P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257919
Homologene: 81542
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Cyp2c23
Name: cytochrome P450, family 2, subfamily c, polypeptide 23
Synonyms: Cyp2c44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226143
Homologene: 115563
Cenpj
Name: centromere protein J
Synonyms: 4932437H03Rik, Sas4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219103
Homologene: 10204
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: 4632412N22Rik, Fam179a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320159
Homologene: 65315
Gfra1
Name: glial cell line derived neurotrophic factor family receptor alpha 1
Synonyms: GDNFR-alpha, GFR alpha-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14585
HGNC: HGNC:4243
Homologene: 3855
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Cpz
Name: carboxypeptidase Z
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242939
HGNC: HGNC:2333
Homologene: 2709
Muc21
Name: mucin 21
Synonyms: epiglycanin, Gm9573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 672682
Best1
Name: bestrophin 1
Synonyms: best macular dystrophy, mBest1, Vmd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 24115
Homologene: 37895
Usp17lb
Name: ubiquitin specific peptidase 17-like B
Synonyms: Dub1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381944
Homologene: 131315
Psg27
Name: pregnancy-specific glycoprotein 27
Synonyms: cea15, EG545925
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545925
Homologene: 110989
Erp27
Name: endoplasmic reticulum protein 27
Synonyms: 1810047B09Rik, 1810033M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69187
Homologene: 12303
Cyp2c68
Name: cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms: 9030012A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 433247
Homologene: 74936
FP885536.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210503
Homologene: 138402
Lat2
Name: linker for activation of T cells family, member 2
Synonyms: Wbscr15, Wbscr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56743
Homologene: 11297
Mapk10
Name: mitogen-activated protein kinase 10
Synonyms: p493F12, JNK3, Serk2, C230008H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26414
HGNC: HGNC:6872
Homologene: 56439
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: prostacyclin receptor, IP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Olfr1089
Name: olfactory receptor 1089
Synonyms: GA_x6K02T2Q125-48226321-48225386, MOR193-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257933
Homologene: 79354
Col8a2
Name: collagen, type VIII, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329941
HGNC: HGNC:2216
Homologene: 55879
Rilpl2
Name: Rab interacting lysosomal protein-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80291
Homologene: 12723
Gm16242
Name: predicted gene 16242
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Gm10323
Name: predicted gene 10323
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105245545
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 33,738,295 bp
  • A to G, chromosome 1 at 139,170,281 bp
  • A to T, chromosome 2 at 86,733,429 bp
  • C to T, chromosome 2 at 121,025,921 bp
  • A to G, chromosome 2 at 129,472,959 bp
  • A to T, chromosome 2 at 172,376,262 bp
  • T to C, chromosome 3 at 31,018,536 bp
  • A to G, chromosome 3 at 84,593,952 bp
  • T to C, chromosome 3 at 95,203,929 bp
  • A to G, chromosome 3 at 95,545,406 bp
  • C to T, chromosome 4 at 106,691,090 bp
  • A to G, chromosome 4 at 126,311,199 bp
  • A to G, chromosome 4 at 141,920,788 bp
  • T to A, chromosome 4 at 156,333,417 bp
  • T to C, chromosome 5 at 35,502,361 bp
  • C to T, chromosome 5 at 103,038,682 bp
  • T to C, chromosome 5 at 124,477,835 bp
  • T to A, chromosome 5 at 134,605,944 bp
  • A to G, chromosome 6 at 128,525,264 bp
  • T to C, chromosome 6 at 128,948,756 bp
  • T to A, chromosome 6 at 129,799,634 bp
  • A to G, chromosome 6 at 135,733,639 bp
  • A to G, chromosome 6 at 136,908,010 bp
  • A to G, chromosome 7 at 16,906,869 bp
  • T to A, chromosome 7 at 18,561,893 bp
  • A to G, chromosome 7 at 97,506,049 bp
  • T to C, chromosome 7 at 100,497,252 bp
  • A to T, chromosome 7 at 103,560,857 bp
  • T to C, chromosome 7 at 104,840,748 bp
  • T to A, chromosome 7 at 107,814,919 bp
  • A to G, chromosome 7 at 112,759,487 bp
  • C to T, chromosome 8 at 105,939,879 bp
  • T to A, chromosome 8 at 116,956,373 bp
  • A to G, chromosome 9 at 41,969,781 bp
  • A to T, chromosome 9 at 83,396,060 bp
  • A to G, chromosome 10 at 42,574,351 bp
  • A to T, chromosome 10 at 116,907,127 bp
  • T to C, chromosome 12 at 16,699,550 bp
  • C to A, chromosome 13 at 66,854,510 bp
  • A to T, chromosome 14 at 23,373,207 bp
  • A to T, chromosome 14 at 35,562,559 bp
  • A to T, chromosome 14 at 55,565,745 bp
  • T to C, chromosome 14 at 56,552,180 bp
  • T to A, chromosome 14 at 56,928,248 bp
  • T to A, chromosome 16 at 79,035,233 bp
  • A to T, chromosome 17 at 21,397,256 bp
  • T to A, chromosome 17 at 33,216,278 bp
  • T to C, chromosome 17 at 35,619,707 bp
  • A to T, chromosome 17 at 36,965,160 bp
  • T to C, chromosome 17 at 71,709,597 bp
  • T to C, chromosome 19 at 9,986,221 bp
  • T to C, chromosome 19 at 33,722,913 bp
  • A to G, chromosome 19 at 39,689,145 bp
  • T to C, chromosome 19 at 44,005,446 bp
  • T to C, chromosome 19 at 53,014,598 bp
  • C to T, chromosome 19 at 58,239,307 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2866 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040455-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.