Strain Name:
C57BL/6J-MtgxR2876Btlr/Mmmh
Stock Number:
040464-MU
Citation ID:
RRID:MMRRC_040464-MU
Other Names:
R2876 (G1), C57BL/6J-MtgxR2876Btlr
Major Collection:

Strain Information

Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112
Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Spidr
Name: scaffolding protein involved in DNA repair
Synonyms: 2310008H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224008
VEGA: 16
Homologene: 51693
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Adrm1
Name: adhesion regulating molecule 1 26S proteasome ubiquitin receptor
Synonyms: ARM-1, 2510006J17Rik, Gp110, 1110063P18Rik, Rpn13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56436
Homologene: 10513
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
Synonyms: PMCA1, E130111D10Rik, 2810442I22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67972
VEGA: 10
HGNC: HGNC:814
Homologene: 55597
Rad1
Name: RAD1 checkpoint DNA exonuclease
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19355
HGNC: HGNC:9806
Homologene: 37695
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: 2310047C21Rik, D8Wsu49e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71927
Homologene: 12423
Sdc4
Name: syndecan 4
Synonyms: ryudocan, Synd4, syndecan-4, S4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20971
Homologene: 31121
Rnft2
Name: ring finger protein, transmembrane 2
Synonyms: B830028P19Rik, Tmem118
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269695
Homologene: 41892
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 170721
Homologene: 71541
5730507C01Rik
Name: RIKEN cDNA 5730507C01 gene
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 236366
VEGA: 12
H2-T22
Name: histocompatibility 2, T region locus 22
Synonyms: H-2T22, H-2T17, H2-T17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15039
Homologene: 79525
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66661
Homologene: 38254
Afm
Name: afamin
Synonyms: Alf, alpha albumin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Ints11
Name: integrator complex subunit 11
Synonyms: 2410006F12Rik, Cpsf3l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71957
Homologene: 9894
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Or13n4
Name: olfactory receptor family 13 subfamily N member 4
Synonyms: GA_x6K02T2PBJ9-9202245-9201289, MOR260-4, Olfr702
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258590
Homologene: 121512
Adamts9
Name: ADAM metallopeptidase with thrombospondin type 1 motif 9
Synonyms: 1810011L16Rik, E030027K14Rik, 8430403M15Rik, Mhdaund4, Gsfund3, UND3, Mhdaund3, UND4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101401
Homologene: 18821
4932411E22Rik
Name: RIKEN cDNA 4932411E22 gene
Type: Gene
Species: Mouse
Chromosome: 11
Fam38b
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215772
Homologene: 100289
Slco1c1
Name: solute carrier organic anion transporter family, member 1c1
Synonyms: OATP-F, Slc21a14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58807
Homologene: 23008
Dennd4b
Name: DENN domain containing 4B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229541
Homologene: 28281
Vmn2r89
Name: vomeronasal 2, receptor 89
Synonyms: V2r11, V2r10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22301
Rhbdd1
Name: rhomboid domain containing 1
Synonyms: 4930418P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76867
Homologene: 12659
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 0610043A03Rik, 2210420P05Rik, 2600014C01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70297
Homologene: 45639
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99334
Homologene: 17586
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: MRP, Mdrap, Mrp1, Abcc1b, Abcc1a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Acot6
Name: acyl-CoA thioesterase 6
Synonyms: 4632408A20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217700
Homologene: 72506
Zbed6
Name: zinc finger, BED type containing 6
Synonyms: similar to Zinc finger BED domain containing protein 4, Gm8466, MGR, Gm38394
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 667118
Homologene: 130066
Ilvbl
Name: ilvB (bacterial acetolactate synthase)-like
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216136
VEGA: 10
HGNC: HGNC:6041
Homologene: 68532
Masp2
Name: MBL associated serine protease 2
Synonyms: MAp19, MASP-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17175
HGNC: HGNC:6902
Homologene: 4819
Pax5
Name: paired box 5
Synonyms: Pax-5, EBB-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18507
HGNC: HGNC:8619
Homologene: 56419
Or2ag18
Name: olfactory receptor family 2 subfamily AG member 18
Synonyms: GA_x6K02T2PBJ9-9184187-9183237, MOR283-4, Olfr700
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258593
Homologene: 64895
Ccdc152
Name: coiled-coil domain containing 152
Synonyms: ENSMUSG00000071814
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100039139
VEGA: 15
Homologene: 79247
Brox
Name: BRO1 domain and CAAX motif containing
Synonyms: 0610010K06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71678
Homologene: 13499
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433586
Homologene: 41284
Or5g26
Name: olfactory receptor family 5 subfamily G member 26
Synonyms: OR93, 912-93, Olfr4-3, GA_x6K02T2Q125-47143827-47142871, MOR175-1, Olfr154
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27216
Homologene: 104131
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,686,438 bp
  • A to G, chromosome 1 at 82,368,369 bp
  • C to T, chromosome 1 at 133,656,860 bp
  • A to G, chromosome 1 at 183,287,845 bp
  • A to G, chromosome 1 at 189,658,644 bp
  • T to A, chromosome 2 at 48,892,178 bp
  • A to C, chromosome 2 at 65,715,897 bp
  • A to G, chromosome 2 at 85,663,690 bp
  • T to C, chromosome 2 at 121,164,100 bp
  • T to C, chromosome 2 at 164,431,291 bp
  • A to G, chromosome 2 at 180,175,618 bp
  • G to A, chromosome 3 at 51,690,059 bp
  • T to C, chromosome 3 at 90,269,492 bp
  • A to G, chromosome 4 at 44,692,047 bp
  • T to A, chromosome 4 at 148,608,001 bp
  • C to A, chromosome 4 at 155,887,425 bp
  • T to A, chromosome 5 at 76,995,920 bp
  • T to C, chromosome 5 at 90,548,885 bp
  • G to A, chromosome 5 at 118,193,621 bp
  • T to C, chromosome 6 at 92,795,910 bp
  • T to C, chromosome 6 at 128,491,550 bp
  • T to C, chromosome 6 at 141,559,856 bp
  • C to G, chromosome 7 at 106,805,997 bp
  • A to T, chromosome 7 at 106,824,457 bp
  • T to C, chromosome 8 at 85,780,510 bp
  • T to G, chromosome 10 at 10,422,719 bp
  • A to G, chromosome 10 at 58,290,302 bp
  • A to T, chromosome 10 at 60,307,496 bp
  • C to A, chromosome 10 at 78,583,056 bp
  • A to G, chromosome 10 at 98,999,745 bp
  • A to G, chromosome 11 at 89,391,636 bp
  • A to C, chromosome 12 at 11,242,068 bp
  • C to A, chromosome 12 at 18,533,643 bp
  • T to A, chromosome 12 at 83,778,927 bp
  • T to G, chromosome 12 at 84,101,262 bp
  • T to A, chromosome 13 at 89,704,237 bp
  • G to T, chromosome 14 at 51,455,084 bp
  • T to C, chromosome 15 at 3,298,181 bp
  • T to C, chromosome 15 at 10,490,331 bp
  • A to T, chromosome 16 at 14,457,960 bp
  • A to T, chromosome 16 at 15,912,589 bp
  • A to G, chromosome 16 at 17,367,550 bp
  • A to G, chromosome 17 at 36,038,970 bp
  • A to G, chromosome 18 at 63,053,035 bp
  • A to G, chromosome 19 at 16,655,847 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2876 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040464-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.