Strain Name:
C57BL/6J-MtgxR2879Btlr/Mmmh
Stock Number:
040467-MU
Citation ID:
RRID:MMRRC_040467-MU
Other Names:
R2879 (G1), C57BL/6J-MtgxR2879Btlr
Major Collection:

Strain Information

Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191
Plg
Name: plasminogen
Synonyms: Pg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18815
VEGA: 17
Homologene: 55452
Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Tmem121
Name: transmembrane protein 121
Synonyms: Hole, 2410008J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69195
Homologene: 11900
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Smad1
Name: SMAD family member 1
Synonyms: Madr1, Smad 1, Madh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17125
HGNC: HGNC:6767
Homologene: 21196
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243272
Homologene: 10055
Mrps27
Name: mitochondrial ribosomal protein S27
Synonyms: 2610028H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218506
VEGA: 13
Homologene: 41006
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Fxr1
Name: FMR1 autosomal homolog 1
Synonyms: 1110050J02Rik, 9530073J07Rik, Fxr1p, Fxr1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22019
Homologene: 2471
Chaf1a
Name: chromatin assembly factor 1, subunit A (p150)
Synonyms: CAF-1, p150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 27221
VEGA: 17
HGNC: HGNC:1910
Homologene: 4003
Tfcp2
Name: transcription factor CP2
Synonyms: LBP-1d, LBP-1c, LSF, UBP-1, CP-2, D230015P20Rik, LBP1, CP2, Tcfcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21422
VEGA: 15
Homologene: 4134
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Wipf2
Name: WAS/WASL interacting protein family, member 2
Synonyms: 1110014J05Rik, 5730509C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68524
Homologene: 15777
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: mGluR7, Gpr1g, E130018M02Rik, 6330570A01Rik, mGlu7a receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, 2610524E03Rik, YR-23, D1Bwg0491e, Neg, Rw1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56030
Homologene: 32428
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, 1110067M05Rik, Thrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327987
Homologene: 21067
Abca17
Name: ATP-binding cassette, sub-family A (ABC1), member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381072
Homologene: 86807
Pnkp
Name: polynucleotide kinase 3'- phosphatase
Synonyms: PNK, 1810009G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 59047
HGNC: HGNC:9154
Homologene: 5247
Ibsp
Name: integrin binding sialoprotein
Synonyms: BSP, bone sialoprotein, Bsp2, Bsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15891
HGNC: HGNC:5341
Homologene: 3644
Lnx1
Name: ligand of numb-protein X 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16924
HGNC: HGNC:6657
Homologene: 7819
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Zfp346
Name: zinc finger protein 346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26919
Homologene: 8073
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Chchd4
Name: coiled-coil-helix-coiled-coil-helix domain containing 4
Synonyms: 2410012P20Rik, 2810014D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72170
Homologene: 14846
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ttpal
Name: tocopherol (alpha) transfer protein-like
Synonyms: 3110080A02Rik, 5830472M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76080
Homologene: 41562
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50791
Homologene: 8189
Cyp2b13
Name: cytochrome P450, family 2, subfamily b, polypeptide 13
Synonyms: phenobarbital inducible, type c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13089
HGNC: HGNC:2615
Homologene: 74933
Or1p1c
Name: olfactory receptor family 1 subfamily P member 1C
Synonyms: GA_x6K02T2P1NL-4415162-4416133, MOR133-1, Olfr406-ps, Olfr406
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258181
HGNC: HGNC:8222
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Fer1l4
Name: fer-1-like 4 (C. elegans)
Synonyms: 9130402C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74562
Homologene: 19075
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19886
Homologene: 2207
Arhgef10l
Name: Rho guanine nucleotide exchange factor (GEF) 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72754
Homologene: 10017
Myo1c
Name: myosin IC
Synonyms: myosin-Ibeta, myr2, C80397, mm1beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Fbxo2
Name: F-box protein 2
Synonyms: NFB42, FBX2, Fbs1, Prpl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230904
Homologene: 8132
Txlnb
Name: taxilin beta
Synonyms: Mdp77, 2310001N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 378431
Homologene: 44534
Ssc5d
Name: scavenger receptor cysteine rich family, 5 domains
Synonyms: s5d-srcrb, A430110N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269855
Homologene: 77555
Acte1
Name: actin, epsilon 1
Synonyms: LOC244239, Gm498
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102636989
Homologene: 131918
Prodh
Name: proline dehydrogenase
Synonyms: Pro-1, Pro1, Ym24d07
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19125
HGNC: HGNC:9453
Homologene: 40764
Car5a
Name: carbonic anhydrase 5a, mitochondrial
Synonyms: Car5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12352
HGNC: HGNC:1377
Homologene: 68200
Ccnj
Name: cyclin J
Synonyms: D430039C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240665
Homologene: 10413
Mogat2
Name: monoacylglycerol O-acyltransferase 2
Synonyms: Mgat2, DGAT2L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233549
Homologene: 57020
Vdr
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor
Synonyms: Nr1i1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22337
Homologene: 37297
Ankrd29
Name: ankyrin repeat domain 29
Synonyms: G630054C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225187
Homologene: 17839
Dagla
Name: diacylglycerol lipase, alpha
Synonyms: Nsddr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 269060
HGNC: HGNC:1165
Homologene: 4468
Lrrc32
Name: leucine rich repeat containing 32
Synonyms: D7H11S833E, D11S833Eh, Garp, EG434215
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434215
HGNC: HGNC:4161
Homologene: 4027
Gm17305
Name: predicted gene, 17305
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Sfxn2
Name: sideroflexin 2
Synonyms: F630107H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 94279
VEGA: 19
Homologene: 14227
Epor
Name: erythropoietin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13857
VEGA: 9
HGNC: HGNC:3416
Homologene: 95
Myl2
Name: myosin, light polypeptide 2, regulatory, cardiac, slow
Synonyms: MLC-2v, MLC-2, Mlc2v, Mylpc, Gm32672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17906
HGNC: HGNC:7583
Homologene: 55462
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,841,707 bp
  • T to A, chromosome 1 at 43,971,623 bp
  • T to A, chromosome 1 at 193,330,784 bp
  • C to T, chromosome 2 at 76,771,505 bp
  • A to T, chromosome 2 at 156,052,200 bp
  • A to G, chromosome 2 at 163,615,583 bp
  • T to A, chromosome 3 at 34,049,144 bp
  • G to T, chromosome 4 at 140,515,287 bp
  • G to C, chromosome 4 at 148,166,011 bp
  • A to AG, chromosome 5 at 20,602,461 bp
  • C to T, chromosome 5 at 74,620,123 bp
  • G to A, chromosome 5 at 104,310,394 bp
  • T to C, chromosome 5 at 122,104,685 bp
  • A to G, chromosome 5 at 124,388,572 bp
  • A to G, chromosome 6 at 91,465,218 bp
  • G to T, chromosome 6 at 110,646,348 bp
  • G to A, chromosome 7 at 4,936,907 bp
  • T to G, chromosome 7 at 26,086,031 bp
  • T to A, chromosome 7 at 44,858,678 bp
  • A to G, chromosome 7 at 98,499,777 bp
  • A to T, chromosome 7 at 99,222,366 bp
  • T to A, chromosome 7 at 143,894,063 bp
  • A to G, chromosome 8 at 24,810,090 bp
  • A to G, chromosome 8 at 70,772,385 bp
  • T to C, chromosome 8 at 79,353,455 bp
  • A to C, chromosome 8 at 121,939,843 bp
  • A to T, chromosome 9 at 21,959,640 bp
  • T to C, chromosome 10 at 17,806,752 bp
  • C to T, chromosome 10 at 52,172,840 bp
  • T to A, chromosome 10 at 111,269,436 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • T to C, chromosome 11 at 69,364,098 bp
  • T to A, chromosome 11 at 74,270,223 bp
  • T to C, chromosome 11 at 75,665,679 bp
  • C to T, chromosome 11 at 86,299,162 bp
  • C to T, chromosome 11 at 98,892,654 bp
  • T to A, chromosome 12 at 38,783,810 bp
  • A to G, chromosome 12 at 113,188,408 bp
  • T to G, chromosome 13 at 55,105,350 bp
  • C to T, chromosome 13 at 99,412,372 bp
  • A to G, chromosome 15 at 27,773,875 bp
  • T to A, chromosome 15 at 95,943,427 bp
  • T to A, chromosome 15 at 97,859,127 bp
  • C to T, chromosome 15 at 100,551,320 bp
  • T to G, chromosome 16 at 18,079,901 bp
  • A to G, chromosome 17 at 12,404,100 bp
  • C to A, chromosome 17 at 12,698,963 bp
  • G to C, chromosome 17 at 24,289,507 bp
  • C to T, chromosome 17 at 46,981,345 bp
  • T to C, chromosome 17 at 56,044,114 bp
  • G to A, chromosome 18 at 12,254,700 bp
  • A to T, chromosome 18 at 58,069,242 bp
  • T to C, chromosome 19 at 10,271,084 bp
  • T to A, chromosome 19 at 40,844,714 bp
  • C to G, chromosome 19 at 46,592,286 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2879 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040467-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.