Strain Name:
C57BL/6J-MtgxR2880Btlr/Mmmh
Stock Number:
040468-MU
Citation ID:
RRID:MMRRC_040468-MU
Other Names:
R2880 (G1), C57BL/6J-MtgxR2880Btlr
Major Collection:

Gene Information

Pak1
Name: p21 (RAC1) activated kinase 1
Synonyms: PAK-1, Paka
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18479
HGNC: HGNC:8590
Homologene: 1936
Eno1
Name: enolase 1, alpha non-neuron
Synonyms: Eno-1, c-Myc promoter binding protein, MBP-1, alpha-enolase, 2-phospho-D-glycerate hydrolase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: NBCn1, NBC3, E430014N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Ewsr1
Name: Ewing sarcoma breakpoint region 1
Synonyms: Ews
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14030
HGNC: HGNC:3508
Homologene: 134632
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Arih1
Name: ariadne RBR E3 ubiquitin protein ligase 1
Synonyms: UIP77
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23806
HGNC: HGNC:689
Homologene: 111871
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231128
Homologene: 2746
Map3k14
Name: mitogen-activated protein kinase kinase kinase 14
Synonyms: Nik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53859
HGNC: HGNC:6853
Homologene: 2940
H13
Name: histocompatibility 13
Synonyms: Hm13, 4930443L17Rik, 5031424B04Rik, Spp, 1200006O09Rik, H-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14950
Homologene: 7749
Blnk
Name: B cell linker
Synonyms: BLNK, BCA, Ly57, Ly-57, Bca, SLP-65, BASH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17060
Homologene: 32038
Myof
Name: myoferlin
Synonyms: Fer1l3, 2310051D19Rik, E030042N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Maml2
Name: mastermind like transcriptional coactivator 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270118
Homologene: 134147
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Prp9-1, Chd7, Mi-2 alpha, 2600010P09Rik, Prp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhsp, 4832426G23Rik, Myhs-p, MyHC-pn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Brinp3
Name: bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms: Fam5c, B830045N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215378
Homologene: 17786
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20957
Homologene: 2389
Rnf112
Name: ring finger protein 112
Synonyms: neurolastin, Zfp179, bfp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22671
Homologene: 5176
Slc25a30
Name: solute carrier family 25, member 30
Synonyms: 4933433D23Rik, KMCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67554
VEGA: 14
Homologene: 57046
Arhgef38
Name: Rho guanine nucleotide exchange factor (GEF) 38
Synonyms: 9130221D24Rik, D630013G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77669
Homologene: 137396
Slfn10-ps
Name: schlafen 10, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237887
AC165146.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381157
Homologene: 73393
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Lrit1
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Synonyms: Lrrc21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239037
Homologene: 9215
Pex5l
Name: peroxisomal biogenesis factor 5-like
Synonyms: 1700016J08Rik, Pex2, TRIP8b, PXR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 58869
Homologene: 9562
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100009609
Cd300c
Name: CD300C molecule
Synonyms: Clm6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 387565
Homologene: 74580
Mtnr1b
Name: melatonin receptor 1B
Synonyms: Mel1b, Mt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244701
HGNC: HGNC:7464
Homologene: 4350
Zbtb12
Name: zinc finger and BTB domain containing 12
Synonyms: Bat-9, Bat9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193736
Homologene: 18778
Slc5a11
Name: solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms: 2010013B02Rik, Kst1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233836
Homologene: 14184
AC154271.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Rasa4
Name: RAS p21 protein activator 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54153
Homologene: 5080
Card9
Name: caspase recruitment domain family, member 9
Synonyms: LOC332579
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 332579
Homologene: 14150
Tgfb2
Name: transforming growth factor, beta 2
Synonyms: Tgfb-2, Tgf-beta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21808
Homologene: 2432
Lmf2
Name: lipase maturation factor 2
Synonyms: Tmem153, Tmem112b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105847
VEGA: 15
Homologene: 11251
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 146,902,002 bp
  • T to A, chromosome 1 at 186,704,555 bp
  • T to C, chromosome 2 at 26,357,704 bp
  • A to G, chromosome 2 at 152,695,561 bp
  • T to A, chromosome 3 at 32,993,003 bp
  • A to G, chromosome 3 at 55,647,358 bp
  • T to C, chromosome 3 at 102,818,898 bp
  • G to A, chromosome 3 at 133,146,565 bp
  • A to G, chromosome 4 at 150,242,186 bp
  • A to G, chromosome 4 at 154,252,549 bp
  • T to A, chromosome 5 at 34,443,765 bp
  • T to C, chromosome 5 at 136,091,771 bp
  • A to T, chromosome 7 at 84,963,886 bp
  • T to A, chromosome 7 at 97,904,811 bp
  • GGTGC to G, chromosome 7 at 123,239,372 bp
  • T to A, chromosome 8 at 33,574,907 bp
  • A to T, chromosome 9 at 13,620,597 bp
  • T to G, chromosome 9 at 15,862,806 bp
  • A to T, chromosome 9 at 59,407,866 bp
  • C to T, chromosome 9 at 108,113,067 bp
  • C to A, chromosome 11 at 5,078,523 bp
  • G to A, chromosome 11 at 61,450,467 bp
  • A to G, chromosome 11 at 67,297,264 bp
  • T to C, chromosome 11 at 69,352,120 bp
  • A to T, chromosome 11 at 83,030,095 bp
  • C to A, chromosome 11 at 103,221,032 bp
  • A to T, chromosome 11 at 114,959,790 bp
  • G to A, chromosome 13 at 85,127,238 bp
  • T to A, chromosome 14 at 14,773,277 bp
  • A to G, chromosome 14 at 19,401,978 bp
  • T to A, chromosome 14 at 37,057,437 bp
  • A to G, chromosome 14 at 75,770,211 bp
  • A to G, chromosome 15 at 89,351,653 bp
  • T to A, chromosome 17 at 34,895,479 bp
  • A to T, chromosome 18 at 10,547,288 bp
  • T to C, chromosome 19 at 37,923,025 bp
  • T to C, chromosome 19 at 40,962,455 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2880 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040468-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.