Strain Name:
C57BL/6J-MtgxR2882Btlr/Mmmh
Stock Number:
040470-MU
Citation ID:
RRID:MMRRC_040470-MU
Other Names:
R2882 (G1), C57BL/6J-MtgxR2882Btlr
Major Collection:

Gene Information

Ewsr1
Name: Ewing sarcoma breakpoint region 1
Synonyms: Ews
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14030
HGNC: HGNC:3508
Homologene: 134632
Dock5
Name: dedicator of cytokinesis 5
Synonyms: lr2, 1110060D06Rik, rlc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Atxn3
Name: ataxin 3
Synonyms: Sca3, MJD1, 2210008M02Rik, ataxin-3, Mjd, Atx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110616
HGNC: HGNC:7106
Homologene: 3658
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: DD1, AF529169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209743
Homologene: 17782
Kremen1
Name: kringle containing transmembrane protein 1
Synonyms: Krm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 84035
Homologene: 12935
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Cxxc8, Fbl7, lalina, Jhdm1a, Fbxl11, Gm4560, 5530401A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225876
Homologene: 56564
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Klra1
Name: killer cell lectin-like receptor, subfamily A, member 1
Synonyms: Ly49A, Ly49o129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16627
Homologene: 110821
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: DPD, E330028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Cyp4f40
Name: cytochrome P450, family 4, subfamily f, polypeptide 40
Synonyms: EG631304
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 631304
VEGA: 17
Homologene: 117991
Arhgef38
Name: Rho guanine nucleotide exchange factor (GEF) 38
Synonyms: 9130221D24Rik, D630013G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77669
Homologene: 137396
Mmp12
Name: matrix metallopeptidase 12
Synonyms: macrophage elastase, MMP12, Mmel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17381
HGNC: HGNC:7158
Homologene: 20547
Dcaf17
Name: DDB1 and CUL4 associated factor 17
Synonyms: 2810055O12Rik, A030004A10Rik, 4833418A01Rik, A930009G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75763
Homologene: 65979
Dpp10
Name: dipeptidylpeptidase 10
Synonyms: DPRP3, 6430601K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269109
Homologene: 41400
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11981
Homologene: 69194
Gsdmc
Name: gasdermin C
Synonyms: Mlze, Gsdmc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83492
HGNC: HGNC:7151
Homologene: 69487
Ppm1h
Name: protein phosphatase 1H (PP2C domain containing)
Synonyms: ARHCL1, A430075L18Rik, C030002B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319468
Homologene: 18537
Oasl2
Name: 2'-5' oligoadenylate synthetase-like 2
Synonyms: M1204, Mmu-OASL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23962
Homologene: 128369
Tgm6
Name: transglutaminase 6
Synonyms: TGM3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241636
Homologene: 27970
Olfr348
Name: olfactory receptor 348
Synonyms: GA_x6K02T2NLDC-33481050-33481991, MOR136-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258946
HGNC: HGNC:8209
Homologene: 105219
Slc5a11
Name: solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms: 2010013B02Rik, Kst1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233836
Homologene: 14184
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53791
Homologene: 20698
Mpp2
Name: membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Synonyms: Dlg2, Dlgh2, Pals4, D11Bwg0652e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 50997
HGNC: HGNC:7220
Homologene: 3920
Cep112
Name: centrosomal protein 112
Synonyms: 1700001M19Rik, 1700029K01Rik, 8430407H02Rik, Macoco, Ccdc46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76380
Homologene: 44915
1700014D04Rik
Name: RIKEN cDNA 1700014D04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 102638268
Homologene: 140986
Slc14a1
Name: solute carrier family 14 (urea transporter), member 1
Synonyms: 2610507K20Rik, UT-B, 3021401A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108052
Homologene: 9285
Csl
Name: citrate synthase like
Synonyms: 1700007H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71832
VEGA: 10
Homologene: 7131
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 123,445,203 bp
  • C to T, chromosome 1 at 182,973,893 bp
  • A to T, chromosome 2 at 36,787,190 bp
  • A to G, chromosome 2 at 71,082,027 bp
  • T to C, chromosome 2 at 130,137,439 bp
  • T to C, chromosome 2 at 168,706,214 bp
  • A to G, chromosome 3 at 119,065,030 bp
  • G to A, chromosome 3 at 133,146,565 bp
  • C to T, chromosome 5 at 114,911,023 bp
  • A to T, chromosome 6 at 130,377,863 bp
  • GGTGC to G, chromosome 7 at 123,239,372 bp
  • T to A, chromosome 8 at 33,574,907 bp
  • C to T, chromosome 8 at 110,566,923 bp
  • A to G, chromosome 9 at 7,358,236 bp
  • C to T, chromosome 9 at 89,602,802 bp
  • T to C, chromosome 10 at 83,579,501 bp
  • A to G, chromosome 10 at 99,758,925 bp
  • T to A, chromosome 10 at 122,941,334 bp
  • C to A, chromosome 11 at 5,078,523 bp
  • CGGG to CGGGGGG, chromosome 11 at 5,201,791 bp
  • C to A, chromosome 11 at 55,311,305 bp
  • T to C, chromosome 11 at 102,064,633 bp
  • T to C, chromosome 11 at 108,519,212 bp
  • A to T, chromosome 12 at 85,267,566 bp
  • C to A, chromosome 12 at 101,937,411 bp
  • C to A, chromosome 13 at 59,742,943 bp
  • T to C, chromosome 14 at 67,839,620 bp
  • T to C, chromosome 15 at 63,779,795 bp
  • A to G, chromosome 17 at 32,668,073 bp
  • A to T, chromosome 18 at 37,145,812 bp
  • C to A, chromosome 18 at 78,111,556 bp
  • A to G, chromosome 19 at 4,331,184 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2882 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040470-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.