Strain Name:
C57BL/6J-MtgxR2886Btlr/Mmmh
Stock Number:
040474-MU
Citation ID:
RRID:MMRRC_040474-MU
Other Names:
R2886 (G1), C57BL/6J-MtgxR2886Btlr
Major Collection:

Gene Information

Casq2
Name: calsequestrin 2
Synonyms: ESTM52, Csq2, cCSQ, cardiac calsequestrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12373
HGNC: HGNC:1513
Homologene: 20330
Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22288
VEGA: 10
Homologene: 21398
H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-M alpha, H2-Ma, H-2Ma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Il17rd
Name: interleukin 17 receptor D
Synonyms: Sef, Sef-S, 2810004A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 171463
VEGA: 14
Homologene: 9717
Dnajc17
Name: DnaJ heat shock protein family (Hsp40) member C17
Synonyms: D9Bwg1371e, 1700025B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69408
Homologene: 49527
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70797
Homologene: 19076
Smc6
Name: structural maintenance of chromosomes 6
Synonyms: 2810489L22Rik, Smc6l1, 3830418C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 67241
VEGA: 12
Homologene: 41575
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: skNAC, LOC380777
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Cables1
Name: CDK5 and Abl enzyme substrate 1
Synonyms: interactor-1 with cdk3, ik3-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 63955
VEGA: 18
Homologene: 11097
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 2410140K03Rik, D5Ertd591e, 3110031A07Rik, A630018G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76800
Homologene: 35425
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20190
Homologene: 68069
Ell2
Name: elongation factor RNA polymerase II 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 192657
VEGA: 13
Homologene: 8094
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, B330005D23Rik, FOG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22762
VEGA: 15
Homologene: 8008
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: alpha-E1, CD103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Rusc2
Name: RUN and SH3 domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100213
Homologene: 18967
Ipcef1
Name: interaction protein for cytohesin exchange factors 1
Synonyms: A130090K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 320495
Homologene: 32271
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 229003
Homologene: 14118
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Serpinh1
Name: serine (or cysteine) peptidase inhibitor, clade H, member 1
Synonyms: Hsp47, colligin, J6, gp46, Cbp2, Serpinh2, Cbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12406
HGNC: HGNC:1546
Homologene: 20331
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 624845
Homologene: 83483
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: 6720489L24Rik, Adp, Mdga2, 9330209L04Rik, Tg(Prnp-PFN1*G118V)838Kiaei, Mamdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 320772
Homologene: 45659
Pkn1
Name: protein kinase N1
Synonyms: Pkn, F730027O18Rik, PAK1, Stk3, Prkcl1, PRK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Kif21b
Name: kinesin family member 21B
Synonyms: 2610511N21Rik, N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16565
Homologene: 56868
Slc5a4b
Name: solute carrier family 5 (neutral amino acid transporters, system A), member 4b
Synonyms: SGLT3b, 2010104G07Rik, SAAT1, pSGLT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64454
Homologene: 56968
Serpini2
Name: serine (or cysteine) peptidase inhibitor, clade I, member 2
Synonyms: 1810006A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67931
HGNC: HGNC:8945
Homologene: 21248
Lilrb4a
Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4A
Synonyms: HM18, Gp49b, ILT3, CD85K, Lilrb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14728
VEGA: 10
HGNC: HGNC:6608
Homologene: 86756
Sit1
Name: suppression inducing transmembrane adaptor 1
Synonyms: Sit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54390
Homologene: 8694
Naif1
Name: nuclear apoptosis inducing factor 1
Synonyms: 2310007O20Rik, 4933440H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71254
Homologene: 45669
Vmn2r-ps69
Name: vomeronasal 2, receptor, pseudogene 69
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 670926
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Bicdl2
Name: BICD family like cargo adaptor 2
Synonyms: Ccdc64b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 212733
VEGA: 17
Homologene: 17815
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240427
Homologene: 9192
Selenon
Name: selenoprotein N
Synonyms: 1110019I12Rik, Sepn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74777
Homologene: 10723
Slc27a5
Name: solute carrier family 27 (fatty acid transporter), member 5
Synonyms: FACVL3, FATP5, VLCSH2, VLCS-H2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26459
Homologene: 7596
Ccr1l1
Name: chemokine (C-C motif) receptor 1-like 1
Synonyms: Cmkbr1l1, MIP-1 alphaRL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12770
VEGA: 9
Homologene: 56388
Nrk
Name: Nik related kinase
Synonyms: Nesk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 27206
Homologene: 8442
Gm9966
Name: predicted gene 9966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 21,469,547 bp
  • G to A, chromosome 1 at 136,147,874 bp
  • T to G, chromosome 2 at 29,148,625 bp
  • C to T, chromosome 2 at 32,454,875 bp
  • A to G, chromosome 2 at 119,179,452 bp
  • A to G, chromosome 2 at 181,240,742 bp
  • T to C, chromosome 3 at 75,259,614 bp
  • A to T, chromosome 3 at 102,144,218 bp
  • A to G, chromosome 4 at 43,415,456 bp
  • C to T, chromosome 4 at 43,483,314 bp
  • T to C, chromosome 4 at 134,543,069 bp
  • A to T, chromosome 5 at 3,727,666 bp
  • T to C, chromosome 5 at 143,721,629 bp
  • T to A, chromosome 7 at 12,989,560 bp
  • G to T, chromosome 7 at 29,074,798 bp
  • T to C, chromosome 7 at 85,307,624 bp
  • T to C, chromosome 7 at 95,958,546 bp
  • T to C, chromosome 7 at 99,349,021 bp
  • G to A, chromosome 8 at 83,681,238 bp
  • T to C, chromosome 9 at 123,977,516 bp
  • C to T, chromosome 10 at 6,900,641 bp
  • A to T, chromosome 10 at 12,739,361 bp
  • A to T, chromosome 10 at 51,491,613 bp
  • C to T, chromosome 10 at 76,075,073 bp
  • A to G, chromosome 10 at 79,396,248 bp
  • T to C, chromosome 10 at 128,041,678 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • A to T, chromosome 11 at 73,140,687 bp
  • A to G, chromosome 11 at 110,144,886 bp
  • T to C, chromosome 12 at 11,276,293 bp
  • A to G, chromosome 12 at 66,506,270 bp
  • T to C, chromosome 13 at 75,763,785 bp
  • T to A, chromosome 14 at 27,099,553 bp
  • A to G, chromosome 15 at 41,102,323 bp
  • G to A, chromosome 17 at 23,666,758 bp
  • A to G, chromosome 17 at 34,137,147 bp
  • A to G, chromosome 18 at 11,939,732 bp
  • A to G, chromosome 18 at 78,859,940 bp
  • T to C, chromosome X at 138,975,448 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2886 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040474-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.