Strain Name:
C57BL/6J-MtgxR2900Btlr/Mmmh
Stock Number:
040488-MU
Citation ID:
RRID:MMRRC_040488-MU
Other Names:
R2900 (G1), C57BL/6J-MtgxR2900Btlr
Major Collection:

Strain Information

Pan2
Name: PAN2 poly(A) specific ribonuclease subunit
Synonyms: 1200014O24Rik, Usp52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103135
VEGA: 10
Homologene: 5918
Gpsm1
Name: G-protein signalling modulator 1 (AGS3-like, C. elegans)
Synonyms: 1810037C22Rik, Ags3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67839
Homologene: 16987
Strip2
Name: striatin interacting protein 2
Synonyms: Myoscape, D330017J20Rik, Fam40b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320609
Homologene: 66198
Ms4a6d
Name: membrane-spanning 4-domains, subfamily A, member 6D
Synonyms: Ms4a11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68774
Homologene: 130755
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Pdlim1
Name: PDZ and LIM domain 1 (elfin)
Synonyms: mClim1, CLP36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54132
HGNC: HGNC:2067
Homologene: 9643
Asph
Name: aspartate-beta-hydroxylase
Synonyms: cI-37, 2310005F16Rik, aspartyl beta-hydroxylase, calsequestrin-binding protein, Junctin, jumbug, BAH, 3110001L23Rik, junctate
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 65973
HGNC: HGNC:757
Homologene: 20910
Med18
Name: mediator complex subunit 18
Synonyms: 2810046C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67219
Homologene: 9756
Zfp566
Name: zinc finger protein 566
Synonyms: 2700043M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72556
Homologene: 88470
Slc15a4
Name: solute carrier family 15, member 4
Synonyms: C130069N12Rik, PTR4, PHT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100561
Homologene: 26432
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20850
Homologene: 20680
Syn2
Name: synapsin II
Synonyms: 2900074L19Rik, Synapsin IIb, Synapsin IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20965
Homologene: 49348
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: 1110033O10Rik, 8430411H09Rik, B230107H12Rik, Pp6r2, Saps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo, mSlo1, Slo1, MaxiK, BK channel alpha subunit, 5730414M22Rik, BKCa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Vmn2r83
Name: vomeronasal 2, receptor 83
Synonyms: EG625029
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625029
Homologene: 83669
Thbd
Name: thrombomodulin
Synonyms: CD141, TM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21824
Homologene: 308
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Cyp26b1
Name: cytochrome P450, family 26, subfamily b, polypeptide 1
Synonyms: P450RAI-2, retinoic acid B1, CP26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232174
Homologene: 23179
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 0610043A03Rik, 2210420P05Rik, 2600014C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70297
Homologene: 45639
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Hoxc9
Name: homeobox C9
Synonyms: Hox-3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15427
HGNC: HGNC:5130
Homologene: 130558
Coro6
Name: coronin 6
Synonyms: clipin E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216961
Homologene: 104099
Zfp938
Name: zinc finger protein 938
Synonyms: B230315N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237411
Homologene: 135924
Fbxw5
Name: F-box and WD-40 domain protein 5
Synonyms: Fbw5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 30839
Homologene: 8496
Bahd1
Name: bromo adjacent homology domain containing 1
Synonyms: LOC228536
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228536
Homologene: 8976
Fut7
Name: fucosyltransferase 7
Synonyms: Fuc-TVII, FucT-VII, FTVII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14347
HGNC: HGNC:4018
Homologene: 3296
Cmtm1
Name: CKLF-like MARVEL transmembrane domain containing 1
Synonyms: CHLFH1a, CKLFH1, Cklfsf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100504164
Homologene: 134399
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 105,827,061 bp
  • A to G, chromosome 2 at 25,423,911 bp
  • G to A, chromosome 2 at 25,502,561 bp
  • G to T, chromosome 2 at 26,345,162 bp
  • C to T, chromosome 2 at 118,916,406 bp
  • C to A, chromosome 2 at 148,406,214 bp
  • T to C, chromosome 4 at 9,601,367 bp
  • G to A, chromosome 4 at 132,459,817 bp
  • A to G, chromosome 5 at 127,604,536 bp
  • T to C, chromosome 6 at 29,448,585 bp
  • A to T, chromosome 6 at 29,939,035 bp
  • C to T, chromosome 6 at 84,576,641 bp
  • C to T, chromosome 6 at 115,237,334 bp
  • T to C, chromosome 7 at 30,078,243 bp
  • A to G, chromosome 8 at 104,309,544 bp
  • T to C, chromosome 10 at 58,298,652 bp
  • C to A, chromosome 10 at 79,478,079 bp
  • T to C, chromosome 10 at 82,225,506 bp
  • T to A, chromosome 10 at 128,308,342 bp
  • A to G, chromosome 11 at 77,467,813 bp
  • G to A, chromosome 11 at 100,874,131 bp
  • T to C, chromosome 12 at 4,630,713 bp
  • T to C, chromosome 14 at 23,803,160 bp
  • C to A, chromosome 15 at 89,281,995 bp
  • A to T, chromosome 15 at 102,981,753 bp
  • C to T, chromosome 19 at 11,590,144 bp
  • C to T, chromosome 19 at 40,223,075 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2900 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040488-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.