Strain Name:
C57BL/6J-MtgxR2904Btlr/Mmmh
Stock Number:
040491-MU
Citation ID:
RRID:MMRRC_040491-MU
Other Names:
R2904 (G1), C57BL/6J-MtgxR2904Btlr
Major Collection:

Gene Information

Card11
Name: caspase recruitment domain family, member 11
Synonyms: CARMA1, 0610008L17Rik, BIMP3, 2410011D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108723
Homologene: 13024
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: Jmjd2b, 4732474L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193796
Homologene: 27773
Smarcc1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Synonyms: BAF155, SRG3, msp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20588
Homologene: 68296
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Kif11
Name: kinesin family member 11
Synonyms: Kifl1, Knsl1, Eg5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Ap2a2
Name: adaptor-related protein complex 2, alpha 2 subunit
Synonyms: Adtab, 2410074K14Rik, alpha-C adaptin, L25, alpha-adaptin C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11772
HGNC: HGNC:562
Homologene: 5335
Tut4
Name: terminal uridylyl transferase 4
Synonyms: 9230115F04Rik, Zcchc11, Tent3a, 6030404K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230594
Homologene: 35279
Zfp160
Name: zinc finger protein 160
Synonyms: 6720480D16Rik, 6720480D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224585
VEGA: 17
Homologene: 137372
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 6430549P11Rik, 2A-HUB, 2310047C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224170
Homologene: 8771
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: 6720469N11Rik, Neph1, Kirrel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216850
Homologene: 18945
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, LOC224126, Hapip, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: Ugcgl2, 1810064L21Rik, 3110027P15Rik, 3110001A05Rik, A230065J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66435
Homologene: 56875
Txnip
Name: thioredoxin interacting protein
Synonyms: VDUP1, THIF, mVDUP1, Hyplip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp4b, Nalp-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210045
Homologene: 65242
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Gmpr2
Name: guanosine monophosphate reductase 2
Synonyms: 5730544D12Rik, 1810008P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105446
VEGA: 14
HGNC: HGNC:4377
Homologene: 22983
Olfr113
Name: olfactory receptor 113
Synonyms: MOR218-9, GA_x6K02T2PSCP-2034880-2033942
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258286
Kdr
Name: kinase insert domain protein receptor
Synonyms: Flk-1, VEGF receptor-2, VEGFR2, VEGFR-2, Flk1, orv, vascular endothelial growth factor receptor- 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16542
HGNC: HGNC:6307
Homologene: 55639
Irf9
Name: interferon regulatory factor 9
Synonyms: p48, Irf-9, Isgf3g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16391
HGNC: HGNC:6131
Homologene: 4436
Tas2r118
Name: taste receptor, type 2, member 118
Synonyms: mGR18, Tas2r18, T2R18, mt2r40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387347
Homologene: 9660
Dzip1l
Name: DAZ interacting protein 1-like
Synonyms: 2610524A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72507
Homologene: 12466
Ttc26
Name: tetratricopeptide repeat domain 26
Synonyms: 9430097H08Rik, hpy, hydrocephalic-polydactyl, hop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 264134
Homologene: 11786
Mkrn3
Name: makorin, ring finger protein, 3
Synonyms: D7H15S9-1, Zfp127
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22652
HGNC: HGNC:7114
Homologene: 4143
Crisp1
Name: cysteine-rich secretory protein 1
Synonyms: CRISP-1, Aeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11571
Homologene: 135665
Abraxas1
Name: BRCA1 A complex subunit
Synonyms: Ccdc98, 5630400M01Rik, Fam175a, 3830405G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70681
Homologene: 16376
Olfr483
Name: olfactory receptor 483
Synonyms: MOR204-12, GA_x6K02T2PBJ9-10432095-10433042
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258730
Homologene: 133602
Gm9791
Name: predicted pseudogene 9791
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100040232
Trim21
Name: tripartite motif-containing 21
Synonyms: Ro52, Ssa1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20821
Homologene: 2365
Gm4793
Name: predicted gene 4793
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215714
Acot4
Name: acyl-CoA thioesterase 4
Synonyms: Pte2b, PTE-Ib, B430212I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 171282
Homologene: 44237
Ciao2a
Name: cytosolic iron-sulfur assembly component 2A
Synonyms: Fam96a, 5730536A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68250
Homologene: 12252
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 135,585,238 bp
  • C to T, chromosome 2 at 91,175,672 bp
  • T to C, chromosome 3 at 34,005,187 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • G to A, chromosome 4 at 108,548,040 bp
  • T to C, chromosome 5 at 75,966,409 bp
  • T to C, chromosome 5 at 100,809,807 bp
  • T to C, chromosome 5 at 108,624,214 bp
  • T to C, chromosome 5 at 121,292,724 bp
  • T to A, chromosome 5 at 140,889,133 bp
  • A to G, chromosome 6 at 23,969,802 bp
  • T to C, chromosome 6 at 38,401,102 bp
  • T to A, chromosome 7 at 10,714,367 bp
  • C to A, chromosome 7 at 62,418,459 bp
  • A to G, chromosome 7 at 102,559,971 bp
  • T to C, chromosome 7 at 108,103,599 bp
  • A to G, chromosome 7 at 141,619,478 bp
  • T to C, chromosome 8 at 15,098,348 bp
  • A to G, chromosome 9 at 66,126,978 bp
  • G to T, chromosome 9 at 79,652,025 bp
  • A to T, chromosome 9 at 95,491,489 bp
  • A to G, chromosome 9 at 99,663,669 bp
  • A to G, chromosome 9 at 110,173,975 bp
  • G to A, chromosome 11 at 69,405,785 bp
  • C to G, chromosome 12 at 84,043,603 bp
  • T to C, chromosome 13 at 3,582,185 bp
  • A to G, chromosome 14 at 55,604,249 bp
  • T to C, chromosome 14 at 55,672,758 bp
  • T to A, chromosome 14 at 119,059,109 bp
  • C to T, chromosome 16 at 33,989,810 bp
  • A to G, chromosome 16 at 48,952,171 bp
  • G to A, chromosome 17 at 21,025,649 bp
  • A to T, chromosome 17 at 37,574,814 bp
  • C to T, chromosome 17 at 40,313,004 bp
  • G to A, chromosome 17 at 56,355,884 bp
  • T to C, chromosome 19 at 37,403,655 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2904 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040491-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.