Strain Name:
C57BL/6J-MtgxR2907Btlr/Mmmh
Stock Number:
040494-MU
Citation ID:
RRID:MMRRC_040494-MU
Other Names:
R2907 (G1), C57BL/6J-MtgxR2907Btlr
Major Collection:

Gene Information

Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 64291
Homologene: 84746
Zfp113
Name: zinc finger protein 113
Synonyms: 4732456B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56314
Homologene: 50027
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Uba3
Name: ubiquitin-like modifier activating enzyme 3
Synonyms: ubiquitin activating enzyme 3, A830034N06Rik, Ube1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22200
Homologene: 2951
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76719
Homologene: 9140
Dnm1l
Name: dynamin 1-like
Synonyms: 6330417M19Rik, Drp1, python, Dnmlp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 84505
Homologene: 32157
Kcnk1
Name: potassium channel, subfamily K, member 1
Synonyms: TWIK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16525
HGNC: HGNC:6272
Homologene: 1691
Rbm26
Name: RNA binding motif protein 26
Synonyms: Pro1777, C230097K14Rik, 1700009P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74213
Homologene: 41468
Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14055
HGNC: HGNC:3526
Homologene: 20458
Bcl6
Name: B cell leukemia/lymphoma 6
Synonyms: Bcl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12053
HGNC: HGNC:1001
Homologene: 7640
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Mcpt1
Name: mast cell protease 1
Synonyms: Mcp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17224
VEGA: 14
Homologene: 137209
Igfbp4
Name: insulin-like growth factor binding protein 4
Synonyms: Band 3A, IGFBP-4, Deb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16010
HGNC: HGNC:5473
Homologene: 1192
Zfp738
Name: zinc finger protein 738
Synonyms: 6720487G11Rik, 3830402I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408068
Homologene: 133713
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353188
Homologene: 17021
Aspn
Name: asporin
Synonyms: 4631401G09Rik, SLRR1C, PLAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66695
VEGA: 13
Homologene: 32357
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: beta-prime adaptin, Adtb1, b2b1660Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Psmd4
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Synonyms: Mcb1, multiubiquitin-chain-binding protein, Af1, angiocidin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19185
HGNC: HGNC:9561
Homologene: 55691
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: LOC381127, D930044O18Rik, D430002O22Rik, C230079D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211961
Homologene: 19371
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, A230065J02Rik, Ugcgl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66435
Homologene: 56875
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 674895
Homologene: 130947
Klra3
Name: killer cell lectin-like receptor, subfamily A, member 3
Synonyms: 5E6, Ly49C, Nk-2, Ly49c, NK-2.1, Nk2.1, Nk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16634
Homologene: 110821
Pax9
Name: paired box 9
Synonyms: Pax-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18511
HGNC: HGNC:8623
Homologene: 31360
Astn2
Name: astrotactin 2
Synonyms: 1d8, Astnl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56079
Homologene: 77850
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Asns
Name: asparagine synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27053
HGNC: HGNC:753
Homologene: 69113
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Dpy19l1
Name: dpy-19-like 1 (C. elegans)
Synonyms: 1100001I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244745
Homologene: 14762
Olfr1490
Name: olfactory receptor 1490
Synonyms: GA_x6K02T2RE5P-3987000-3987950, MOR266-6P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258098
Homologene: 79418
Kin
Name: Kin17 DNA and RNA binding protein
Synonyms: Kin17, antigenic determinant of rec-A protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16588
HGNC: HGNC:6327
Homologene: 8196
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384752
Actl6b
Name: actin-like 6B
Synonyms: Baf53b, ArpNa, Actl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83766
HGNC: HGNC:160
Homologene: 81844
Sdr42e1
Name: short chain dehydrogenase/reductase family 42E, member 1
Synonyms: 4632417N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74032
Homologene: 23654
Olfr1437
Name: olfactory receptor 1437
Synonyms: GA_x6K02T2RE5P-2658227-2657289, MOR214-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258117
Homologene: 83129
Otud4
Name: OTU domain containing 4
Synonyms: 4930431L18Rik, D8Ertd69e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73945
Homologene: 35370
H2-T3
Name: histocompatibility 2, T region locus 3
Synonyms: H-2T3, TL, H2-Tw3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15043
Homologene: 74884
Ap5b1
Name: adaptor-related protein complex 5, beta 1 subunit
Synonyms: Gm962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381201
VEGA: 19
Homologene: 16299
Olfr1176
Name: olfactory receptor 1176
Synonyms: GA_x6K02T2Q125-49824309-49825256, MOR174-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258767
Rab36
Name: RAB36, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76877
HGNC: HGNC:9775
Homologene: 3610
Armcx6
Name: armadillo repeat containing, X-linked 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278097
Homologene: 10373
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 2 at 10,091,709 bp
  • T to C, chromosome 2 at 88,340,483 bp
  • G to T, chromosome 3 at 95,033,962 bp
  • T to C, chromosome 3 at 95,327,201 bp
  • A to G, chromosome 4 at 65,644,856 bp
  • A to T, chromosome 5 at 73,076,757 bp
  • A to G, chromosome 5 at 137,567,297 bp
  • T to C, chromosome 5 at 138,144,957 bp
  • A to G, chromosome 6 at 7,675,506 bp
  • T to C, chromosome 6 at 97,203,553 bp
  • G to T, chromosome 6 at 130,333,339 bp
  • A to T, chromosome 6 at 136,708,387 bp
  • A to T, chromosome 7 at 10,378,427 bp
  • G to A, chromosome 8 at 22,011,554 bp
  • A to T, chromosome 8 at 24,863,504 bp
  • T to A, chromosome 8 at 79,673,068 bp
  • G to A, chromosome 8 at 117,662,772 bp
  • G to T, chromosome 8 at 125,995,799 bp
  • A to T, chromosome 9 at 24,430,420 bp
  • G to A, chromosome 10 at 75,044,496 bp
  • T to A, chromosome 11 at 5,031,641 bp
  • A to G, chromosome 11 at 99,041,551 bp
  • A to T, chromosome 11 at 101,194,459 bp
  • T to A, chromosome 11 at 104,424,460 bp
  • C to T, chromosome 12 at 56,709,744 bp
  • G to T, chromosome 13 at 49,551,898 bp
  • T to C, chromosome 13 at 67,670,112 bp
  • C to A, chromosome 14 at 14,980,613 bp
  • T to C, chromosome 14 at 56,020,123 bp
  • T to A, chromosome 14 at 105,142,834 bp
  • C to T, chromosome 14 at 119,019,507 bp
  • T to A, chromosome 15 at 48,011,053 bp
  • A to T, chromosome 16 at 16,314,311 bp
  • G to A, chromosome 16 at 23,968,119 bp
  • G to A, chromosome 17 at 36,187,455 bp
  • A to G, chromosome 18 at 12,871,072 bp
  • A to T, chromosome 18 at 22,517,273 bp
  • G to A, chromosome 18 at 37,990,527 bp
  • T to C, chromosome 19 at 5,568,622 bp
  • T to C, chromosome 19 at 12,322,668 bp
  • C to T, chromosome 19 at 13,655,247 bp
  • A to T, chromosome X at 134,749,450 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2907 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040494-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.