Strain Name:
C57BL/6J-MtgxR2908Btlr/Mmmh
Stock Number:
040495-MU
Citation ID:
RRID:MMRRC_040495-MU
Other Names:
R2908 (G1), C57BL/6J-MtgxR2908Btlr
Major Collection:

Gene Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Fryl
Name: FRY like transcription coactivator
Synonyms: 2510002A14Rik, 2310004H21Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72313
Homologene: 103956
Lima1
Name: LIM domain and actin binding 1
Synonyms: EPLIN, 3526402A12Rik, 1110021C24Rik, epithelial protein lost in neoplasm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 65970
Homologene: 9484
Rbm26
Name: RNA binding motif protein 26
Synonyms: C230097K14Rik, 1700009P03Rik, Pro1777
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 74213
Homologene: 41468
Slc25a40
Name: solute carrier family 25, member 40
Synonyms: B230315F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 319653
Homologene: 6040
Cit
Name: citron
Synonyms: C030025P15Rik, citron kinase, Cit-k, citron-N, CRIK-SK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: beta-prime adaptin, Adtb1, b2b1660Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Clp1
Name: CLP1, cleavage and polyadenylation factor I subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 98985
Homologene: 4975
Dhx29
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 29
Synonyms: E130202M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218629
VEGA: 13
Homologene: 10387
Cbwd1
Name: COBW domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226043
VEGA: 19
Homologene: 6843
Adarb1
Name: adenosine deaminase, RNA-specific, B1
Synonyms: RED1, 1700057H01Rik, D10Bwg0447e, ADAR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 110532
HGNC: HGNC:226
Homologene: 8280
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, 3110027P15Rik, 1810064L21Rik, Ugcgl2, A230065J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66435
Homologene: 56875
Nyap2
Name: neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
Synonyms: 9430031J16Rik, Jr6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241134
Homologene: 18239
Plekhg4
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms: 4931414L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 102075
Homologene: 18516
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, Heatr7b1, OTTMUSG00000020804
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100040766
Homologene: 85300
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: myosin heavy chain 2X, IId, IId/x, Myhsf2, Myhs-f, Myhs-f2, MyHC-IId/x, A530084A17Rik, MYHC-IIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Atp1a4
Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 27222
Homologene: 113769
4932441B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Zfp53
Name: zinc finger protein 53
Synonyms: KRAZ1, Zfp-53, zfas8, Zfp118, D030067O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 24132
VEGA: 17
Homologene: 135946
Pbx3
Name: pre B cell leukemia homeobox 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18516
HGNC: HGNC:8634
Homologene: 21243
Tmem40
Name: transmembrane protein 40
Synonyms: 9030407H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 94346
Homologene: 10124
Cdk14
Name: cyclin-dependent kinase 14
Synonyms: Pftk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18647
HGNC: HGNC:8883
Homologene: 7888
Ivd
Name: isovaleryl coenzyme A dehydrogenase
Synonyms: 6720455E18Rik, 1300016K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56357
HGNC: HGNC:6186
Homologene: 1676
Bhlha9
Name: basic helix-loop-helix family, member a9
Synonyms: A830053O21Rik, Fingerin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 320522
Homologene: 82363
Tmem18
Name: transmembrane protein 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 211986
VEGA: 12
Homologene: 17675
Olfr1176
Name: olfactory receptor 1176
Synonyms: GA_x6K02T2Q125-49824309-49825256, MOR174-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258767
Ccl28
Name: chemokine (C-C motif) ligand 28
Synonyms: Scya28, CCK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56838
VEGA: 13
Homologene: 10649
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 81,087,502 bp
  • CTCTCTCTCTCTCTCTCTCTCTC to CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC, chromosome 1 at 88,247,718 bp
  • A to G, chromosome 1 at 172,234,477 bp
  • G to T, chromosome 2 at 34,172,921 bp
  • A to G, chromosome 2 at 84,724,144 bp
  • T to C, chromosome 2 at 88,340,483 bp
  • A to G, chromosome 2 at 118,877,861 bp
  • T to C, chromosome 5 at 5,249,051 bp
  • C to T, chromosome 5 at 8,427,505 bp
  • A to T, chromosome 5 at 73,076,757 bp
  • C to A, chromosome 5 at 115,981,676 bp
  • A to T, chromosome 6 at 115,742,399 bp
  • T to C, chromosome 8 at 105,380,861 bp
  • A to G, chromosome 10 at 77,313,403 bp
  • T to A, chromosome 11 at 5,031,641 bp
  • C to T, chromosome 11 at 67,220,696 bp
  • T to C, chromosome 11 at 76,672,607 bp
  • A to T, chromosome 12 at 30,587,253 bp
  • A to G, chromosome 13 at 13,669,873 bp
  • A to T, chromosome 13 at 65,033,191 bp
  • T to C, chromosome 13 at 112,927,851 bp
  • C to A, chromosome 13 at 119,650,862 bp
  • T to A, chromosome 14 at 105,142,834 bp
  • C to T, chromosome 14 at 119,019,507 bp
  • C to T, chromosome 15 at 99,802,110 bp
  • C to A, chromosome 17 at 21,508,474 bp
  • T to A, chromosome 19 at 24,920,710 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2908 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040495-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.