Strain Name:
C57BL/6J-MtgxR2931Btlr/Mmmh
Stock Number:
040513-MU
Citation ID:
RRID:MMRRC_040513-MU
Other Names:
R2931 (G1), C57BL/6J-MtgxR2931Btlr
Major Collection:

Strain Information

Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, alphaII-spectrin, Spna2, 2610027H02Rik, Spna-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20740
Homologene: 2353
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, dido, D130048F08Rik, Datf1, 6720461J16Rik, C130092D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Map2k4
Name: mitogen-activated protein kinase kinase 4
Synonyms: MKK4, JNKK1, Sek1, Serk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26398
HGNC: HGNC:6844
Homologene: 48159
Dhx15
Name: DEAH-box helicase 15
Synonyms: HRH2, mDEAH9, DEAH (Asp-Glu-Ala-His) box polypeptide 15, Ddx15, DBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13204
HGNC: HGNC:2738
Homologene: 1040
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18733
Homologene: 134028
Sec63
Name: SEC63 homolog, protein translocation regulator
Synonyms: 5730478J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 140740
Homologene: 5220
Kdm5d
Name: lysine demethylase 5D
Synonyms: HY, Jarid1d, Smcy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 20592
Homologene: 55838
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320714
Homologene: 11076
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215772
Homologene: 100289
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 628870
Homologene: 46008
Zscan12
Name: zinc finger and SCAN domain containing 12
Synonyms: Zfp96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 22758
Homologene: 86980
Asb2
Name: ankyrin repeat and SOCS box-containing 2
Synonyms: 1110008E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 65256
Homologene: 69202
Strip1
Name: striatin interacting protein 1
Synonyms: 6530401O14Rik, Fam40a, 6330569M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229707
Homologene: 35064
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74376
Homologene: 53435
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Spata6l
Name: spermatogenesis associated 6 like
Synonyms: 4430402I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381218
Homologene: 128454
Ahcy
Name: S-adenosylhomocysteine hydrolase
Synonyms: SAHH, CuBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269378
HGNC: HGNC:343
Homologene: 554
Gm5699
Name: predicted gene 5699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435616
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 30,998,845 bp
  • A to G, chromosome 2 at 30,018,488 bp
  • G to A, chromosome 2 at 155,065,533 bp
  • T to C, chromosome 2 at 180,661,653 bp
  • T to A, chromosome 3 at 107,625,659 bp
  • G to A, chromosome 5 at 52,166,732 bp
  • A to G, chromosome 5 at 112,693,127 bp
  • A to T, chromosome 7 at 3,717,206 bp
  • A to T, chromosome 8 at 47,503,942 bp
  • C to T, chromosome 10 at 10,442,502 bp
  • A to T, chromosome 10 at 42,827,987 bp
  • A to T, chromosome 10 at 107,820,004 bp
  • A to T, chromosome 11 at 65,756,337 bp
  • T to C, chromosome 12 at 103,334,887 bp
  • A to G, chromosome 13 at 21,364,017 bp
  • G to A, chromosome 19 at 28,948,610 bp
  • G to A, chromosome 19 at 39,849,483 bp
  • T to C, chromosome Y at 942,992 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2931 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040513-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.