Strain Name:
C57BL/6J-MtgxR2971Btlr/Mmmh
Stock Number:
040525-MU
Citation ID:
RRID:MMRRC_040525-MU
Other Names:
R2971 (G1), C57BL/6J-MtgxR2971Btlr
Major Collection:

Gene Information

Myo5a
Name: myosin VA
Synonyms: MyoVA, flail, 9630007J19Rik, Myo5, MVa, Dbv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Ptch1
Name: patched 1
Synonyms: wig, Patched 1, A230106A15Rik, Ptc, Ptc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Ctnnbl1
Name: catenin, beta like 1
Synonyms: 5730471K09Rik, FLJ21108, NYD-SP19, P14L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66642
Homologene: 12003
Aebp2
Name: AE binding protein 2
Synonyms: B230313N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11569
Homologene: 40690
Gdf10
Name: growth differentiation factor 10
Synonyms: Bmp3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14560
VEGA: 14
HGNC: HGNC:4215
Homologene: 3640
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76501
Homologene: 8584
Ap5m1
Name: adaptor-related protein complex 5, mu 1 subunit
Synonyms: 4932432K03Rik, Mudeng
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74385
VEGA: 14
Homologene: 10081
Ilf2
Name: interleukin enhancer binding factor 2
Synonyms: Tex261, TEG-267, Tex267, 6230405A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67781
HGNC: HGNC:6037
Homologene: 26894
Tmem201
Name: transmembrane protein 201
Synonyms: Samp1, D4Ertd429e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230917
Homologene: 35319
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Slc15a4
Name: solute carrier family 15, member 4
Synonyms: PHT1, C130069N12Rik, PTR4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100561
Homologene: 26432
Plxna2
Name: plexin A2
Synonyms: 2810428A13Rik, Plxn2, OCT, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Ptprd
Name: protein tyrosine phosphatase, receptor type, D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434377
Homologene: 103820
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668940
Homologene: 66117
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101095
Homologene: 2647
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4, Naip-rs4A, Birc1f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Gucy2g
Name: guanylate cyclase 2g
Synonyms: GC-G, 2410077I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73707
Homologene: 44544
Olfr741
Name: olfactory receptor 741
Synonyms: MOR106-15, GA_x6K02T2PMLR-6197851-6198786, MOR106-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258233
Cyp2j6
Name: cytochrome P450, family 2, subfamily j, polypeptide 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13110
HGNC: HGNC:2634
Homologene: 68091
Gm20431
Name: predicted gene 20431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Plch2
Name: phospholipase C, eta 2
Synonyms: PLCeta2, A930027K05Rik, Plcl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-N, Ces-N, Es1, Es-4, Es-1, Ee-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Bphl
Name: biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)
Synonyms: 5730533B08Rik, 2010012D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68021
VEGA: 13
HGNC: HGNC:1094
Homologene: 55812
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: 4930417M19Rik, FetA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320571
Homologene: 99882
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230815
Homologene: 69303
Acan
Name: aggrecan
Synonyms: Agc1, b2b183Clo, Cspg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Olfr1040
Name: olfactory receptor 1040
Synonyms: GA_x6K02T2Q125-47615732-47614791, MOR185-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404323
Homologene: 79382
Plscr2
Name: phospholipid scramblase 2
Synonyms: PL scramblase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18828
Homologene: 134152
Skint1
Name: selection and upkeep of intraepithelial T cells 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 639781
Homologene: 87538
Irgm1
Name: immunity-related GTPase family M member 1
Synonyms: Iigp3, Ifi1, LRG-47, Irgm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15944
Homologene: 134089
Zfp697
Name: zinc finger protein 697
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242109
Homologene: 18241
Ifit3b
Name: interferon-induced protein with tetratricopeptide repeats 3B
Synonyms: I830012O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 667370
HGNC: HGNC:5411
Homologene: 1189
Smad9
Name: SMAD family member 9
Synonyms: Madh9, SMAD8A, SMAD8B, MADH6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
Nme6
Name: NME/NM23 nucleoside diphosphate kinase 6
Synonyms: non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase), nm23-M6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54369
Homologene: 4231
Psmb11
Name: proteasome (prosome, macropain) subunit, beta type, 11
Synonyms: beta5t, 5830406J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 73902
VEGA: 14
Homologene: 13729
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 194,797,731 bp
  • T to C, chromosome 2 at 86,146,564 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • A to G, chromosome 2 at 155,632,255 bp
  • C to T, chromosome 2 at 157,871,186 bp
  • T to C, chromosome 2 at 167,610,336 bp
  • T to C, chromosome 3 at 54,797,353 bp
  • T to A, chromosome 3 at 90,486,173 bp
  • T to C, chromosome 3 at 98,428,301 bp
  • T to C, chromosome 4 at 43,361,953 bp
  • T to G, chromosome 4 at 76,107,324 bp
  • T to C, chromosome 4 at 96,531,781 bp
  • C to A, chromosome 4 at 112,021,330 bp
  • G to C, chromosome 4 at 134,703,438 bp
  • A to G, chromosome 4 at 149,722,445 bp
  • T to G, chromosome 4 at 154,990,767 bp
  • A to G, chromosome 5 at 127,604,536 bp
  • A to T, chromosome 6 at 47,897,932 bp
  • T to C, chromosome 6 at 140,633,898 bp
  • A to G, chromosome 7 at 79,099,699 bp
  • T to A, chromosome 8 at 93,104,193 bp
  • C to A, chromosome 9 at 20,348,944 bp
  • T to C, chromosome 9 at 75,116,202 bp
  • G to T, chromosome 9 at 92,290,671 bp
  • A to G, chromosome 9 at 109,842,091 bp
  • A to T, chromosome 11 at 48,866,590 bp
  • A to G, chromosome 12 at 54,923,439 bp
  • A to T, chromosome 13 at 34,046,964 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • C to T, chromosome 13 at 100,300,600 bp
  • G to A, chromosome 14 at 33,924,191 bp
  • A to G, chromosome 14 at 33,954,454 bp
  • T to A, chromosome 14 at 49,083,882 bp
  • T to A, chromosome 14 at 50,485,608 bp
  • T to C, chromosome 14 at 54,625,343 bp
  • C to T, chromosome 19 at 34,612,017 bp
  • A to G, chromosome 19 at 55,210,276 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2971 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040525-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.