Strain Name:
C57BL/6J-MtgxR3112Btlr/Mmmh
Stock Number:
040585-MU
Citation ID:
RRID:MMRRC_040585-MU
Other Names:
R3112 (G1), C57BL/6J-MtgxR3112Btlr
Major Collection:

Gene Information

Olr1
Name: oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms: LOX-1, Scare1, SR-EI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108078
HGNC: HGNC:8133
Homologene: 1910
Jarid2
Name: jumonji, AT rich interactive domain 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Mip
Name: major intrinsic protein of lens fiber
Synonyms: MIP26, Aqp0, Svl, Lop, lens opacity, shrivelled, aquaporin 0, Cts
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17339
HGNC: HGNC:7103
Homologene: 40627
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: B3RP, Ae2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20535
Homologene: 128699
Grhl2
Name: grainyhead like transcription factor 2
Synonyms: BOM, 0610015A08Rik, Tcfcp2l3, grainyheadlike, clft3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 252973
HGNC: HGNC:2799
Homologene: 32616
Traf3ip1
Name: TRAF3 interacting protein 1
Synonyms: 3930402D05Rik, MIP-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74019
Homologene: 22913
Prpf3
Name: pre-mRNA processing factor 3
Synonyms: 3632413F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70767
Homologene: 3447
Nodal
Name: nodal
Synonyms: Tg.413d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18119
HGNC: HGNC:7865
Homologene: 8417
Sppl3
Name: signal peptide peptidase 3
Synonyms: 4833416I09Rik, Usmg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74585
Homologene: 15563
Pdcd10
Name: programmed cell death 10
Synonyms: TF-1 cell apoptosis related protein-15, Tfa15, 2410003B13Rik, CCM3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56426
HGNC: HGNC:8761
Homologene: 10505
Cdc7
Name: cell division cycle 7 (S. cerevisiae)
Synonyms: Cdc7, muCdc7, Cdc7l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12545
HGNC: HGNC:1745
Homologene: 31166
Sympk
Name: symplekin
Synonyms: 4632415H16Rik, 1500016F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68188
Homologene: 37969
Prkcb
Name: protein kinase C, beta
Synonyms: Pkcb, A130082F03Rik, PKC-Beta, Prkcb2, Prkcb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18751
HGNC: HGNC:9395
Homologene: 56424
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 1810037O03Rik, 9530009M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Anpep
Name: alanyl (membrane) aminopeptidase
Synonyms: Cd13, aminopeptidase N, Apn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Grn
Name: granulin
Synonyms: acrogranulin, epithelin, PC cell-derived growth factor, progranulin, Pgrn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14824
HGNC: HGNC:4601
Homologene: 1577
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: mtrp6, Trrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Abca6
Name: ATP-binding cassette, sub-family A (ABC1), member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270198
HGNC: HGNC:8875
Homologene: 48288
Tas2r120
Name: taste receptor, type 2, member 120
Synonyms: mGR20, Tas2r20, T2R20, mt2r47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387348
Homologene: 135705
Tas2r110
Name: taste receptor, type 2, member 110
Synonyms: T2R10, Tas2r10, STC 9-1, mt2r57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387344
Homologene: 130069
Zfp879
Name: zinc finger protein 879
Synonyms: 9630041N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 214779
Homologene: 45452
Itgav
Name: integrin alpha V
Synonyms: vitronectin receptor alpha polypeptide (VNRA), CD51, alphav-integrin, 1110004F14Rik, 2610028E01Rik, D430040G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Wnt11
Name: wingless-type MMTV integration site family, member 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22411
Homologene: 20970
Hmgxb3
Name: HMG box domain containing 3
Synonyms: 2510002C16Rik, A630042L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106894
VEGA: 18
Homologene: 44229
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 2810483I07Rik, UBP-M, 1200004E02Rik, 6330514E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74112
Homologene: 38183
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93838
Homologene: 14143
Gm7030
Name: predicted gene 7030
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 630294
HGNC: HGNC:4963
Homologene: 133121
Itfg2
Name: integrin alpha FG-GAP repeat containing 2
Synonyms: 2700050P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101142
Homologene: 10211
Dvl1
Name: dishevelled segment polarity protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13542
HGNC: HGNC:3084
Homologene: 20926
Acads
Name: acyl-Coenzyme A dehydrogenase, short chain
Synonyms: SCAD, Bcd-1, Bcd1, Hdlq8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11409
HGNC: HGNC:90
Homologene: 20057
Potea
Name: POTE ankyrin domain family member A
Synonyms: 4930430A15Rik, A26c3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67575
Homologene: 69410
Gm4952
Name: predicted gene 4952
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240549
Homologene: 72602
Olfr294
Name: olfactory receptor 294
Synonyms: GA_x6K02T2NHDJ-9504525-9505532, MOR219-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257904
Phactr3
Name: phosphatase and actin regulator 3
Synonyms: scapinin, 1500003N10Rik, 4930415A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74189
Homologene: 14482
Reg3a
Name: regenerating islet-derived 3 alpha
Synonyms: RegIII (alpha)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19694
HGNC: HGNC:8601
Homologene: 136247
H1f4
Name: H1.4 linker histone, cluster member
Synonyms: H1s-4, H1e, H1var2, H1-4, H1f4, Hist1h1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 50709
HGNC: HGNC:4718
Homologene: 137314
Pcmtd2
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Synonyms: 5330414D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 245867
Homologene: 10099
Olfr536
Name: olfactory receptor 536
Synonyms: GA_x6K02T2PBJ9-42653501-42652578, MOR252-1, MOR252-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258513
Homologene: 51731
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 91,521,172 bp
  • T to A, chromosome 1 at 134,872,832 bp
  • G to A, chromosome 1 at 136,075,093 bp
  • T to A, chromosome 2 at 83,792,571 bp
  • T to G, chromosome 2 at 111,228,054 bp
  • T to A, chromosome 2 at 178,279,017 bp
  • A to T, chromosome 2 at 181,855,129 bp
  • A to G, chromosome 3 at 75,517,615 bp
  • A to T, chromosome 3 at 95,849,800 bp
  • T to A, chromosome 4 at 155,853,666 bp
  • T to A, chromosome 5 at 24,435,026 bp
  • T to G, chromosome 5 at 106,974,698 bp
  • A to T, chromosome 5 at 115,074,864 bp
  • T to C, chromosome 5 at 115,117,698 bp
  • A to G, chromosome 6 at 48,457,600 bp
  • T to C, chromosome 6 at 78,381,131 bp
  • T to C, chromosome 6 at 83,058,972 bp
  • T to C, chromosome 6 at 128,411,669 bp
  • T to C, chromosome 6 at 129,499,918 bp
  • A to T, chromosome 6 at 132,657,768 bp
  • T to A, chromosome 6 at 132,868,024 bp
  • T to C, chromosome 7 at 19,034,484 bp
  • T to C, chromosome 7 at 79,841,972 bp
  • T to C, chromosome 7 at 86,615,676 bp
  • T to C, chromosome 7 at 98,846,564 bp
  • T to A, chromosome 7 at 122,516,856 bp
  • A to G, chromosome 7 at 140,503,919 bp
  • T to C, chromosome 9 at 8,610,483 bp
  • C to T, chromosome 9 at 109,025,042 bp
  • G to A, chromosome 10 at 61,424,497 bp
  • T to A, chromosome 10 at 128,226,006 bp
  • T to G, chromosome 11 at 50,833,162 bp
  • A to G, chromosome 11 at 102,433,243 bp
  • T to A, chromosome 11 at 110,178,829 bp
  • T to C, chromosome 13 at 23,621,846 bp
  • T to A, chromosome 13 at 44,906,276 bp
  • T to C, chromosome 15 at 37,336,347 bp
  • T to A, chromosome 16 at 87,471,848 bp
  • T to C, chromosome 17 at 36,129,146 bp
  • T to C, chromosome 18 at 44,449,263 bp
  • T to C, chromosome 18 at 61,147,382 bp
  • T to A, chromosome 19 at 12,626,707 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3112 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040585-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.