Strain Name:
C57BL/6J-MtgxR3176Btlr/Mmmh
Stock Number:
040614-MU
Citation ID:
RRID:MMRRC_040614-MU
Other Names:
R3176 (G1), C57BL/6J-MtgxR3176Btlr
Major Collection:

Gene Information

Atox1
Name: antioxidant 1 copper chaperone
Synonyms: ATX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11927
HGNC: HGNC:798
Homologene: 2984
Dhcr24
Name: 24-dehydrocholesterol reductase
Synonyms: 5830417J06Rik, seladin-1, 3-beta-hydroxysterol delta-24 reductase, 2310076D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74754
HGNC: HGNC:2859
Homologene: 8850
Kif15
Name: kinesin family member 15
Synonyms: N-10 kinesin, HKLP2, 3930402I10Rik, 3110023M17Rik, Knsl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Os9
Name: amplified in osteosarcoma
Synonyms: 4632413K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216440
VEGA: 10
Homologene: 31409
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: 3222402C23Rik, Als2cr6, 9430073A21Rik, Alsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Dcp1a
Name: decapping mRNA 1A
Synonyms: 1110066A22Rik, SMIF, 4930568L04Rik, D14Ertd817e, Mitc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75901
VEGA: 14
Homologene: 10178
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: CRP-[b], CRP-[a], ebnerin, hensin, vomeroglandin, Crpd, MUCLIN, gp300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Ces2a
Name: carboxylesterase 2A
Synonyms: 9130231C15Rik, Ces6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102022
HGNC: HGNC:1864
Homologene: 136396
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245026
Homologene: 18260
Gm11492
Name: predicted gene 11492
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Padi6
Name: peptidyl arginine deiminase, type VI
Synonyms: ePAD, Padi5, Pad6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242726
Homologene: 17695
Dhx58
Name: DEXH (Asp-Glu-X-His) box polypeptide 58
Synonyms: B430001I08Rik, LPG2, D11Lgp2e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 80861
Homologene: 69371
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Ace
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms: CD143
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Sp110
Name: Sp110 nuclear body protein
Synonyms: 52kDa, Ipr1, 5031415C07Rik, 5830484A20Rik, Ifi75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Olfr584
Name: olfactory receptor 584
Synonyms: GA_x6K02T2PBJ9-5796876-5797820, MOR30-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259056
Mrpl19
Name: mitochondrial ribosomal protein L19
Synonyms: MRP-L15, D6Ertd157e, Rpml15, RLX1, 9030416F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56284
Homologene: 8851
Zswim9
Name: zinc finger SWIM-type containing 9
Synonyms: 6330408A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 321008
Homologene: 52386
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56185
HGNC: HGNC:4810
Homologene: 97412
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434172
Homologene: 45597
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433586
Homologene: 41284
Lhfpl5
Name: lipoma HMGIC fusion partner-like 5
Synonyms: 9330179O15Rik, Tmhs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328789
Homologene: 18794
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 194126
Homologene: 82382
Prkx
Name: protein kinase, X-linked
Synonyms: Pkare
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 19108
HGNC: HGNC:9441
Homologene: 55868
Olfr913
Name: olfactory receptor 913
Synonyms: GA_x6K02T2PVTD-32296575-32297513, MOR165-9P, MOR165-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258225
VEGA: 9
Homologene: 79398
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 59,170,008 bp
  • A to C, chromosome 1 at 85,577,329 bp
  • A to G, chromosome 1 at 140,609,639 bp
  • A to T, chromosome 3 at 51,856,930 bp
  • T to C, chromosome 3 at 96,167,891 bp
  • T to C, chromosome 3 at 98,880,328 bp
  • T to C, chromosome 4 at 106,561,239 bp
  • A to G, chromosome 4 at 140,735,389 bp
  • T to C, chromosome 6 at 81,964,066 bp
  • T to C, chromosome 7 at 13,277,270 bp
  • A to G, chromosome 7 at 41,288,380 bp
  • C to A, chromosome 7 at 103,085,750 bp
  • C to A, chromosome 7 at 128,190,981 bp
  • A to G, chromosome 7 at 131,088,071 bp
  • A to G, chromosome 8 at 104,739,378 bp
  • T to A, chromosome 9 at 38,594,643 bp
  • T to C, chromosome 9 at 105,786,230 bp
  • G to A, chromosome 9 at 110,636,887 bp
  • T to C, chromosome 9 at 122,987,840 bp
  • A to G, chromosome 10 at 127,100,076 bp
  • A to G, chromosome 11 at 55,450,553 bp
  • T to C, chromosome 11 at 87,567,244 bp
  • A to G, chromosome 11 at 100,696,979 bp
  • A to G, chromosome 11 at 105,976,702 bp
  • A to G, chromosome 12 at 86,244,315 bp
  • A to G, chromosome 14 at 30,505,542 bp
  • T to C, chromosome 17 at 28,579,946 bp
  • A to T, chromosome X at 77,771,275 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3176 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040614-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.