Strain Name:
C57BL/6J-MtgxR3418Btlr/Mmmh
Stock Number:
040636-MU
Citation ID:
RRID:MMRRC_040636-MU
Other Names:
R3418 (G1), C57BL/6J-MtgxR3418Btlr
Major Collection:

Gene Information

Nos2
Name: nitric oxide synthase 2, inducible
Synonyms: iNOS, NOS-II, Nos2a, Nos-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18126
HGNC: HGNC:7873
Homologene: 55473
Ubp1
Name: upstream binding protein 1
Synonyms: LBP-1a, LBP-1b, NF2d9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22221
VEGA: 9
Homologene: 8435
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66011
Homologene: 36409
Smc2
Name: structural maintenance of chromosomes 2
Synonyms: Smc2l1, CAP-E, Fin16, 5730502P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14211
Homologene: 4705
Armc9
Name: armadillo repeat containing 9
Synonyms: 3830422A13Rik, 4930438O05Rik, 5730415N24Rik, 4831423D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78795
Homologene: 11847
Dido1
Name: death inducer-obliterator 1
Synonyms: D130048F08Rik, dido, Datf1, 6720461J16Rik, DIO-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Fdft1
Name: farnesyl diphosphate farnesyl transferase 1
Synonyms: Ss, SQS, squalene synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14137
VEGA: 14
HGNC: HGNC:3629
Homologene: 3281
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, 9030205D12Rik, A330063D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Sel1l
Name: sel-1 suppressor of lin-12-like (C. elegans)
Synonyms: Sel1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20338
Homologene: 31286
Serpini1
Name: serine (or cysteine) peptidase inhibitor, clade I, member 1
Synonyms: Ns, Spi17, Neuroserpin, PI12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20713
HGNC: HGNC:8943
Homologene: 21045
Fntb
Name: farnesyltransferase, CAAX box, beta
Synonyms: 2010013E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110606
HGNC: HGNC:3785
Homologene: 1535
Ubn1
Name: ubinuclein 1
Synonyms: 2610108L02Rik, 1110029L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 170644
VEGA: 16
Homologene: 9656
Ptcd3
Name: pentatricopeptide repeat domain 3
Synonyms: 2810422B04Rik, 2610034F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69956
Homologene: 41211
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: Gucy1a3, sGC-alpha1, alpha 1 sGC, 1200016O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19876
Homologene: 2206
Htr1f
Name: 5-hydroxytryptamine (serotonin) receptor 1F
Synonyms: Htr1eb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15557
VEGA: 16
HGNC: HGNC:5292
Homologene: 37361
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Esam
Name: endothelial cell-specific adhesion molecule
Synonyms: 2310008D05Rik, W117m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69524
Homologene: 12316
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Cep170b
Name: centrosomal protein 170B
Synonyms: AW555464
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217882
VEGA: 12
Homologene: 46165
Rbm45
Name: RNA binding motif protein 45
Synonyms: Drbp1, Drb1, G430095G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241490
Homologene: 15560
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216766
Homologene: 9155
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Clec9a
Name: C-type lectin domain family 9, member a
Synonyms: DNGR-1, 9830005G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232414
Homologene: 52106
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Myof
Name: myoferlin
Synonyms: Fer1l3, 2310051D19Rik, E030042N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms: Tak1 binding protein 2, 1110030N06Rik, A530078N03Rik, Map3k7ip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68652
Homologene: 9019
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Rnf168
Name: ring finger protein 168
Synonyms: 3110001H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70238
Homologene: 87044
Fat2
Name: FAT atypical cadherin 2
Synonyms: Fath2, EMI2, mKIAA0811, LOC245827
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Khdrbs3
Name: KH domain containing, RNA binding, signal transduction associated 3
Synonyms: SLM-2, T-STAR, Salp, Etle
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13992
VEGA: 15
Homologene: 4780
Cdh5
Name: cadherin 5
Synonyms: VE-Cad, CD144, VECD, VE-cadherin, 7B4/cadherin-5, VEC, VEcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12562
HGNC: HGNC:1764
Homologene: 1359
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Fhl5
Name: four and a half LIM domains 5
Synonyms: ACT, 1700027G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 57756
Homologene: 23230
Cdc16
Name: CDC16 cell division cycle 16
Synonyms: 2700071J12Rik, 2810431D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69957
HGNC: HGNC:1720
Homologene: 2899
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Mbd6
Name: methyl-CpG binding domain protein 6
Synonyms: D10Wsu93e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110962
Homologene: 14171
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320558
Homologene: 8604
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NR2B, Nmdar2b, GluRepsilon2, NMDAR2B, GluN2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
5530400C23Rik
Name: RIKEN cDNA 5530400C23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232426
Homologene: 79760
Unc13a
Name: unc-13 homolog A
Synonyms: 2410078G03Rik, Munc13-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382018
Homologene: 11279
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Pou6f1
Name: POU domain, class 6, transcription factor 1
Synonyms: cns-1, 2310038G18Rik, Emb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19009
HGNC: HGNC:9224
Homologene: 7703
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83561
Homologene: 12850
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: Nadc1, mNaDC-1, sodium/dicarboxylate co-transporter
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20500
Homologene: 2965
Gm4736
Name: predicted gene 4736
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100502592
D130040H23Rik
Name: RIKEN cDNA D130040H23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 211135
Homologene: 138403
Fam20c
Name: family with sequence similarity 20, member C
Synonyms: DMP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80752
Homologene: 56879
P2ry1
Name: purinergic receptor P2Y, G-protein coupled 1
Synonyms: P2Y1, P2Y1 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18441
HGNC: HGNC:8539
Homologene: 1926
Gsto1
Name: glutathione S-transferase omega 1
Synonyms: GSTX, p28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14873
Homologene: 37971
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: TRANCE-R, Rank
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: Ccp5, 9430057O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231093
Homologene: 11053
Kcnj13
Name: potassium inwardly-rectifying channel, subfamily J, member 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040591
HGNC: HGNC:6259
Homologene: 55638
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TbetaR-II, TBR-II, TbetaRII, 1110020H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Acaa1a
Name: acetyl-Coenzyme A acyltransferase 1A
Synonyms: peroxisomal 3-ketoacyl-CoA thiolase, Acaa1, thiolase A, D9Ertd25e, PTL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 113868
HGNC: HGNC:82
Homologene: 37497
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: PI13, HURPIN, headpin, HUR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Ids
Name: iduronate 2-sulfatase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 15931
HGNC: HGNC:5389
Homologene: 169
Dnajb14
Name: DnaJ heat shock protein family (Hsp40) member B14
Synonyms: 5730496F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70604
Homologene: 57015
Jakmip3
Name: janus kinase and microtubule interacting protein 3
Synonyms: 6330417G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74004
Homologene: 90425
Olfr399
Name: olfactory receptor 399
Synonyms: GA_x6K02T2P1NL-4211516-4210581, MOR255-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259006
Homologene: 27325
Rnf222
Name: ring finger protein 222
Synonyms: 9930039A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320040
Homologene: 18544
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 14,874,381 bp
  • T to C, chromosome 1 at 86,194,338 bp
  • T to C, chromosome 1 at 87,386,919 bp
  • T to C, chromosome 1 at 90,804,091 bp
  • A to G, chromosome 1 at 105,809,405 bp
  • T to C, chromosome 1 at 106,998,927 bp
  • A to G, chromosome 2 at 76,379,018 bp
  • T to C, chromosome 2 at 125,320,926 bp
  • A to T, chromosome 2 at 178,401,653 bp
  • G to T, chromosome 2 at 180,660,935 bp
  • T to C, chromosome 3 at 61,003,712 bp
  • A to T, chromosome 3 at 64,116,899 bp
  • A to G, chromosome 3 at 75,640,282 bp
  • A to G, chromosome 3 at 82,106,133 bp
  • A to G, chromosome 3 at 137,892,870 bp
  • A to T, chromosome 4 at 3,746,833 bp
  • T to C, chromosome 4 at 25,211,252 bp
  • T to C, chromosome 4 at 52,476,850 bp
  • T to C, chromosome 5 at 30,904,723 bp
  • A to T, chromosome 5 at 138,757,868 bp
  • A to T, chromosome 6 at 71,883,486 bp
  • A to G, chromosome 6 at 129,421,038 bp
  • A to T, chromosome 6 at 132,115,677 bp
  • A to G, chromosome 6 at 133,294,119 bp
  • T to C, chromosome 6 at 135,843,110 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • C to A, chromosome 7 at 139,017,745 bp
  • C to T, chromosome 8 at 13,769,489 bp
  • T to G, chromosome 8 at 15,085,294 bp
  • T to C, chromosome 8 at 69,302,927 bp
  • C to A, chromosome 8 at 71,645,959 bp
  • T to C, chromosome 8 at 91,036,591 bp
  • C to T, chromosome 8 at 104,129,370 bp
  • C to T, chromosome 9 at 37,537,130 bp
  • T to C, chromosome 9 at 113,951,686 bp
  • T to C, chromosome 9 at 116,129,833 bp
  • A to G, chromosome 9 at 119,349,490 bp
  • G to A, chromosome 10 at 7,907,481 bp
  • C to A, chromosome 10 at 74,584,222 bp
  • C to G, chromosome 10 at 127,286,503 bp
  • A to T, chromosome 11 at 33,289,552 bp
  • A to T, chromosome 11 at 34,689,760 bp
  • G to T, chromosome 11 at 55,278,998 bp
  • A to T, chromosome 11 at 58,156,628 bp
  • G to T, chromosome 11 at 68,893,156 bp
  • G to A, chromosome 11 at 74,053,988 bp
  • A to G, chromosome 11 at 78,400,840 bp
  • T to A, chromosome 11 at 78,959,695 bp
  • C to A, chromosome 12 at 76,887,888 bp
  • A to G, chromosome 12 at 91,810,002 bp
  • A to G, chromosome 12 at 95,780,604 bp
  • C to T, chromosome 12 at 112,738,468 bp
  • T to C, chromosome 14 at 63,156,621 bp
  • T to C, chromosome 15 at 69,049,375 bp
  • C to A, chromosome 15 at 100,580,924 bp
  • A to G, chromosome 16 at 5,074,379 bp
  • A to G, chromosome 16 at 32,299,192 bp
  • G to A, chromosome 16 at 64,925,897 bp
  • C to T, chromosome 16 at 73,035,917 bp
  • A to G, chromosome 19 at 37,922,978 bp
  • T to C, chromosome 19 at 47,857,905 bp
  • T to A, chromosome 19 at 56,831,231 bp
  • A to G, chromosome X at 70,353,284 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3418 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040636-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.