Strain Name:
C57BL/6J-MtgxR3423Btlr/Mmmh
Stock Number:
040641-MU
Citation ID:
RRID:MMRRC_040641-MU
Other Names:
R3423 (G1), C57BL/6J-MtgxR3423Btlr
Major Collection:

Gene Information

Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Dtnb
Name: dystrobrevin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13528
HGNC: HGNC:3058
Homologene: 74875
Dyrk3
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226419
HGNC: HGNC:3094
Homologene: 55762
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: Mll, Cxxc7, HTRX1, Mll1, ALL-1, All1, trithorax Drosophila
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Limk1
Name: LIM-domain containing, protein kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16885
HGNC: HGNC:6613
Homologene: 1738
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, spastic paraplegia 11, 6030465E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214585
Homologene: 41614
Akap8
Name: A kinase (PRKA) anchor protein 8
Synonyms: 1200016A02Rik, AKAP95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56399
VEGA: 17
HGNC: HGNC:378
Homologene: 4278
Phactr4
Name: phosphatase and actin regulator 4
Synonyms: C330013F19Rik, 3110001B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100169
Homologene: 41537
Retnlb
Name: resistin like beta
Synonyms: RELMbeta, 9030012B21Rik, Xcp3, Fizz2, Relmb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57263
VEGA: 16
Homologene: 10735
Sez6l
Name: seizure related 6 homolog like
Synonyms: Acig1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56747
Homologene: 10895
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Ism2
Name: isthmin 2
Synonyms: LOC217738, Thsd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217738
Homologene: 83509
Sp9
Name: trans-acting transcription factor 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381373
Homologene: 66935
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233813
Homologene: 18607
Cdc16
Name: CDC16 cell division cycle 16
Synonyms: 2810431D22Rik, 2700071J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69957
HGNC: HGNC:1720
Homologene: 2899
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20663
Homologene: 38253
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Fam160b2
Name: family with sequence similarity 160, member B2
Synonyms: G430067P06Rik, Rai16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239170
VEGA: 14
Homologene: 23379
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19886
Homologene: 2207
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Thbs2
Name: thrombospondin 2
Synonyms: Thbs-2, Thrombospondin-2, TSP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277753
Homologene: 134044
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: 3110047P20Rik, B830017A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319807
Homologene: 14974
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17837
Homologene: 136663
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226438
Homologene: 130054
Lrrc14
Name: leucine rich repeat containing 14
Synonyms: E130306I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223664
Homologene: 40970
AC091683.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Slc18b1
Name: solute carrier family 18, subfamily B, member 1
Synonyms: 1110021L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76306
Homologene: 33473
Aldh3a1
Name: aldehyde dehydrogenase family 3, subfamily A1
Synonyms: Aldh3, Ahd-4, Aldh, Ahd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11670
HGNC: HGNC:405
Homologene: 20175
Ceacam5
Name: carcinoembryonic antigen-related cell adhesion molecule 5
Synonyms: Psg30, 1600029H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73250
Homologene: 115938
Slc36a3
Name: solute carrier family 36 (proton/amino acid symporter), member 3
Synonyms: TRAMD2, PAT3, tramdorin2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215332
Homologene: 76175
Meltf
Name: melanotransferrin
Synonyms: CD228, melanotransferrin, MTf, Mfi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 30060
VEGA: 16
HGNC: HGNC:7037
Homologene: 4335
Olfr101
Name: olfactory receptor 101
Synonyms: GA_x6K02T2PSCP-1761617-1760691, MOR250-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258831
HGNC: HGNC:8178
Homologene: 133728
Pramel6
Name: preferentially expressed antigen in melanoma like 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 347711
Homologene: 77635
Gm11110
Name: predicted gene 11110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100169874
VEGA: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 131,129,482 bp
  • A to G, chromosome 1 at 135,998,641 bp
  • G to A, chromosome 2 at 73,273,971 bp
  • T to A, chromosome 2 at 87,510,796 bp
  • C to T, chromosome 2 at 122,071,053 bp
  • A to C, chromosome 4 at 115,327,274 bp
  • A to C, chromosome 4 at 132,369,747 bp
  • A to T, chromosome 5 at 63,800,161 bp
  • T to C, chromosome 5 at 112,426,749 bp
  • A to G, chromosome 5 at 134,672,669 bp
  • T to C, chromosome 6 at 122,047,506 bp
  • G to A, chromosome 7 at 17,757,637 bp
  • T to C, chromosome 7 at 102,184,877 bp
  • T to C, chromosome 7 at 120,799,111 bp
  • G to A, chromosome 7 at 141,638,400 bp
  • A to G, chromosome 8 at 13,763,808 bp
  • A to G, chromosome 8 at 81,952,261 bp
  • A to C, chromosome 9 at 44,820,097 bp
  • G to T, chromosome 9 at 73,930,653 bp
  • T to G, chromosome 10 at 23,822,976 bp
  • C to A, chromosome 10 at 52,128,416 bp
  • C to T, chromosome 10 at 107,582,476 bp
  • G to T, chromosome 11 at 55,142,781 bp
  • G to A, chromosome 11 at 60,510,300 bp
  • G to A, chromosome 11 at 61,215,536 bp
  • C to T, chromosome 11 at 104,298,722 bp
  • C to T, chromosome 12 at 3,591,962 bp
  • T to C, chromosome 12 at 69,603,553 bp
  • T to C, chromosome 12 at 87,287,097 bp
  • T to A, chromosome 13 at 49,901,756 bp
  • G to A, chromosome 14 at 70,586,585 bp
  • A to T, chromosome 15 at 47,847,252 bp
  • T to A, chromosome 15 at 76,713,118 bp
  • C to T, chromosome 16 at 31,896,525 bp
  • T to A, chromosome 16 at 48,818,645 bp
  • A to G, chromosome 17 at 14,691,351 bp
  • T to A, chromosome 17 at 24,499,565 bp
  • A to G, chromosome 17 at 32,316,455 bp
  • T to A, chromosome 17 at 37,299,870 bp
  • T to C, chromosome 17 at 57,103,435 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3423 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040641-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.