Strain Name:
C57BL/6J-MtgxR3426Btlr/Mmmh
Stock Number:
040644-MU
Citation ID:
RRID:MMRRC_040644-MU
Other Names:
R3426 (G1), C57BL/6J-MtgxR3426Btlr
Major Collection:

Gene Information

Gulo
Name: gulonolactone (L-) oxidase
Synonyms: L-gulono-gamma-lactone oxidase, sfx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268756
VEGA: 14
HGNC: HGNC:4695
Homologene: 6566
Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231214
Homologene: 18159
Prelid1
Name: PRELI domain containing 1
Synonyms: 2610524G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66494
VEGA: 13
Homologene: 40859
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Adam27, Dtgn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
Prdm4
Name: PR domain containing 4
Synonyms: 2810470D21Rik, SC-1, 1700031E19Rik, SC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72843
VEGA: 10
HGNC: HGNC:9348
Homologene: 8235
Mpp7
Name: membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Synonyms: 5430426E14Rik, 2810038M04Rik, LOC381166, 1110068J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75739
VEGA: 18
Homologene: 1455
Wtap
Name: WT1 associating protein
Synonyms: 9430038B09Rik, 2810408K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 60532
Homologene: 68422
Tinagl1
Name: tubulointerstitial nephritis antigen-like 1
Synonyms: 1110021J17Rik, androgen-regulated gene 1, Arg1, Lcn7, AZ-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 94242
Homologene: 41472
Ttyh1
Name: tweety family member 1
Synonyms: tty, 6330408P11Rik, 4930459B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57776
Homologene: 10779
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Tns2
Name: tensin 2
Synonyms: nep, nph, Tenc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Plek
Name: pleckstrin
Synonyms: 2010300B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56193
HGNC: HGNC:9070
Homologene: 2000
Olfr1186
Name: olfactory receptor 1186
Synonyms: GA_x6K02T2Q125-50012960-50013871, MOR230-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258523
Homologene: 110555
Slc22a5
Name: solute carrier family 22 (organic cation transporter), member 5
Synonyms: Octn2, Lstpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20520
Homologene: 68295
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 435975
Homologene: 104832
Serac1
Name: serine active site containing 1
Synonyms: 4930511N22Rik, D17Ertd141e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 321007
Homologene: 41900
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68915
Homologene: 57502
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: 1110036I10Rik, VRL3, Nh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246788
Homologene: 17040
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Igtp
Name: interferon gamma induced GTPase
Synonyms: Irgm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16145
Homologene: 23118
Adrb3
Name: adrenergic receptor, beta 3
Synonyms: beta 3-AR, Beta-3 adrenoceptor, Beta-3 AR, beta3-adrenergic receptor, Adrb-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11556
HGNC: HGNC:288
Homologene: 37250
Utp14b
Name: UTP14B small subunit processome component
Synonyms: jsd, 4932411L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 195434
Homologene: 78703
Tmem181a
Name: transmembrane protein 181A
Synonyms: 5930418K15Rik, Gpr178, C76977, Tmem181
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77106
Homologene: 44787
Zfp606
Name: zinc finger protein 606
Synonyms: 2410022M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67370
Homologene: 23514
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68888
Homologene: 87422
Gm10044
Name: predicted gene 10044
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218695
Homologene: 141165
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 66,639,305 bp
  • T to C, chromosome 1 at 78,665,339 bp
  • GTGGCT to GT, chromosome 2 at 29,154,061 bp
  • G to A, chromosome 2 at 32,033,403 bp
  • T to A, chromosome 2 at 88,525,864 bp
  • A to T, chromosome 2 at 121,030,039 bp
  • A to G, chromosome 2 at 131,020,956 bp
  • G to T, chromosome 2 at 160,990,255 bp
  • C to A, chromosome 4 at 121,050,407 bp
  • T to C, chromosome 4 at 130,173,880 bp
  • T to C, chromosome 5 at 43,736,109 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • T to C, chromosome 7 at 4,133,219 bp
  • T to C, chromosome 7 at 12,489,664 bp
  • A to G, chromosome 7 at 42,926,982 bp
  • C to A, chromosome 8 at 24,667,604 bp
  • T to C, chromosome 8 at 27,228,181 bp
  • T to C, chromosome 10 at 85,910,289 bp
  • T to C, chromosome 11 at 16,990,142 bp
  • A to G, chromosome 11 at 53,869,326 bp
  • G to A, chromosome 11 at 58,206,593 bp
  • A to T, chromosome 11 at 73,285,941 bp
  • A to T, chromosome 12 at 52,888,034 bp
  • T to G, chromosome 13 at 55,322,194 bp
  • G to T, chromosome 14 at 7,766,211 bp
  • C to A, chromosome 14 at 66,002,577 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • T to C, chromosome 17 at 6,066,778 bp
  • T to A, chromosome 17 at 6,295,786 bp
  • C to T, chromosome 17 at 12,967,538 bp
  • A to T, chromosome 17 at 35,661,974 bp
  • T to C, chromosome 17 at 46,968,439 bp
  • A to T, chromosome 18 at 7,461,726 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3426 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040644-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.