Strain Name:
C57BL/6J-MtgxR3437Btlr/Mmmh
Stock Number:
040655-MU
Citation ID:
RRID:MMRRC_040655-MU
Other Names:
R3437 (G1), C57BL/6J-MtgxR3437Btlr
Major Collection:

Gene Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: c-KIT, Steel Factor Receptor, SCO1, Gsfsco1, belly-spot, CD117, Gsfsco5, Tr-kit, SOW3, SCO5, Dominant white spotting, Gsfsow3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Mc3r
Name: melanocortin 3 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17201
HGNC: HGNC:6931
Homologene: 7412
Dst
Name: dystonin
Synonyms: BPAG1-n, nmf203, nmf339, BPAG1, bullous pemphigoid antigen 1, A830042E19Rik, ah, Bpag, Macf2, 2310001O04Rik, Bpag1, bullous pemphigoid antigen 1, athetoid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, A930013E17Rik, Zap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56531
Homologene: 87707
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: Cyp11b-2, Cyp11b, steroid-11-beta-hydroxylase, aldosterone synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13072
Homologene: 128035
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, Pam, C130061D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: WBSCR11, BEN, Tg(Alb1-Myc)166.8Sst, ESTM9, Alb-c-myc line 166.8, Alb/c-myc line 166.8, c-myc line 166.8, binding factor for early enhancer, MusTRD1, GTF3, Cream1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Slc8a2
Name: solute carrier family 8 (sodium/calcium exchanger), member 2
Synonyms: Ncx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 110891
Homologene: 27358
Alkbh4
Name: alkB homolog 4, lysine demethylase
Synonyms: Abj4, 2010004B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72041
Homologene: 9747
Med13
Name: mediator complex subunit 13
Synonyms: Thrap1, Trap240, 1110067M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327987
Homologene: 21067
Uty
Name: ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Synonyms: Hydb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22290
Slfn2
Name: schlafen 2
Synonyms: Shlf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20556
Homologene: 133205
Angptl3
Name: angiopoietin-like 3
Synonyms: hypl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30924
HGNC: HGNC:491
Homologene: 8499
Zfy1
Name: zinc finger protein 1, Y-linked
Synonyms: Zfy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22767
Homologene: 56456
Atp6v1g1
Name: ATPase, H+ transporting, lysosomal V1 subunit G1
Synonyms: lysosomal 13kDa, VAG1, 1810024D14Rik, ATP6J, Vma10, Atp6g1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66290
HGNC: HGNC:864
Homologene: 31272
Pwwp2a
Name: PWWP domain containing 2A
Synonyms: 4631424J17Rik, D930040F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70802
Homologene: 19687
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Amy1
Name: amylase 1, salivary
Synonyms: Amy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11722
Homologene: 20179
Fabp1
Name: fatty acid binding protein 1, liver
Synonyms: L-FABP, Fabpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14080
HGNC: HGNC:3555
Homologene: 1106
Wnt16
Name: wingless-type MMTV integration site family, member 16
Synonyms: E130309I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93735
Homologene: 62175
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Avl9
Name: AVL9 cell migration associated
Synonyms: 5830411G16Rik, D730049P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78937
Homologene: 62425
Plpp2
Name: phospholipid phosphatase 2
Synonyms: Lpp2, Ppap2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50784
HGNC: HGNC:9230
Homologene: 2752
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Birc1b, Naip-rs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Pter
Name: phosphotriesterase related
Synonyms: Mpr56-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19212
HGNC: HGNC:9590
Homologene: 7495
Uspl1
Name: ubiquitin specific peptidase like 1
Synonyms: E430026A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231915
Homologene: 4235
Tro
Name: trophinin
Synonyms: trophinin-2, magphinin-gamma, magphinin-beta 2, Maged3l, Tnn, necdin and trophinin like, magphinin, Trol, magphinin-alpha, Maged3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 56191
Homologene: 75113
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 270893
Homologene: 41524
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74735
Homologene: 13241
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: Heatr7a, D330001F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223658
Homologene: 44882
Wdr66
Name: WD repeat domain 66
Synonyms: 4933428F06Rik, 4930415N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269701
Homologene: 16964
Plch2
Name: phospholipase C, eta 2
Synonyms: A930027K05Rik, Plcl4, PLCeta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384220
Homologene: 104825
Olfr136
Name: olfactory receptor 136
Synonyms: MOR256-7, GA_x6K02T2PSCP-2779375-2780313
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258803
Homologene: 119758
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: Fam5b, 6430517E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240843
Homologene: 10905
Il24
Name: interleukin 24
Synonyms: Mda-7, FISP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 93672
Homologene: 4991
Olfr312
Name: olfactory receptor 312
Synonyms: GA_x6K02T2NKPP-575829-574903, MOR222-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258065
Homologene: 77375
Gmnc
Name: geminin coiled-coil domain containing
Synonyms: LOC239789, Gm606, LOC385639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239789
VEGA: 16
Homologene: 79940
Vmn1r120
Name: vomeronasal 1 receptor 120
Synonyms: Gm5730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 435953
Homologene: 104166
Optc
Name: opticin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: MrgA3, G protein-coupled receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233222
Homologene: 131159
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320452
Homologene: 27943
Ambp
Name: alpha 1 microglobulin/bikunin precursor
Synonyms: ASPI, Itil, UTI, ulinastatin, Intin4, Urinary Trypsin Inhibitor, HI-30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11699
HGNC: HGNC:453
Homologene: 1234
Bad
Name: BCL2-associated agonist of cell death
Synonyms: Bbc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12015
HGNC: HGNC:936
Homologene: 3189
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,190,222 bp
  • A to G, chromosome 1 at 130,887,238 bp
  • T to C, chromosome 1 at 133,897,879 bp
  • A to G, chromosome 1 at 158,266,682 bp
  • T to A, chromosome 2 at 13,000,994 bp
  • C to T, chromosome 2 at 172,249,668 bp
  • G to A, chromosome 3 at 113,556,009 bp
  • C to T, chromosome 4 at 46,523,739 bp
  • T to C, chromosome 4 at 63,149,484 bp
  • A to G, chromosome 4 at 63,550,018 bp
  • A to T, chromosome 4 at 99,033,303 bp
  • A to G, chromosome 4 at 154,991,013 bp
  • A to G, chromosome 5 at 75,645,905 bp
  • A to T, chromosome 5 at 109,330,496 bp
  • A to G, chromosome 5 at 123,254,372 bp
  • A to G, chromosome 5 at 134,402,205 bp
  • T to C, chromosome 5 at 136,136,408 bp
  • T to A, chromosome 5 at 149,214,697 bp
  • T to C, chromosome 6 at 22,298,134 bp
  • T to C, chromosome 6 at 56,736,627 bp
  • T to C, chromosome 6 at 71,201,611 bp
  • T to G, chromosome 6 at 121,639,294 bp
  • T to C, chromosome 7 at 15,989,298 bp
  • T to G, chromosome 7 at 16,158,885 bp
  • A to C, chromosome 7 at 21,053,657 bp
  • A to C, chromosome 7 at 47,589,566 bp
  • C to T, chromosome 7 at 100,285,624 bp
  • C to T, chromosome 10 at 27,001,235 bp
  • A to T, chromosome 10 at 79,527,813 bp
  • T to A, chromosome 10 at 83,570,002 bp
  • C to T, chromosome 11 at 43,706,188 bp
  • A to T, chromosome 11 at 58,831,324 bp
  • A to G, chromosome 11 at 82,444,330 bp
  • A to T, chromosome 11 at 83,069,564 bp
  • A to G, chromosome 11 at 86,328,622 bp
  • T to C, chromosome 12 at 85,049,870 bp
  • T to A, chromosome 13 at 100,154,911 bp
  • T to C, chromosome 14 at 7,942,057 bp
  • T to C, chromosome 14 at 103,306,181 bp
  • T to C, chromosome 15 at 74,855,449 bp
  • C to T, chromosome 15 at 76,433,608 bp
  • G to T, chromosome 16 at 26,960,467 bp
  • A to T, chromosome 16 at 37,062,337 bp
  • A to G, chromosome 17 at 38,335,432 bp
  • A to G, chromosome 19 at 6,942,431 bp
  • G to A, chromosome X at 150,646,256 bp
  • A to T, chromosome Y at 726,357 bp
  • A to G, chromosome Y at 1,158,336 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3437 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040655-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.