Strain Name:
C57BL/6J-MtgxR3605Btlr/Mmmh
Stock Number:
040670-MU
Citation ID:
RRID:MMRRC_040670-MU
Other Names:
R3605 (G1), C57BL/6J-MtgxR3605Btlr
Major Collection:

Gene Information

Gabra6
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
Synonyms: Gabra-6, alpha6, GABA-ARalpha6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14399
HGNC: HGNC:4080
Homologene: 20220
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: Acra4, alpha4-nAChR, Acra-4, a4 nicotinic receptor, alpha4 nAChR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Thbs4
Name: thrombospondin 4
Synonyms: TSP4, TSP-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 21828
Homologene: 20691
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Arid4b
Name: AT rich interactive domain 4B (RBP1-like)
Synonyms: SAP180, RBBP1L1, Rbp1l1, 6720480E17Rik, 6330417L24Rik, BRCAA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 94246
Homologene: 12847
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233765
Homologene: 52172
Esrrg
Name: estrogen-related receptor gamma
Synonyms: Errg, ERR3, NR3B3, estrogen-related receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26381
HGNC: HGNC:3474
Homologene: 55581
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100763
Homologene: 8783
Mtdh
Name: metadherin
Synonyms: AEG-1, 3D3/Lyric, Lyric, 2610103J23Rik, D8Bwg1112e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67154
Homologene: 12089
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: Mll1, Cxxc7, trithorax Drosophila, All1, HTRX1, Mll, ALL-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Cast
Name: calpastatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12380
VEGA: 13
HGNC: HGNC:1515
Homologene: 7658
Traf2
Name: TNF receptor-associated factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22030
Homologene: 22520
Gal
Name: galanin and GMAP prepropeptide
Synonyms: Galn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14419
VEGA: 19
HGNC: HGNC:4114
Homologene: 7724
Tk2
Name: thymidine kinase 2, mitochondrial
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57813
Homologene: 3392
Zfp738
Name: zinc finger protein 738
Synonyms: 6720487G11Rik, 3830402I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408068
Homologene: 133713
Cd200r1
Name: CD200 receptor 1
Synonyms: Mox2r, CD200R, OX2R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57781
Homologene: 10957
Fgfrl1
Name: fibroblast growth factor receptor-like 1
Synonyms: FGFR5, FGFR5beta, FGFR5gamma, fibroblast growth factor receptor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 116701
HGNC: HGNC:3693
Homologene: 11067
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: C430047I10Rik, 5530600M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Lctl
Name: lactase-like
Synonyms: E130104I05Rik, KLPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235435
Homologene: 70710
Grik4
Name: glutamate receptor, ionotropic, kainate 4
Synonyms: GluRgamma1, KA-1, 6330551K01Rik, KA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110637
HGNC: HGNC:4582
Homologene: 81829
Rbl1
Name: RB transcriptional corepressor like 1
Synonyms: retinoblastoma-like 1 (p107), p107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19650
HGNC: HGNC:9893
Homologene: 2172
Mnt
Name: max binding protein
Synonyms: bHLHd3, Rox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17428
HGNC: HGNC:7188
Homologene: 7842
Ranbp10
Name: RAN binding protein 10
Synonyms: 4432417N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74334
Homologene: 49639
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Bpifb1
Name: BPI fold containing family B, member 1
Synonyms: von Ebner minor salivary protein, U46068, LPlunc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228801
Homologene: 50047
Ttn
Name: titin
Synonyms: shru, L56, mdm, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, D330041I19Rik, D830007G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Crb1
Name: crumbs family member 1, photoreceptor morphogenesis associated
Synonyms: A930008G09Rik, 7530426H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 170788
HGNC: HGNC:2343
Homologene: 8092
Yif1b
Name: Yip1 interacting factor homolog B (S. cerevisiae)
Synonyms: 9430029K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77254
Homologene: 60114
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: Polydom, 4833413O10Rik, 1110021D17Rik, D430029O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213121
Homologene: 16977
Cracr2b
Name: calcium release activated channel regulator 2B
Synonyms: 6330520A15Rik, Efcab4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 213573
Homologene: 45468
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Kprp
Name: keratinocyte expressed, proline-rich
Synonyms: 1110001M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433619
Homologene: 54921
Olfr195
Name: olfactory receptor 195
Synonyms: GA_x54KRFPKG5P-55369823-55370749, MOR184-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 259000
Homologene: 128109
Rpap2
Name: RNA polymerase II associated protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231571
Homologene: 11733
Nxt1
Name: NTF2-related export protein 1
Synonyms: 1110001N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56488
Homologene: 8301
Hcn1
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Synonyms: Bcng1, C630013B14Rik, HAC2, hyperpolarization-activated, cyclic nucleotide-gated K+ 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15165
HGNC: HGNC:4845
Homologene: 32093
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: 1110020H15Rik, TBR-II, TbetaR-II, TbetaRII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Olfr1312
Name: olfactory receptor 1312
Synonyms: MOR245-20, GA_x6K02T2Q125-73090482-73089529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258359
Homologene: 128122
D830014E11Rik
Name: RIKEN cDNA D830014E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320751
VEGA: 5
Art2b
Name: ADP-ribosyltransferase 2b
Synonyms: ART2.2, Rt-6, Rt6-2, Rt6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11872
Homologene: 113756
AC112683.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Sapcd1
Name: suppressor APC domain containing 1
Synonyms: G7d, Ng23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78376
Homologene: 86703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 14,270,853 bp
  • T to A, chromosome 1 at 139,237,339 bp
  • A to G, chromosome 1 at 188,211,102 bp
  • T to C, chromosome 2 at 25,530,415 bp
  • C to T, chromosome 2 at 76,831,444 bp
  • T to C, chromosome 2 at 82,984,909 bp
  • G to C, chromosome 2 at 98,664,007 bp
  • T to A, chromosome 2 at 112,042,823 bp
  • T to A, chromosome 2 at 140,661,367 bp
  • T to C, chromosome 2 at 148,675,479 bp
  • T to A, chromosome 2 at 154,211,565 bp
  • A to T, chromosome 2 at 157,177,233 bp
  • T to C, chromosome 2 at 181,034,166 bp
  • C to A, chromosome 3 at 92,824,281 bp
  • C to T, chromosome 3 at 96,682,181 bp
  • A to T, chromosome 4 at 58,066,542 bp
  • A to G, chromosome 5 at 29,598,938 bp
  • G to A, chromosome 5 at 105,827,007 bp
  • A to G, chromosome 5 at 107,620,529 bp
  • C to A, chromosome 5 at 108,705,423 bp
  • C to T, chromosome 7 at 29,238,410 bp
  • T to C, chromosome 7 at 80,723,789 bp
  • T to A, chromosome 7 at 101,579,945 bp
  • T to C, chromosome 7 at 116,164,242 bp
  • C to T, chromosome 7 at 141,466,146 bp
  • A to G, chromosome 8 at 104,231,171 bp
  • A to G, chromosome 8 at 105,776,035 bp
  • A to G, chromosome 9 at 42,542,056 bp
  • G to A, chromosome 9 at 44,849,196 bp
  • T to C, chromosome 9 at 64,133,193 bp
  • G to A, chromosome 9 at 116,109,892 bp
  • T to A, chromosome 11 at 42,314,950 bp
  • T to A, chromosome 11 at 74,836,920 bp
  • T to C, chromosome 13 at 14,120,241 bp
  • A to T, chromosome 13 at 67,671,389 bp
  • A to G, chromosome 13 at 74,746,117 bp
  • G to T, chromosome 13 at 92,757,959 bp
  • G to A, chromosome 13 at 117,975,252 bp
  • T to A, chromosome 15 at 34,114,112 bp
  • A to G, chromosome 16 at 44,789,576 bp
  • T to C, chromosome 16 at 59,149,483 bp
  • A to G, chromosome 17 at 35,027,805 bp
  • G to T, chromosome 17 at 47,410,505 bp
  • T to A, chromosome 18 at 34,473,696 bp
  • A to G, chromosome 19 at 3,414,026 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3605 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040670-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.