Strain Name:
C57BL/6J-MtgxR3622Btlr/Mmmh
Stock Number:
040677-MU
Citation ID:
RRID:MMRRC_040677-MU
Other Names:
R3622 (G1), C57BL/6J-MtgxR3622Btlr
Major Collection:

Gene Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 104245
Homologene: 37901
Htr1d
Name: 5-hydroxytryptamine (serotonin) receptor 1D
Synonyms: Gpcr14, Htr1db
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15552
HGNC: HGNC:5289
Homologene: 20240
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 29808
Homologene: 49351
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Vps53
Name: VPS53 GARP complex subunit
Synonyms: 2310040I21Rik, 2010002A08Rik, 3100002B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68299
Homologene: 6264
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Elp1
Name: elongator complex protein 1
Synonyms: 3110040G09Rik, C78473, IKAP, Ikbkap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Snrpb
Name: small nuclear ribonucleoprotein B
Synonyms: SNRNP-B, SM11, SMB, SM-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20638
Homologene: 134543
Phka2
Name: phosphorylase kinase alpha 2
Synonyms: k, Phk, 6330505C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 110094
HGNC: HGNC:8926
Homologene: 246
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170935
Homologene: 15781
Oma1
Name: OMA1 zinc metallopeptidase
Synonyms: 2010001O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67013
Homologene: 12070
Midn
Name: midnolin
Synonyms: 3000003C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 59090
Homologene: 32510
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
Hyal4
Name: hyaluronoglucosaminidase 4
Synonyms: 4632428M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77042
HGNC: HGNC:5323
Homologene: 69117
Olfr994
Name: olfactory receptor 994
Synonyms: GA_x6K02T2Q125-46907515-46906571, MOR203-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258425
Homologene: 17245
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: EG619697, V2Rp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619697
Homologene: 86604
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320631
Homologene: 87255
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: PRO0813, TAT1, 2610103N14Rik, Mct10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Olfr1461
Name: olfactory receptor 1461
Synonyms: GA_x6K02T2RE5P-3491834-3492772, MOR202-35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258299
Homologene: 128112
Scml4
Name: Scm polycomb group protein like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268297
Homologene: 18262
Gucy2e
Name: guanylate cyclase 2e
Synonyms: ROS-GC1, GC-E, GC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14919
HGNC: HGNC:4689
Homologene: 55442
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Olfr390
Name: olfactory receptor 390
Synonyms: GA_x6K02T2P1NL-3938806-3939741, MOR135-26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258344
Homologene: 115483
Pbld1
Name: phenazine biosynthesis-like protein domain containing 1
Synonyms: 0610038K03Rik, Pbld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68371
VEGA: 10
Homologene: 41470
Srsf9
Name: serine and arginine-rich splicing factor 9
Synonyms: SRp30c, 2610029M16Rik, Sfrs9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108014
Homologene: 20819
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Tgm6
Name: transglutaminase 6
Synonyms: TGM3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241636
Homologene: 27970
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57435
Homologene: 69311
Dffb
Name: DNA fragmentation factor, beta subunit
Synonyms: Didff, 40kDa, 5730477D02Rik, DFF40, CPAN, caspase-activated DNase, CAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13368
HGNC: HGNC:2773
Homologene: 3241
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: Veph, 2810471M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72789
Homologene: 11624
Tyk2
Name: tyrosine kinase 2
Synonyms: JTK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54721
VEGA: 9
Homologene: 20712
Vmn1r30
Name: vomeronasal 1 receptor 30
Synonyms: V1rc9, V1rc22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171195
Homologene: 137652
R3hdm4
Name: R3H domain containing 4
Synonyms: C030046I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 109284
VEGA: 10
Homologene: 16343
Upp2
Name: uridine phosphorylase 2
Synonyms: UDRPASE2, UPASE2, UP2, 1700124F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76654
Homologene: 12654
Olfr912
Name: olfactory receptor 912
Synonyms: GA_x6K02T2PVTD-32283590-32284522, MOR165-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258806
VEGA: 9
Homologene: 115510
Stfa2
Name: stefin A2
Synonyms: Stf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20862
VEGA: 16
HGNC: HGNC:2481
Homologene: 86269
Rps18
Name: ribosomal protein S18
Synonyms: H2-Ke3, H-2Ke3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20084
Homologene: 88764
Smad9
Name: SMAD family member 9
Synonyms: Madh9, SMAD8B, SMAD8A, MADH6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
Dpf1
Name: D4, zinc and double PHD fingers family 1
Synonyms: neuro-d4, Neud4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29861
Homologene: 3415
AC171501.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 2 at 58,790,116 bp
  • C to T, chromosome 2 at 85,430,493 bp
  • A to G, chromosome 2 at 119,941,764 bp
  • T to A, chromosome 2 at 130,151,761 bp
  • C to A, chromosome 2 at 130,175,379 bp
  • C to T, chromosome 3 at 54,789,284 bp
  • C to T, chromosome 3 at 66,215,437 bp
  • C to T, chromosome 3 at 96,651,738 bp
  • A to T, chromosome 4 at 56,759,925 bp
  • T to C, chromosome 4 at 103,366,091 bp
  • T to C, chromosome 4 at 136,443,504 bp
  • T to C, chromosome 4 at 153,965,519 bp
  • C to A, chromosome 5 at 3,976,235 bp
  • C to T, chromosome 5 at 115,330,512 bp
  • T to C, chromosome 5 at 143,386,019 bp
  • A to T, chromosome 6 at 3,374,032 bp
  • A to T, chromosome 6 at 17,549,086 bp
  • A to T, chromosome 6 at 24,765,738 bp
  • A to T, chromosome 6 at 58,435,452 bp
  • A to T, chromosome 6 at 67,724,960 bp
  • G to A, chromosome 7 at 29,316,206 bp
  • T to C, chromosome 7 at 49,917,623 bp
  • T to A, chromosome 7 at 120,350,813 bp
  • T to C, chromosome 7 at 141,851,858 bp
  • A to T, chromosome 9 at 21,127,310 bp
  • A to G, chromosome 9 at 38,581,496 bp
  • A to G, chromosome 10 at 40,141,894 bp
  • T to C, chromosome 10 at 42,930,611 bp
  • T to C, chromosome 10 at 63,061,691 bp
  • C to T, chromosome 10 at 79,912,681 bp
  • A to G, chromosome 10 at 80,150,310 bp
  • A to G, chromosome 10 at 88,757,993 bp
  • T to A, chromosome 11 at 69,225,051 bp
  • A to G, chromosome 11 at 73,787,741 bp
  • A to C, chromosome 11 at 76,117,783 bp
  • C to T, chromosome 11 at 117,749,625 bp
  • A to G, chromosome 16 at 36,404,071 bp
  • A to G, chromosome 17 at 23,386,051 bp
  • G to C, chromosome 17 at 33,952,273 bp
  • G to T, chromosome 17 at 56,104,112 bp
  • A to G, chromosome 17 at 67,884,820 bp
  • T to A, chromosome 19 at 13,165,656 bp
  • T to A, chromosome X at 160,544,295 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3622 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040677-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.