Strain Name:
C57BL/6J-MtgxR3683Btlr/Mmmh
Stock Number:
040681-MU
Citation ID:
RRID:MMRRC_040681-MU
Other Names:
R3683 (G1), C57BL/6J-MtgxR3683Btlr
Major Collection:

Strain Information

Zmpste24
Name: zinc metallopeptidase, STE24
Synonyms: A530043O15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230709
Homologene: 4277
Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Calb2
Name: calbindin 2
Synonyms: calretinin, CR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12308
HGNC: HGNC:1435
Homologene: 1318
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Zfand6
Name: zinc finger, AN1-type domain 6
Synonyms: Awp1, 3110005P07Rik, Za20d3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 65098
Homologene: 10372
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: RBBP1L1, SAP180, BRCAA1, Rbp1l1, 6720480E17Rik, 6330417L24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230793
Homologene: 17144
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: GALT, alpha Gal, Gal, glycoprotein alpha galactosyl transferase 1, alpha3GalT, Ggta-1, Ggta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: Sumo-1 activating enzyme subunit 2, UBA2, anthracycline-associated resistance, Arx, SAE2, Uble1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50995
Homologene: 4018
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: 5730409A01Rik, 1810061H24Rik, SAP130, RSE1, D8Ertd633e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 101943
Homologene: 6579
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Clcn7
Name: chloride channel, voltage-sensitive 7
Synonyms: ClC-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26373
HGNC: HGNC:2025
Homologene: 56546
Ntm
Name: neurotrimin
Synonyms: 6230410L23Rik, B230210G24Rik, Hnt
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235106
Homologene: 41139
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Bmp2
Name: bone morphogenetic protein 2
Synonyms: Bmp2a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12156
HGNC: HGNC:1069
Homologene: 926
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Mgme1
Name: mitochondrial genome maintenance exonuclease 1
Synonyms: 8430406I07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74528
Homologene: 12573
Phf21b
Name: PHD finger protein 21B
Synonyms: A730032D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271305
Homologene: 78154
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Tbc1d20
Name: TBC1 domain family, member 20
Synonyms: 1110028I04Rik, 2810442O16Rik, bs
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67231
Homologene: 32574
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20849
Homologene: 20679
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20663
Homologene: 38253
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Or4c118
Name: olfactory receptor family 4 subfamily C member 118
Synonyms: GA_x6K02T2Q125-50623664-50622729, MOR233-10, Olfr1223
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258894
Homologene: 79379
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53419
Homologene: 4804
Acad11
Name: acyl-Coenzyme A dehydrogenase family, member 11
Synonyms: 5730439E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102632
Homologene: 49896
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231589
Homologene: 129606
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), neurexin I beta, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I alpha, 1700062G21Rik, A230068P09Rik, 9330127H16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Elp4
Name: elongator acetyltransferase complex subunit 4
Synonyms: A330107A17Rik, Paxneb
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77766
HGNC: HGNC:1171
Homologene: 32433
Fbxw24
Name: F-box and WD-40 domain protein 24
Synonyms: Gm5162
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382106
Homologene: 110776
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Or5d37
Name: olfactory receptor family 5 subfamily D member 37
Synonyms: GA_x6K02T2Q125-49585842-49584862, MOR174-11, Olfr1164
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258634
Homologene: 74077
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: LOC210544, D330013L20Rik, Wdr67
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210544
Homologene: 17089
Serpinb9b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9b
Synonyms: 1600019A21Rik, ovalbumin, Spi10, R86, SPI-CI
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20706
HGNC: HGNC:8955
Homologene: 137240
Cables2
Name: CDK5 and Abl enzyme substrate 2
Synonyms: ik3-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 252966
Homologene: 45440
Or4a73
Name: olfactory receptor family 4 subfamily A member 73
Synonyms: GA_x6K02T2Q125-51034790-51033846, MOR231-9, Olfr1246
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258788
Homologene: 74246
Tmcc1
Name: transmembrane and coiled coil domains 1
Synonyms: 3632431M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330401
Homologene: 8995
Myg1
Name: melanocyte proliferating gene 1
Synonyms: Gamm1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 60315
Homologene: 5853
Acat1
Name: acetyl-Coenzyme A acetyltransferase 1
Synonyms: Acat, 6330585C21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110446
HGNC: HGNC:93
Homologene: 6
Vmn1r8
Name: vomeronasal 1 receptor 8
Synonyms: V1rc32
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171205
Homologene: 83427
Csrnp2
Name: cysteine-serine-rich nuclear protein 2
Synonyms: CSRNP-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207785
VEGA: 15
Homologene: 32743
Smpd1
Name: sphingomyelin phosphodiesterase 1, acid lysosomal
Synonyms: A-SMase, aSMase, ASM, acid sphingomyelinase, Zn-SMase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20597
Homologene: 457
Srsf8
Name: serine and arginine rich splicing factor 8
Synonyms: 4930595M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245492
Homologene: 138416
Tmem181a
Name: transmembrane protein 181A
Synonyms: 5930418K15Rik, Gpr178, C76977, Tmem181
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77106
Homologene: 44787
Or2d3c
Name: olfactory receptor family 2 subfamily D member 3C
Synonyms: GA_x6K02T2PBJ9-9307730-9306814, MOR260-7, Olfr709
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258146
Gldn
Name: gliomedin
Synonyms: Crlg2, CRG-L2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235379
Homologene: 14529
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 52,013,822 bp
  • C to A, chromosome 1 at 53,444,516 bp
  • T to C, chromosome 1 at 128,304,226 bp
  • T to A, chromosome 2 at 35,407,988 bp
  • A to G, chromosome 2 at 41,960,788 bp
  • T to A, chromosome 2 at 88,093,259 bp
  • A to T, chromosome 2 at 89,145,020 bp
  • C to A, chromosome 2 at 89,590,755 bp
  • A to T, chromosome 2 at 105,702,761 bp
  • G to T, chromosome 2 at 124,654,226 bp
  • T to A, chromosome 2 at 133,554,472 bp
  • T to C, chromosome 2 at 144,276,545 bp
  • A to G, chromosome 2 at 150,268,056 bp
  • C to T, chromosome 2 at 152,311,817 bp
  • G to A, chromosome 2 at 180,264,470 bp
  • A to G, chromosome 4 at 121,061,091 bp
  • T to C, chromosome 4 at 133,065,702 bp
  • T to C, chromosome 5 at 72,330,855 bp
  • C to A, chromosome 5 at 109,156,855 bp
  • A to C, chromosome 6 at 57,036,275 bp
  • C to CAT, chromosome 6 at 116,042,870 bp
  • A to G, chromosome 7 at 34,158,810 bp
  • G to A, chromosome 7 at 84,634,362 bp
  • T to A, chromosome 7 at 105,555,402 bp
  • G to A, chromosome 7 at 106,927,094 bp
  • A to G, chromosome 7 at 130,625,070 bp
  • A to G, chromosome 8 at 45,017,938 bp
  • A to G, chromosome 8 at 110,156,988 bp
  • A to G, chromosome 8 at 110,813,621 bp
  • T to C, chromosome 9 at 29,109,393 bp
  • A to G, chromosome 9 at 35,489,032 bp
  • C to T, chromosome 9 at 53,587,465 bp
  • G to A, chromosome 9 at 54,338,340 bp
  • T to C, chromosome 9 at 104,115,344 bp
  • G to A, chromosome 9 at 109,608,042 bp
  • T to C, chromosome 9 at 118,553,597 bp
  • A to G, chromosome 10 at 12,666,835 bp
  • G to T, chromosome 10 at 107,708,628 bp
  • T to A, chromosome 12 at 69,657,946 bp
  • T to A, chromosome 12 at 103,074,803 bp
  • T to A, chromosome 13 at 14,164,102 bp
  • C to T, chromosome 13 at 33,029,598 bp
  • A to C, chromosome 15 at 6,837,053 bp
  • T to C, chromosome 15 at 57,951,814 bp
  • A to G, chromosome 15 at 84,798,690 bp
  • A to T, chromosome 15 at 100,481,998 bp
  • G to C, chromosome 15 at 102,337,736 bp
  • T to A, chromosome 17 at 6,295,786 bp
  • T to C, chromosome 17 at 25,150,593 bp
  • A to G, chromosome 17 at 67,768,333 bp
  • T to C, chromosome 17 at 90,623,452 bp
  • T to C, chromosome X at 81,420,235 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3683 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040681-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.