Strain Name:
C57BL/6J-MtgxR3691Btlr/Mmmh
Stock Number:
040686-MU
Citation ID:
RRID:MMRRC_040686-MU
Other Names:
R3691 (G1), C57BL/6J-MtgxR3691Btlr
Major Collection:

Strain Information

Itprip
Name: inositol 1,4,5-triphosphate receptor interacting protein
Synonyms: DANGER
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 414801
VEGA: 19
Homologene: 62157
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Srsf16, Sfrs16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53609
Homologene: 134306
Thoc7
Name: THO complex 7
Synonyms: 1500006O09Rik, 9230101K24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66231
VEGA: 14
Homologene: 11821
Gk5
Name: glycerol kinase 5
Synonyms: C330018K18Rik, G630067D24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235533
Homologene: 15141
Med13l
Name: mediator complex subunit 13-like
Synonyms: 6330591G05Rik, 9030618F05Rik, Thrap2, Trap240L, 2210413I17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Drosha
Name: drosha, ribonuclease type III
Synonyms: Rnasen, 1110013A17Rik, Etohi2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Foxj3
Name: forkhead box J3
Synonyms: Fhd6, C330039G02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230700
Homologene: 35243
Cog3
Name: component of oligomeric golgi complex 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338337
VEGA: 14
Homologene: 5854
Afdn
Name: afadin, adherens junction formation factor
Synonyms: 5033403D15Rik, Afadin, I-afadin, Mllt4, S-afadin, AF6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Cap1
Name: cyclase associated actin cytoskeleton regulatory protein 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12331
Homologene: 74572
Mxi1
Name: MAX interactor 1, dimerization protein
Synonyms: Mad2, bHLHc11
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17859
VEGA: 19
HGNC: HGNC:7534
Homologene: 4351
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: 2310038O07Rik, D10Ertd516e, 6330512O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71902
Homologene: 10202
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Napb
Name: N-ethylmaleimide sensitive fusion protein attachment protein beta
Synonyms: Brp14, SNARE, I47, b-SNAP, E161
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17957
Homologene: 5332
Nsun2
Name: NOL1/NOP2/Sun domain family member 2
Synonyms: Misu
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 28114
Homologene: 9817
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Ccdc131, Psrc2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216345
Homologene: 17017
Mideas
Name: mitotic deacetylase associated SANT domain protein
Synonyms: Elmsan1, C130039O16Rik, 9430029N19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238317
Homologene: 19330
Flywch1
Name: FLYWCH-type zinc finger 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224613
VEGA: 17
Homologene: 72130
Avl9
Name: AVL9 cell migration associated
Synonyms: D730049P16Rik, 5830411G16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78937
Homologene: 62425
Pcnx4
Name: pecanex homolog 4
Synonyms: 1810048J11Rik, Pcnxl4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67708
VEGA: 12
Homologene: 23366
Efr3b
Name: EFR3 homolog B
Synonyms: C030014M07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668212
VEGA: 12
Homologene: 66195
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Fbxo17
Name: F-box protein 17
Synonyms: FBXO26, Fbx17, Fbg4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50760
Homologene: 17523
Serpina6
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms: Cbg
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12401
HGNC: HGNC:1540
Homologene: 20417
Lmo3
Name: LIM domain only 3
Synonyms: Rbtn3, Rbtn-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109593
HGNC: HGNC:6643
Homologene: 38552
Epha1
Name: Eph receptor A1
Synonyms: Eph, Esk, 5730453L17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Gzmg
Name: granzyme G
Synonyms: Ctla7, Ctla-7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14944
VEGA: 14
Homologene: 133275
Fbln7
Name: fibulin 7
Synonyms: 1600015H20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70370
Homologene: 11489
Lrrc69
Name: leucine rich repeat containing 69
Synonyms: 1700034K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73314
Homologene: 78018
Or10ag2
Name: olfactory receptor family 10 subfamily AG member 2
Synonyms: MOR264-17, GA_x6K02T2Q125-48917235-48918206, Olfr1123
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258347
Homologene: 105187
Oxct1
Name: 3-oxoacid CoA transferase 1
Synonyms: Scot-s, 2610008O03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67041
HGNC: HGNC:8527
Homologene: 377
Best2
Name: bestrophin 2
Synonyms: Vmd2l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212989
Homologene: 41187
Gm12588
Name: predicted gene 12588
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Homologene: 137828
Btbd19
Name: BTB domain containing 19
Synonyms: 9530048O09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78611
Gm3248
Name: predicted gene 3248
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100041279
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 87,418,170 bp
  • T to C, chromosome 2 at 128,880,437 bp
  • T to C, chromosome 2 at 148,703,057 bp
  • A to T, chromosome 4 at 14,795,980 bp
  • A to T, chromosome 4 at 117,120,592 bp
  • T to C, chromosome 4 at 119,616,642 bp
  • A to G, chromosome 4 at 122,864,626 bp
  • C to T, chromosome 5 at 96,781,512 bp
  • A to G, chromosome 5 at 118,721,497 bp
  • A to G, chromosome 5 at 137,420,019 bp
  • A to G, chromosome 5 at 144,209,979 bp
  • T to C, chromosome 6 at 42,361,130 bp
  • C to T, chromosome 6 at 56,736,827 bp
  • A to G, chromosome 6 at 138,366,053 bp
  • C to A, chromosome 7 at 19,585,240 bp
  • G to A, chromosome 7 at 28,737,462 bp
  • G to A, chromosome 8 at 71,334,337 bp
  • A to G, chromosome 8 at 85,011,254 bp
  • T to C, chromosome 9 at 96,129,096 bp
  • A to G, chromosome 10 at 115,420,690 bp
  • A to T, chromosome 10 at 119,212,595 bp
  • T to C, chromosome 11 at 60,719,757 bp
  • T to G, chromosome 11 at 121,905,925 bp
  • T to A, chromosome 12 at 3,982,059 bp
  • A to G, chromosome 12 at 72,573,719 bp
  • C to T, chromosome 12 at 84,156,471 bp
  • T to C, chromosome 12 at 103,654,409 bp
  • A to G, chromosome 13 at 69,612,337 bp
  • A to T, chromosome 13 at 81,481,838 bp
  • A to G, chromosome 14 at 5,943,068 bp
  • A to T, chromosome 14 at 13,950,289 bp
  • T to A, chromosome 14 at 56,157,677 bp
  • T to C, chromosome 14 at 75,754,438 bp
  • A to G, chromosome 15 at 4,047,517 bp
  • G to A, chromosome 15 at 12,834,638 bp
  • A to G, chromosome 17 at 13,888,409 bp
  • G to A, chromosome 17 at 23,763,212 bp
  • G to A, chromosome 19 at 47,897,073 bp
  • T to C, chromosome 19 at 53,369,631 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3691 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040686-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.